Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Nature Genetics Année : 2003

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.

Résumé

Many studies have supported a genetic etiology for autism. Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism.

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Génétique
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Dates et versions

inserm-00124744 , version 1 (16-01-2007)

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Stéphane Jamain, Hélène Quach, Catalina Betancur, Maria Råstam, Catherine Colineaux, et al.. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.. Nature Genetics, 2003, 34 (1), pp.27-9. ⟨10.1038/ng1136⟩. ⟨inserm-00124744⟩
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