Skip to Main content Skip to Navigation
Journal articles

Regulation of ES Cell Lineage Commitment by Mitogen Activated Protein Kinases: MAPKs and ES cell differentiation

Abstract : Embryonic Stem (ES) cells can give rise, in vivo, to the ectodermal, endodermal and mesodermal germ layers and, in vitro, can differentiate into multiple cell lineages, offering broad perspectives in regenerative medicine. Understanding the molecular mechanisms governing ES cell commitment is an essential challenge in this field. The Mitogen Activated Protein Kinase (MAPK) pathways, ERK, JNK and p38MAPK, are able to regulate ES commitment from early steps of the process to mature differentiated cells. Whereas the ERK pathway inhibits the self-renewal of ES cells, upon commitment this pathway is involved in the development of extraembryonic tissues, in early mesoderm differentiation and in the formation of mature adipocytes; p38MAPK displays a large spectrum of action from neurons to adipocytes and JNK is involved in both ectoderm and primitive endoderm differentiations. Furthermore, for a given pathway, several of these effects are isoform-dependent, revealing the complexity of the cellular response to activation of MAPK pathways. Regarding tissue regeneration, the potential outcome of systematic analysis of the function of different MAPKs in different ES cell differentiation programs is discussed.
Document type :
Journal articles
Complete list of metadatas

Cited literature [55 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00128753
Contributor : Bernard Binetruy <>
Submitted on : Friday, February 2, 2007 - 5:09:21 PM
Last modification on : Tuesday, May 26, 2020 - 6:50:23 PM
Long-term archiving on: : Wednesday, April 7, 2010 - 2:37:24 AM

Identifiers

Collections

Citation

Bernard Binetruy, Lynn Heasley, Frédéric Bost, Leslie Caron, Myriam Aouadi. Regulation of ES Cell Lineage Commitment by Mitogen Activated Protein Kinases: MAPKs and ES cell differentiation. Stem cells (Dayton, Ohio), 2007, pp.24. ⟨10.1634/stemcells.2006-0612⟩. ⟨inserm-00128753⟩

Share

Metrics

Record views

414

Files downloads

1618