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Muscle Satellite Cells and Endothelial Cells: Close Neighbors and Privileged Partners.

Abstract : Monitoring Editor: Marianne Bronner-Fraser Genetically engineered mice (Myf5(nLacZ/+), Myf5(GFP-P/+)) allowing direct muscle satellite cell (SC) visualization indicate that, in addition to being located beneath myofiber basal laminae, SCs are strikingly close to capillaries. After GFP(+) bone marrow transplantation, blood-borne cells occupying SC niches previously depleted by irradiation, were similarly detected near vessels, thereby corroborating the anatomical stability of juxtavascular SC niches. BrdU pulse-chase experiments also localize quiescent and less quiescent SCs near vessels. SCs, and to a lesser extent myonuclei, were nonrandomly associated with capillaries in humans. Significantly, they were correlated with capillarisation of myofibers, regardless to their type, in normal muscle. They also varied in paradigmatic physiological and pathological situations associated with variations of capillary density, including amyopathic dermatomyositis, a unique condition in which muscle capillary loss occurs without myofiber damage, and in athletes, in whom capillaries increase in number. Endothelial cell (EC) cultures specifically enhanced SC growth, through IGF-1, HGF, bFGF, PDGF-BB and VEGF, and, accordingly, cycling SCs remained mainly juxtavascular. Conversely, differentiating myogenic cells were both proangiogenic in vitro and spatiotemporally associated with neoangiogenesis in muscular dystrophy. Thus, SCs are largely juxtavascular and reciprocally interact with ECs during differentiation to support angio-myogenesis.
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Submitted on : Monday, February 12, 2007 - 11:17:50 AM
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Christo Christov, Fabrice Chrétien, Rana Abou Khalil, Guillaume Bassez, Grégoire Vallet, et al.. Muscle Satellite Cells and Endothelial Cells: Close Neighbors and Privileged Partners.. Molecular Biology of the Cell, American Society for Cell Biology, 2007, 18 (4), pp.1397-1409. ⟨10.1091/mbc.E06-08-0693⟩. ⟨inserm-00128985⟩



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