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[Could treatments with beta-blockers be associated with a reduction in cancer risk?]

Abstract : BACKGROUND: The relationship between the use of anti-hypertensive drugs and cancer risk remains controversial. The main objective of this study was to assess the potential effect of beta-blocker use on cancer risk. METHODS: In a cohort of 839 patients with cardiovascular disease, followed up prospectively for an average period of 10 years, cancer occurrence was recorded according to the exposure to beta-blockers. The relative risk of cancer associated with beta-blocker use was estimated using a Cox model adjusted on gender and age. Ever- vs never-use of beta-blockers and duration of exposure to the drug were analyzed as time-dependent variables. In addition, the standardized incidence ratios (SIR) were calculated using the corresponding age- and gender-adjusted cancer incidences in the French general population. RESULTS: A total of 326 beta-blocker users and 513 users of other treatments were included in the cohort. During the follow-up period, representing 8,466 person-years, incident cancer cases were 15 and 59 in beta-blocker ever-users versus never-users, respectively. Using the Cox model, the overall relative risk of cancer was 0.51 (95% confidence interval [95% CI]: 0.29-0.90) in the beta-blocker ever-users versus never-users (p=0.02), with a 6% decrease per year of use (95% CI: 1%-12%; p=0.03). The corresponding SIR ratio between these two groups was 0.44 (95% CI: 0.24-0.76). CONCLUSION: In this cohort, the beta-blocker treatments appeared to decrease the cancer risk significantly. However, this result should be considered with caution; further work is needed, as some sources of bias associated with this type of epidemiological study cannot be totally excluded.
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https://www.hal.inserm.fr/inserm-00122277
Contributor : Marie-Gabrielle Dondon <>
Submitted on : Thursday, December 28, 2006 - 7:58:53 PM
Last modification on : Saturday, December 15, 2018 - 1:31:03 AM

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  • HAL Id : inserm-00122277, version 1
  • PUBMED : 15107693

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M. Algazi, G. Plu-Bureau, A. Flahault, Marie-Gabrielle Dondon, M. G. Lê. [Could treatments with beta-blockers be associated with a reduction in cancer risk?]. Epidemiology and Public Health / Revue d'Epidémiologie et de Santé Publique, Elsevier Masson, 2004, 52, pp.53-65. ⟨inserm-00122277⟩

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