Skip to Main content Skip to Navigation
Journal articles

Food restriction affects energy metabolism in rat liver mitochondria.

Abstract : To examine the effect of 50% food restriction over a period of 3 days on mitochondrial energy metabolism, liver mitochondria were isolated from ad libitum and food-restricted rats. Mitochondrial enzyme activities and oxygen consumption were assessed spectrophotometrically and polarographically. With regard to body weight loss (-5%), food restriction decreased the liver to body mass ratio by 7%. Moreover, in food-restricted rats, liver mitochondria displayed diminished state 3 (-30%), state 4-oligomycin (-26%) and uncoupled state (-24%) respiration rates in the presence of succinate. Furthermore, "top-down" elasticity showed that these decreases were due to an inactivation of reactions involved in substrate oxidation. Therefore, it appears that rats not only adapt to food restriction through simple passive mechanisms, such as liver mass loss, but also through decreased mitochondrial energetic metabolism.
Document type :
Journal articles
Complete list of metadatas

Cited literature [19 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00128562
Contributor : Jean-François Dumas <>
Submitted on : Thursday, February 1, 2007 - 7:04:23 PM
Last modification on : Friday, July 6, 2007 - 11:14:04 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 8:42:19 PM

Identifiers

  • HAL Id : inserm-00128562, version 1
  • PUBMED : 14738995

Collections

Citation

Jean-François Dumas, Damien Roussel, Gilles Simard, Olivier Douay, Françoise Foussard, et al.. Food restriction affects energy metabolism in rat liver mitochondria.. BBA - Biochimica et Biophysica Acta, Elsevier, 2004, 1670 (2), pp.126-31. ⟨inserm-00128562⟩

Share

Metrics

Record views

271

Files downloads

1206