M. Beckmann, D. Niederacher, H. Schnurch, B. Gusterson, and H. Bender, Multistep carcinogenesis of breast cancer and tumour heterogeneity, Journal of Molecular Medicine, vol.75, issue.6, pp.429-439, 1997.
DOI : 10.1007/s001090050128

M. Tanner, M. Tirkkonen, A. Kallioniemi, J. Isola, T. Kuukasjarvi et al., Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer, Cancer Res, issue.15, pp.563441-3445, 1996.

M. Cuny, A. Kramar, F. Courjal, V. Johannsdottir, B. Iacopetta et al., Relating genotype and phenotype in breast cancer: an analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations, Cancer Res, vol.60, issue.4, pp.1077-1083, 2000.

K. Al-kuraya, P. Schraml, J. Torhorst, C. Tapia, B. Zaharieva et al., Prognostic Relevance of Gene Amplifications and Coamplifications in Breast Cancer, Cancer Research, vol.64, issue.23, pp.648534-8540, 2004.
DOI : 10.1158/0008-5472.CAN-04-1945

V. Gelsi-boyer, B. Orsetti, N. Cervera, P. Finetti, F. Sircoulomb et al., Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer, Molecular Cancer Research, vol.3, issue.12, pp.655-667, 2005.
DOI : 10.1158/1541-7786.MCR-05-0128
URL : https://hal.archives-ouvertes.fr/inserm-00158812

A. Dib, A. J. Coujal, F. Courseaux, A. Jacquemier, J. Gaudray et al., Co-amplification in human breast tumors and physical linkage at chromosomal band 12p13, of CCND2 and FGF6 genes, International Journal of Oncology, vol.5, pp.1375-1378, 1994.

J. Yao, S. Weremowicz, B. Feng, R. Gentleman, J. Marks et al., Combined cDNA Array Comparative Genomic Hybridization and Serial Analysis of Gene Expression Analysis of Breast Tumor Progression, Cancer Research, vol.66, issue.8, pp.664065-4078, 2006.
DOI : 10.1158/0008-5472.CAN-05-4083

D. Slamon, G. Clark, S. Wong, W. Levin, A. Ullrich et al., Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene, Science, vol.235, issue.4785, pp.235177-182, 1987.
DOI : 10.1126/science.3798106

O. Kallioniemi, A. Kallioniemi, W. Kurisu, A. Thor, L. Chen et al., ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization., Proceedings of the National Academy of Sciences, vol.89, issue.12, pp.895321-5325, 1992.
DOI : 10.1073/pnas.89.12.5321

C. Vogel, M. Cobleigh, D. Tripathy, J. Gutheil, L. Harris et al., -Overexpressing Metastatic Breast Cancer, Journal of Clinical Oncology, vol.20, issue.3, pp.719-726, 2002.
DOI : 10.1200/JCO.2002.20.3.719
URL : https://hal.archives-ouvertes.fr/hal-00159653

C. Theillet, A. J. Louason, G. Bonnet-dorion, F. Jacquemier, J. Adnane et al., FGFRI andPLAT genes and DNA amplification at 8p 12 in breast and ovarian cancers, Genes, Chromosomes and Cancer, vol.4, issue.4, pp.219-226, 1993.
DOI : 10.1002/gcc.2870070407

F. Courjal and C. Theillet, Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification, Cancer Res, vol.57, pp.4368-4377, 1997.

J. Adelaide, M. Chaffanet, A. Imbert, F. Allione, J. Geneix et al., Chromosome region 8p11-p21: Refined mapping and molecular alterations in breast cancer, Genes, Chromosomes and Cancer, vol.35, issue.3, pp.186-199, 1998.
DOI : 10.1002/(SICI)1098-2264(199807)22:3<186::AID-GCC4>3.0.CO;2-S

F. Ugolini, A. J. Charafe-jauffret, E. Nguyen, C. Jacquemier, J. Jordan et al., Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes, Oncogene, vol.18, issue.10, pp.181903-1910, 1999.
DOI : 10.1038/sj.onc.1202739

M. Bonilla, M. Ramirez, J. Lopez-cueto, and P. Gariglio, In Vivo Amplification and Rearrangement of c-myc Oncogene in Human Breast Tumors, JNCI Journal of the National Cancer Institute, vol.80, issue.9, pp.665-671, 1988.
DOI : 10.1093/jnci/80.9.665

E. Berns, J. Klijn, W. Van-putten, I. Van-staveren, H. Portengen et al., c-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer, Cancer Res, vol.52, issue.5, pp.1107-1113, 1992.

E. Berns, J. Foekens, W. Van-putten, I. Van-staveren, H. Portengen et al., Prognostic factors in human primary breast cancer: Comparison of c-myc and HER2/neu amplification, The Journal of Steroid Biochemistry and Molecular Biology, vol.43, issue.1-3, pp.1-313, 1992.
DOI : 10.1016/0960-0760(92)90182-I

M. Roux-dosseto, R. S. Dussault, N. Desideri, C. Piana, L. Bonnier et al., c-myc gene amplification in selected node-negative breast cancer patients correlates with high rate of early relapse, European Journal of Cancer, vol.28, issue.10, pp.28-1600, 1992.
DOI : 10.1016/0959-8049(92)90050-C

S. Deming, S. Nass, R. Dickson, and B. Trock, C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance, British Journal of Cancer, vol.83, issue.12, pp.1688-1695, 2000.
DOI : 10.1054/bjoc.2000.1522

C. Schlotter, U. Vogt, U. Bosse, B. Mersch, and K. Wassmann, C-myc, not HER-2/neu, can predict recurrence and mortality of patients with node-negative breast cancer, Breast Cancer Research, vol.24, issue.2, pp.30-36, 2003.
DOI : 10.1007/BF01833260

S. Aulmann, N. Adler, J. Rom, B. Helmchen, P. Schirmacher et al., c-myc Amplifications in primary breast carcinomas and their local recurrences, Journal of Clinical Pathology, vol.59, issue.4, pp.424-428, 2006.
DOI : 10.1136/jcp.2005.029264

R. Seshadri, C. Lee, R. Hui, K. Mccaul, D. Horsfall et al., Cyclin DI amplification is not associated with reduced overall survival in primary breast cancer but may predict early relapse in patients with features of good prognosis, Clin Cancer Res, vol.2, issue.7, pp.1177-1184, 1996.

J. Kononen, L. Bubendorf, A. Kallioniemi, M. Barlund, P. Schraml et al., Tissue microarrays for high-throughput molecular profiling of tumor specimens, Nature Medicine, vol.54, issue.7, pp.844-847, 1998.
DOI : 10.1023/A:1005769925670

R. Naidu, N. Wahab, M. Yadav, and M. Kutty, Expression and amplification of cyclin D1 in primary breast carcinomas: Relationship with histopathological types and clinico-pathological parameters, Oncology Reports, vol.9, issue.2, pp.409-416, 2002.
DOI : 10.3892/or.9.2.409

F. Bertucci, P. Finetti, N. Cervera, E. Charafe-jauffret, E. Mamessier et al., Gene Expression Profiling Shows Medullary Breast Cancer Is a Subgroup of Basal Breast Cancers, Cancer Research, vol.66, issue.9, pp.664636-4644, 2006.
DOI : 10.1158/0008-5472.CAN-06-0031

J. Isola, O. Kallioniemi, L. Chu, S. Fuqua, S. Hilsenbeck et al., Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer, Am J Pathol, vol.147, issue.4, pp.905-911, 1995.

M. Tanner, M. Tirkkonen, A. Kallioniemi, K. Holli, C. Collins et al., Amplification of chromosomal region 20q13 in invasive breast cancer: prognostic implications, Clin Cancer Res, vol.1, issue.12, pp.1455-1461, 1995.

J. Hodgson, K. Chin, C. Collins, and J. Gray, Genome Amplification of Chromosome 20 in Breast Cancer, Breast Cancer Research and Treatment, vol.6, issue.3, pp.337-345, 2003.
DOI : 10.1023/A:1023085825042

C. Ginestier, N. Cervera, P. Finetti, S. Esteyries, B. Esterni et al., Prognosis and Gene Expression Profiling of 20q13-Amplified Breast Cancers, Clinical Cancer Research, vol.12, issue.15, pp.124533-4544, 2006.
DOI : 10.1158/1078-0432.CCR-05-2339
URL : https://hal.archives-ouvertes.fr/hal-01431971

F. Forozan, E. Mahlamaki, O. Monni, Y. Chen, R. Veldman et al., Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data, Cancer Res, issue.16, pp.604519-4525, 2000.

S. Sen, H. Zhou, and R. White, A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines, Oncogene, vol.14, issue.18, pp.2195-2200, 1997.
DOI : 10.1038/sj.onc.1201065

G. Nonet, M. Stampfer, K. Chin, J. Gray, C. Collins et al., The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells, Cancer Res, vol.61, issue.4, pp.1250-1254, 2001.

G. Huang, S. Krig, D. Kowbel, H. Xu, H. B. Volik et al., ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction, Human Molecular Genetics, vol.14, issue.21, pp.217-143219, 2005.
DOI : 10.1093/hmg/ddi352

C. Ginestier, E. Charafe-jauffret, F. Bertucci, F. Eisinger, J. Geneix et al., Distinct and Complementary Information Provided by Use of Tissue and DNA Microarrays in the Study of Breast Tumor Markers, The American Journal of Pathology, vol.161, issue.4, pp.1223-1233, 2002.
DOI : 10.1016/S0002-9440(10)64399-4

S. Chin, Y. Daigo, H. Huang, N. Iyer, G. Callagy et al., A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumour samples, Molecular Pathology, vol.56, issue.5, pp.56275-279, 2003.
DOI : 10.1136/mp.56.5.275

T. Huang, B. Huang, Q. Liang, and C. Huang, Fang Y: Dual fluorescence in situ hybridization in detection of HER-2 oncogene amplification in primary hepatocellular carcinoma, Hepatobiliary Pancreat Dis Int, vol.3, issue.1, pp.62-68, 2004.

C. Perou, T. Sorlie, M. Eisen, M. Van-de-rijn, S. Jeffrey et al., Molecular portraits of human breast tumours, Nature, issue.6797, pp.406747-752, 2000.

T. Sorlie, R. Tibshirani, J. Parker, T. Hastie, J. Marron et al., Repeated observation of breast tumor subtypes in independent gene expression data sets, Proceedings of the National Academy of Sciences, vol.360, issue.9338, pp.1008418-8423, 2003.
DOI : 10.1016/S0140-6736(02)11087-7

J. Gray, C. Collins, I. Henderson, J. Isola, A. Kallioniemi et al., Molecular Cytogenetics of Human Breast Cancer, Cold Spring Harbor Symposia on Quantitative Biology, vol.59, issue.0, pp.645-652, 1994.
DOI : 10.1101/SQB.1994.059.01.074

G. Pauletti, S. Dandekar, H. Rong, L. Ramos, H. Peng et al., Assessment of Methods for Tissue-Based Detection of the HER-2/neu Alteration in Human Breast Cancer: A Direct Comparison of Fluorescence In Situ Hybridization and Immunohistochemistry, Journal of Clinical Oncology, vol.18, issue.21, pp.183651-3664, 2000.
DOI : 10.1200/JCO.2000.18.21.3651

M. Ray, Z. Yang, D. Albertson, C. Kleer, J. Washburn et al., Genomic and Expression Analysis of the 8p11-12 Amplicon in Human Breast Cancer Cell Lines, Cancer Research, vol.64, issue.1, pp.40-47, 2004.
DOI : 10.1158/0008-5472.CAN-03-1022

M. Garcia, J. Pole, S. Chin, A. Teschendorff, A. Naderi et al., A 1???Mb minimal amplicon at 8p11???12 in breast cancer identifies new candidate oncogenes, Oncogene, vol.56, issue.33, pp.245235-5245, 2005.
DOI : 10.1093/nar/30.10.e48

L. Prentice, A. Shadeo, V. Lestou, M. Miller, R. Makretsov et al., NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis, Oncogene, vol.2, issue.49, pp.1-247281, 2005.
DOI : 10.1038/sj.onc.1208892

F. Courjal, M. Cuny, J. Simony-lafontaine, G. Louason, P. Speiser et al., Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups, Cancer Res, issue.19, pp.574360-4367, 1997.

S. Bautista and C. Theillet, CCND1 and FGFR1 coamplification results in the colocalization of 11q13 and 8p12 sequences in breast tumor nuclei, Genes, Chromosomes and Cancer, vol.22, issue.4, pp.268-277, 1998.
DOI : 10.1002/(SICI)1098-2264(199808)22:4<268::AID-GCC2>3.3.CO;2-U

P. Schraml, J. Kononen, L. Bubendorf, H. Moch, H. Bissig et al., Tissue microarrays for gene amplification surveys in many different tumor types, Clin Cancer Res, vol.5, issue.8, pp.1966-1975, 1999.

J. Rummukainen, T. Salminen, J. Lundin, S. Kytola, H. Joensuu et al., Amplification of c-myc by Fluorescence In Situ Hybridization in a Population-Based Breast Cancer Tissue Array, Modern Pathology, vol.14, issue.10, pp.141030-1035, 2001.
DOI : 10.1038/modpathol.3880431

D. Dubik and R. Shiu, Transcriptional regulation of c-myc oncogene expression by estrogen in hormone-responsive human breast cancer cells, J Biol Chem, vol.263, issue.25, pp.12705-12708, 1988.

G. Santos, G. Scott, W. Lee, E. Liu, and C. Benz, Estrogen-induced post-transcriptional modulation of c-myc proto-oncogene expression in human breast cancer cells, J Biol Chem, issue.20, pp.2639565-9568, 1988.

B. Van-der-burg, A. Van-selm-miltenburg, S. De-laat, and E. Van-zoelen, Direct effects of estrogen on c-fos and c-myc protooncogene expression and cellular proliferation in human breast cancer cells, Molecular and Cellular Endocrinology, vol.64, issue.2, pp.223-228, 1989.
DOI : 10.1016/0303-7207(89)90149-4

L. Roy, X. Escot, C. Brouillet, J. Theillet, C. Maudelonde et al., Decrease of c-erbB-2 and cmyc RNA levels in tamoxifen-treated breast cancer, Oncogene, vol.6, issue.3, pp.431-437, 1991.

R. Naidu, N. Wahab, M. Yadav, and M. Kutty, Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction, International Journal of Molecular Medicine, vol.9, issue.2, pp.189-196, 2002.
DOI : 10.3892/ijmm.9.2.189

J. Varley, J. Swallow, W. Brammar, J. Whittaker, and R. Walker, Alterations to either c-erbB-2 (neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis, Oncogene, vol.1, pp.423-430, 1987.

E. Berns, J. Klijn, I. Van-staveren, H. Portengen, E. Noordegraaf et al., Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: Correlation with steroid receptors, European Journal of Cancer, vol.28, issue.2-3, pp.697-700, 1992.
DOI : 10.1016/S0959-8049(05)80129-7

K. Park, K. Kwak, J. Kim, S. Lim, and S. Han, c-myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers, Human Pathology, vol.36, issue.6, pp.634-639, 2005.
DOI : 10.1016/j.humpath.2005.04.016

J. Karlseder, R. Zeillinger, C. Schneeberger, K. Czerwenka, P. Speiser et al., Patterns of dna amplification at band q13 of chromosome 11 in human breast cancer, Genes, Chromosomes and Cancer, vol.4, issue.1, pp.42-48, 1994.
DOI : 10.1002/gcc.2870090108

C. Ormandy, E. Musgrove, R. Hui, R. Daly, and R. Sutherland, Cyclin D1, EMS1 and 11q13 Amplification in Breast Cancer, Breast Cancer Research and Treatment, vol.272, issue.suppl, pp.323-335, 2003.
DOI : 10.1023/A:1023033708204

T. Wang, R. Cardiff, L. Zukerberg, E. Lees, A. Arnold et al., Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice, Nature, vol.369, issue.6482, pp.369669-671, 1994.
DOI : 10.1038/369669a0

I. Bieche, M. Olivi, C. Nogues, M. Vidaud, and R. Lidereau, Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays, British Journal of Cancer, vol.12, issue.4, pp.580-586, 2002.
DOI : 10.1038/sj.bjc.6600109

O. Henegariu, G. Vance, D. Heiber, M. Pera, and N. Heerema, Triple-color FISH analysis of 12p amplification in testicular germ-cell tumors using 12p band-specific painting probes, Journal of Molecular Medicine, vol.76, issue.9, pp.648-655, 1998.
DOI : 10.1007/s001090050262

B. Summersgill, H. Goker, S. Weber-hall, R. Huddart, A. Horwich et al., Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of regions of consensus copy number change, British Journal of Cancer, vol.77, issue.2, pp.305-313, 1998.
DOI : 10.1038/bjc.1998.47

L. Looijenga and J. Oosterhuis, Pathogenesis of testicular germ cell tumours, Reviews of Reproduction, vol.4, issue.2, pp.90-100, 1999.
DOI : 10.1530/ror.0.0040090

C. Rosenberg, V. Gurp, R. Geelen, E. Oosterhuis, J. Looijenga et al., Overrepresentation of the short arm of chromosome 12 is related to invasive growth of human testicular seminomas and nonseminomas, Oncogene, vol.19, issue.51, pp.5858-5862, 2000.
DOI : 10.1038/sj.onc.1203950

U. Ezeh, P. Turek, R. Reijo, and A. Clark, Human embryonic stem cell genesOCT4, NANOG, STELLAR, andGDF3 are expressed in both seminoma and breast carcinoma, Cancer, vol.119, issue.10, pp.2255-2265, 2005.
DOI : 10.1002/cncr.21432

J. Korkola, J. Houldsworth, R. Chadalavada, A. Olshen, D. Dobrzynski et al., Down-Regulation of Stem Cell Genes, Including Those in a 200-kb Gene Cluster at 12p13.31, Is Associated with In vivo Differentiation of Human Male Germ Cell Tumors, Cancer Research, vol.66, issue.2, pp.820-827, 2006.
DOI : 10.1158/0008-5472.CAN-05-2445

P. Mcgrath, D. Holley, L. Hamby, D. Powell, C. Mattingly et al., Proliferation-associated nucleolar antigen P120: a prognostic marker in node-negative breast cancer, Surgery, vol.1161, issue.20, pp.616-636, 1994.

I. Garcia, P. Dietrich, M. Aapro, G. Vauthier, L. Vadas et al., Genetic alterations of c-myc, c-erbB-2, and c-Ha-ras protooncogenes and clinical associations in human breast carcinomas, Cancer Res, issue.23, pp.496675-6679, 1989.

N. Quenel, J. Wafflart, F. Bonichon, I. De-mascarel, M. Trojani et al., The prognostic value of c-erbB2 in primary breast carcinomas: A study on 942 cases, Breast Cancer Research and Treatment, vol.1, issue.3, pp.283-291, 1995.
DOI : 10.1007/BF00665980

M. Press, L. Bernstein, P. Thomas, L. Meisner, J. Zhou et al., HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas., Journal of Clinical Oncology, vol.15, issue.8, pp.152894-2904, 1997.
DOI : 10.1200/JCO.1997.15.8.2894

S. Kakar, N. Puangsuvan, J. Stevens, R. Serenas, G. Mangan et al., HER-2/neu Assessment in Breast Cancer by Immunohistochemistry and Fluorescence In Situ Hybridization: Comparison of Results and Correlation With Survival, Molecular Diagnosis, vol.5, issue.3, pp.199-207, 2000.
DOI : 10.2165/00066982-200005030-00006

L. Melchor, S. Alvarez, E. Honrado, J. Palacios, A. Barroso et al., The Accumulation of Specific Amplifications Characterizes Two Different Genomic Pathways of Evolution of Familial Breast Tumors, Clinical Cancer Research, vol.11, issue.24, pp.8577-8584, 2005.
DOI : 10.1158/1078-0432.CCR-05-1278

J. Reis-filho, K. Savage, M. Lambros, M. James, D. Steele et al., Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysis, Modern Pathology, vol.442, issue.7, pp.999-1009, 2006.
DOI : 10.1002/(SICI)1096-9896(199607)179:3<238::AID-PATH566>3.3.CO;2-N