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Body silhouette, menstrual function at adolescence and breast cancer risk in the E3N cohort study.

Abstract : We analysed the relation between adult breast cancer risk and adiposity in ages 8-25, and among 90 509 women included in the E3N cohort study, and investigated the potential modification effect of certain factors. Participants completed a questionnaire that included a set of eight silhouettes corresponding to body shape at different ages. During the follow-up (mean=11.4 years), 3491 breast cancer cases were identified. Negative trends in risk of breast cancer with increasing body silhouettes at age 8 and at menarche were observed, irrespective of menopausal status, with relative risks of 0.73 (0.53-0.99) and 0.82 (0.66-1.02) for women who reported a silhouette equal or greater than the fifth silhouette at age 8 and at menarche, respectively. We observed no clear effect modification by age at menarche, delay between age at menarche, regular cycling, regularity of cycles in adult life or body mass index at baseline.
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https://www.hal.inserm.fr/inserm-00127340
Contributor : F. Clavel-Chapelon <>
Submitted on : Monday, January 29, 2007 - 5:08:25 PM
Last modification on : Wednesday, September 16, 2020 - 5:04:17 PM
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Bertrand Tehard, Rudolf Kaaks, Françoise Clavel-Chapelon. Body silhouette, menstrual function at adolescence and breast cancer risk in the E3N cohort study.. Breast Cancer Research and Treatment, Springer Verlag, 2005, 92 (11), pp.2042-8. ⟨10.1038/sj.bjc.6602620⟩. ⟨inserm-00127340⟩

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