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Dexamethasone impairs muscle energetics, studied by (31)P NMR, in rats.

Abstract : AIMS/HYPOTHESIS: Glucocorticoid treatments are associated with increased whole-body oxygen consumption. We hypothesised that an impairment of muscle energy metabolism can participate in this increased energy expenditure. METHODS: To investigate this possibility, we have studied muscle energetics of dexamethasone-treated rats (1.5 mg kg(-1) day(-1) for 6 days), in vivo by (31)P NMR spectroscopy. Results were compared with control and pair-fed (PF) rats before and after overnight fasting. RESULTS: Dexamethasone treatment resulted in decreased phosphocreatine (PCr) concentration and PCr:ATP ratio, increased ADP concentration and higher PCr to gamma-ATP flux but no change in beta-ATP to beta-ADP flux in gastrocnemius muscle. Neither 4 days of food restriction (PF rats) nor 24 h fasting affected high-energy phosphate metabolism. In dexamethasone-treated rats, there was an increase in plasma insulin and non-esterified fatty acid concentration. CONCLUSIONS/INTERPRETATION: We conclude that dexamethasone treatment altered resting in vivo skeletal muscle energy metabolism, by decreasing oxidative phosphorylation, producing ATP at the expense of PCr.
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Contributor : Jean-François Dumas Connect in order to contact the contributor
Submitted on : Thursday, February 1, 2007 - 6:53:38 PM
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Jean-François Dumas, Guy Bielicki, Jean-Pierre Renou, Delphine Roussel, Pierre-Henri Ducluzeau, et al.. Dexamethasone impairs muscle energetics, studied by (31)P NMR, in rats.. Diabetologia, Springer Verlag, 2005, 48 (2), pp.328-35. ⟨10.1007/s00125-004-1631-0⟩. ⟨inserm-00128573⟩



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