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Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.

Abstract : Many studies have supported a genetic etiology for autism. Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism.
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https://www.hal.inserm.fr/inserm-00124744
Contributor : Catalina Betancur <>
Submitted on : Tuesday, January 16, 2007 - 9:31:17 AM
Last modification on : Wednesday, August 19, 2020 - 11:16:37 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 8:38:33 PM

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Stéphane Jamain, Hélène Quach, Catalina Betancur, Maria Råstam, Catherine Colineaux, et al.. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.. Nature Genetics, Nature Publishing Group, 2003, 34 (1), pp.27-9. ⟨10.1038/ng1136⟩. ⟨inserm-00124744⟩

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