Skip to Main content Skip to Navigation
Journal articles

ERK2: a logical AND gate critical for drug-induced plasticity?: ERK2 and drug-induced plasticity

Abstract : Drug addiction results in part from the distortion of dopamine-controlled plasticity, and extracellular signal-regulated kinase (ERK) plays an important role in the underlying molecular mechanisms of this process. ERK is activated by drugs of abuse in a subset of neurons in reward-related brain regions. This activation, necessary for the expression of immediate early genes, depends upon dopamine D1 and glutamate receptors. Blockade of ERK activation prevents long-lasting behavioral changes, including psychomotor sensitization and conditioned place preference. It also interferes with drug craving and drug-associated memory reconsolidation. By contrast, ERK1 mutation enhances the effects of morphine and cocaine. We suggest that the ERK2 pathway acts as a logical AND gate, permissive for plasticity, in neurons on which dopamine-mediated reward signals and glutamate-mediated contextual information converge.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00128883
Contributor : Jean-Antoine Girault <>
Submitted on : Monday, February 5, 2007 - 3:14:01 PM
Last modification on : Monday, August 31, 2020 - 11:42:25 AM
Long-term archiving on: : Wednesday, April 7, 2010 - 2:38:12 AM

Identifiers

Collections

Citation

Jean-Antoine Girault, Emmanuel Valjent, Jocelyne Caboche, Denis Hervé. ERK2: a logical AND gate critical for drug-induced plasticity?: ERK2 and drug-induced plasticity. Current Opinion in Pharmacology, Elsevier, 2007, 7 (1), pp.77-85. ⟨10.1016/j.coph.2006.08.012⟩. ⟨inserm-00128883⟩

Share

Metrics

Record views

460

Files downloads

1567