A. Wobus and K. Boheler, Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy, Physiological Reviews, vol.85, issue.2, pp.635-78, 2005.
DOI : 10.1152/physrev.00054.2003

G. Keller, Embryonic stem cell differentiation: emergence of a new era in biology and medicine, Genes & Development, vol.19, issue.10, pp.1129-55, 2005.
DOI : 10.1101/gad.1303605

A. Smith, J. Heath, and D. Donaldson, Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides, Nature, vol.336, issue.6200, pp.688-90, 1988.
DOI : 10.1038/336688a0

R. Williams, D. Hilton, and S. Pease, Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells, Nature, vol.336, issue.6200, pp.684-691, 1988.
DOI : 10.1038/336684a0

A. Wobus, Potential of embryonic stem cells, Molecular Aspects of Medicine, vol.22, issue.3, pp.149-64, 2001.
DOI : 10.1016/S0098-2997(01)00006-1

I. Munoz-sanjuan and A. Brivanlou, NEURAL INDUCTION, THE DEFAULT MODEL AND EMBRYONIC STEM CELLS, Nature Reviews Neuroscience, vol.3, issue.4, pp.271-80, 2002.
DOI : 10.1038/nrn786

C. Amura, L. Marek, and R. Winn, Inhibited Neurogenesis in JNK1-Deficient Embryonic Stem Cells, Molecular and Cellular Biology, vol.25, issue.24, pp.10791-802, 2005.
DOI : 10.1128/MCB.25.24.10791-10802.2005

J. Rohwedel, K. Guan, and A. Wobus, Induction of Cellular Differentiation by Retinoic Acid in vitro, Cells Tissues Organs, vol.165, issue.3-4, pp.190-202, 1999.
DOI : 10.1159/000016699

Q. Ying, M. Stavridis, and D. Griffiths, Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture, Nature Biotechnology, vol.128, issue.2, pp.183-186, 2003.
DOI : 10.1038/nbt780

M. Aouadi, F. Bost, and L. Caron, p38 Mitogen-Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis, Stem Cells, vol.87, issue.5, pp.1399-406, 2006.
DOI : 10.1634/stemcells.2005-0398

G. Pearson, F. Robinson, B. Gibson, and T. , Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions, Endocrine Reviews, vol.22, issue.2, pp.153-83, 2001.
DOI : 10.1210/er.22.2.153

S. Torii, T. Yamamoto, and Y. Tsuchiya, ERK MAP kinase in G1 cell cycle progression and cancer, Cancer Science, vol.17, issue.8, pp.697-702, 2006.
DOI : 10.1093/carcin/bgi066

T. Zarubin and J. Han, Activation and signaling of the p38 MAP kinase pathway, Cell Research, vol.62, issue.1, pp.11-18, 2005.
DOI : 10.1038/ng894

S. Papa, C. Bubici, and F. Zazzeroni, The NF-[kappa]B-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease, pp.712-729, 2006.

J. Bain, H. Mclauchlan, and M. Elliott, The specificities of protein kinase inhibitors: an update, Biochem J, vol.371, pp.199-204, 2003.

M. Aouadi, B. Binétruy, and L. Caron, Role of??MAPKs in??development and??differentiation: lessons from knockout mice, Biochimie, vol.88, issue.9, pp.1091-1099, 2006.
DOI : 10.1016/j.biochi.2006.06.003

H. Niwa, T. Burdon, and I. Chambers, Self-renewal of pluripotent embryonic stem cells is mediated via activation of??STAT3, Genes & Development, vol.12, issue.13, pp.2048-60, 1998.
DOI : 10.1101/gad.12.13.2048

T. Burdon, I. Chambers, and C. Stracey, Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells, Cells Tissues Organs, vol.165, issue.3-4, pp.131-174, 1999.
DOI : 10.1159/000016693

T. Burdon, A. Smith, and P. Savatier, Signalling, cell cycle and pluripotency in embryonic stem cells, Trends in Cell Biology, vol.12, issue.9, pp.432-440, 2002.
DOI : 10.1016/S0962-8924(02)02352-8

T. Burdon, C. Stracey, and I. Chambers, Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation, Dev Biol. Cell, vol.210, issue.95, pp.30-43, 1998.

C. Chazaud, Y. Yamanaka, and T. Pawson, Early Lineage Segregation between Epiblast and Primitive Endoderm in Mouse Blastocysts through the Grb2-MAPK Pathway, Developmental Cell, vol.10, issue.5, pp.615-624, 2006.
DOI : 10.1016/j.devcel.2006.02.020

U. Yoshida-koide, T. Matsuda, and K. Saikawa, Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells, Biochemical and Biophysical Research Communications, vol.313, issue.3, pp.475-481, 2004.
DOI : 10.1016/j.bbrc.2003.11.138

F. Bost, L. Caron, and I. Marchetti, Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage, Biochemical Journal, vol.361, issue.3, pp.621-628, 2002.
DOI : 10.1042/bj3610621

F. Bost, M. Aouadi, and L. Caron, The role of MAPKs in adipocyte differentiation and obesity, Biochimie, vol.87, issue.1, pp.51-57, 1999.
DOI : 10.1016/j.biochi.2004.10.018

URL : https://hal.archives-ouvertes.fr/inserm-00000011

M. Saba-el-leil, F. Vella, and B. Vernay, An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development, EMBO reports, vol.79, issue.10, pp.964-972, 2003.
DOI : 10.1038/sj.embor.embor939

Y. Yao, W. Li, and J. Wu, Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation, Epub 2003 Oct 17. 34 Yang SH, Sharrocks AD and Whitmarsh AJ. Transcriptional regulation by the MAP kinase signaling cascades, pp.12759-64, 2003.
DOI : 10.1074/jbc.274.20.14434

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC240691

E. Hu, J. Kim, and P. Sarraf, Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPAR??, Science, vol.18, issue.12, pp.2100-2103, 1996.
DOI : 10.1093/nar/18.12.3587

H. Camp and S. Tafuri, Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase, J Biol Chem, vol.272, pp.10811-10817, 1997.

K. Tamura, T. Sudo, and U. Senftleben, Adipocyte Differentiation Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway, J Biol Chem Cell Developmental Biology, vol.279, issue.283, pp.39951-39958, 2000.

M. Allen, L. Svensson, and M. Roach, Deficiency of the Stress Kinase P38?? Results in Embryonic Lethality, The Journal of Experimental Medicine, vol.111, issue.5, pp.859-70, 2000.
DOI : 10.1074/jbc.274.8.5193

D. Duval, M. Malaise, and B. Reinhardt, A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells, Cell Death and Differentiation, vol.11, issue.3, pp.331-372, 2004.
DOI : 10.1038/sj.cdd.4401337

M. Aouadi, K. Laurent, and M. Prot, Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages Mitogen-activated Protein Kinases and Mitogen-activated Protein Kinase Phosphatases Mediate the Inhibitory Effects of Alltrans Retinoic Acid on the Hypertrophic Growth of Cardiomyocytes, Diabetes. J. Biol. Chem, vol.55, issue.279, pp.281-290, 2004.

S. Yang, A. Galanis, and A. Sharrocks, Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors, Molecular and Cellular Biology, vol.19, issue.6, pp.4028-4038, 1999.
DOI : 10.1128/MCB.19.6.4028

A. Zetser, E. Gredinger, and E. Bengal, p38 Mitogen-activated Protein Kinase Pathway Promotes Skeletal Muscle Differentiation: PARTICIPATION OF THE MEF2C TRANSCRIPTION FACTOR, Journal of Biological Chemistry, vol.274, issue.8, pp.5193-200, 1999.
DOI : 10.1074/jbc.274.8.5193

M. Zhao, L. New, and V. Kravchenko, Regulation of the MEF2 Family of Transcription Factors by p38, Molecular and Cellular Biology, vol.19, issue.1, pp.21-30, 1999.
DOI : 10.1128/MCB.19.1.21

S. Davidson and M. Morange, Hsp25 and the p38 MAPK Pathway Are Involved in Differentiation of Cardiomyocytes, Developmental Biology, vol.218, issue.2, pp.146-60, 2000.
DOI : 10.1006/dbio.1999.9596

M. Eriksson and S. Leppa, Mitogen-activated Protein Kinases and Activator Protein 1 Are Required for Proliferation and Cardiomyocyte Differentiation of P19

R. Adams, A. Porras, and G. Alonso, Essential Role of p38?? MAP Kinase in Placental but Not Embryonic Cardiovascular Development, Molecular Cell, vol.6, issue.1, pp.109-125, 2000.
DOI : 10.1016/S1097-2765(05)00014-6

K. Takeda and H. Ichijo, Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system, Genes to Cells, vol.21, issue.11, pp.1099-111, 2002.
DOI : 10.1093/emboj/17.6.1740

S. Okamoto, D. Krainc, and K. Sherman, Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation, Proceedings of the National Academy of Sciences, vol.286, issue.5440, pp.7561-7566, 2000.
DOI : 10.1126/science.286.5440.785

D. Vaudry, P. Stork, and P. Lazarovici, Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections, Science, vol.296, issue.5573, pp.1648-1657, 2002.
DOI : 10.1126/science.1071552

M. Mcburney, P19 embryonal carcinoma cells, Int J Dev Biol, vol.37, pp.135-175, 1993.

I. Skerjanc, Cardiac and Skeletal Muscle Development in P19 Embryonal Carcinoma Cells, Trends in Cardiovascular Medicine, vol.9, issue.5, pp.139-143, 1999.
DOI : 10.1016/S1050-1738(99)00017-1

C. Kuan, D. Yang, and D. Roy, The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development, Neuron, vol.22, issue.4, pp.667-676, 1999.
DOI : 10.1016/S0896-6273(00)80727-8

K. Sabapathy, W. Jochum, and K. Hochedlinger, Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2, Mechanisms of Development, vol.89, issue.1-2, pp.115-124, 1999.
DOI : 10.1016/S0925-4773(99)00213-0

J. Hirosumi, G. Tuncman, and L. Chang, A central role for JNK in obesity and insulin resistance, Nature, vol.141, issue.6913, pp.333-339, 2002.
DOI : 10.1073/pnas.251194298

J. Aubert, H. Dunstan, and I. Chambers, Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation, Nature Biotechnology, vol.20, issue.12, pp.1240-1245, 2002.
DOI : 10.1038/nbt763

L. Haegele, B. Ingold, and H. Naumann, Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression, Molecular and Cellular Neuroscience, vol.24, issue.3
DOI : 10.1016/S1044-7431(03)00232-X

P. Xu, K. Yoshioka, and D. Yoshimura, In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1

. Galpha12, Galpha13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid, J Biol Chem, vol.272, pp.24468-74, 1997.

Y. Lee, C. Malbon, H. Wang, K. Kashef, H. Xu et al., G??13 Signals via p115RhoGEF Cascades Regulating JNK1 and Primitive Endoderm Formation, Journal of Biological Chemistry, vol.279, issue.52, pp.54896-904, 2004.
DOI : 10.1074/jbc.M407581200

L. Marek, V. Levresse, and C. Amura, Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells, Journal of Cellular Physiology, vol.277, issue.3, pp.459-69, 2004.
DOI : 10.1002/jcp.20087

L. Boyer, K. Plath, and J. Zeitlinger, Polycomb complexes repress developmental regulators in murine embryonic stem cells, Control of developmental regulators by Polycomb in human embryonic stem cells, pp.349-53, 2006.
DOI : 10.1016/0092-8674(92)90408-5

E. Lee, K. Mccool, and F. Murdoch, Dynamic Changes in Histone H3

L. Armstrong, O. Hughes, and S. Yung, The role of PI3K/AKT, MAPK/ERK and NF{kappa}{beta} signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis