D. Clancy, D. Gems, L. Harshman, S. Oldham, H. Stocker et al., Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein, Science, vol.292, issue.5514, pp.104-106, 2001.
DOI : 10.1126/science.1057991

L. Guarente and C. Kenyon, Genetic pathways that regulate ageing in model organisms, Nature, vol.408, issue.6809, pp.255-262, 2000.
DOI : 10.1038/35041700

S. Lamberts, A. Van-den-beld, and A. Van-der-lely, The Endocrinology of Aging, Science, vol.278, issue.5337, pp.419-424, 1997.
DOI : 10.1126/science.278.5337.419

S. Ogg, S. Paradis, S. Gottlieb, G. Patterson, L. Lee et al., The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans, Nature, vol.389, pp.994-999, 1997.

M. Tatar, A. Kopelman, D. Epstein, M. Tu, C. Yin et al., A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function, Science, vol.292, issue.5514, pp.107-110, 2001.
DOI : 10.1126/science.1057987

I. Shimokawa, Y. Higami, M. Utsuyama, T. Tuchiya, T. Komatsu et al., Life Span Extension by Reduction in Growth Hormone-Insulin-Like Growth Factor-1 Axis in a Transgenic Rat Model, The American Journal of Pathology, vol.160, issue.6, pp.2259-2265, 2002.
DOI : 10.1016/S0002-9440(10)61173-X

A. Bartke, H. Brown-borg, A. Bode, J. Carlson, W. Hunter et al., Does growth hormone prevent or accelerate aging?, Experimental Gerontology, vol.33, issue.7-8, pp.675-687, 1998.
DOI : 10.1016/S0531-5565(98)00032-1

K. Flurkey, J. Papaconstantinou, R. Miller, and D. Harrison, Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production, Proceedings of the National Academy of Sciences, vol.250, issue.4981, pp.6736-6741, 2001.
DOI : 10.1126/science.2237414

K. Coschigano, D. Clemmons, L. Bellush, and J. Kopchick, Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice, Endocrinology, vol.141, issue.7, pp.2608-2613, 2000.
DOI : 10.1210/en.141.7.2608

K. Flurkey, J. Papaconstantinou, and D. Harrison, The Snell dwarf mutation Pit1dw can increase life span in mice, Mechanisms of Ageing and Development, vol.123, issue.2-3, pp.121-130, 2002.
DOI : 10.1016/S0047-6374(01)00339-6

M. Holzenberger, J. Dupont, B. Ducos, P. Leneuve, A. Geloen et al., IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice, Nature, vol.959, issue.6919, pp.182-187, 2003.
DOI : 10.1074/jbc.M006741200

A. Iranmanesh, G. Lizarralde, and J. Veldhuis, Age and Relative Adiposity Are Specific Negative Determinants of the Frequency and Amplitude of Growth Hormone (GH) Secretory Bursts and the Half-Life of Endogenous GH in Healthy Men*, The Journal of Clinical Endocrinology & Metabolism, vol.73, issue.5, pp.1081-1088, 1991.
DOI : 10.1210/jcem-73-5-1081

B. Velasco, L. Cacicedo, J. Escalada, J. Ló-pez-fernandez, and F. Sanchez-franco, Growth Hormone Gene Expression and Secretion in Aging Rats Is Age Dependent and Not Age-Associated Weight Increase Related, Endocrinology, vol.139, issue.3, pp.1314-1320, 1998.
DOI : 10.1210/en.139.3.1314

W. Sonntag, X. Xu, R. Ingram, and D. Costa, Moderate Caloric Restriction Alters the Subcellular Distribution of Somatostatin mRNA and Increases Growth Hormone Pulse Amplitude in Aged Animals, Neuroendocrinology, vol.61, issue.5, pp.601-608, 1995.
DOI : 10.1159/000126885

N. Girard, G. Ferland, L. Boulanger, and P. Gaudreau, Long-Term Calorie Restriction Protects Rat Pituitary Growth Hormone-Releasing Hormone Binding Sites from Age-Related Alterations, Neuroendocrinology, vol.68, issue.1, pp.21-29, 1998.
DOI : 10.1159/000054346

A. Bartke, J. Wright, J. Mattison, D. Ingram, R. Miller et al., Longevity: Extending the lifespan of long-lived mice, Nature, vol.292, issue.6862, p.412, 2001.
DOI : 10.1038/35106646

I. Shimokawa, Y. Higami, T. Tsuchiya, H. Otani, T. Komatsu et al., Life span extension by reduction of the growth hormoneinsulin-like growth factor-1 axis: Relation to caloric restriction, FASEB J, vol.17, pp.1108-1109, 2003.

H. Bazin, The Louvain (Lou) rats; in Bazin H (ed): Rat Hybridomas and Rat Monoclonal Antibodies, Boca Raton, 1990.

J. Alliot, S. Boghossian, J. D. Veyrat-durebex, C. Pickering, G. Meynial-denis et al., The LOU/c/jall Rat as an Animal Model of Healthy Aging?, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.57, issue.8, pp.312-320, 2002.
DOI : 10.1093/gerona/57.8.B312

V. Dodane, C. J. Bariety, J. Pratz, J. Corman, and B. , Longitudinal study of solute excretion and glomerular ultrastructure in an experimental model of aging rats free of kidney disease, Lab Invest, vol.64, pp.377-391, 1991.

S. Boghossian, N. Nguema, G. , J. D. Alliot, and J. , Old as mature LOU/c/jall rats enhance protein selection in response to a protein deprivation, Experimental Gerontology, vol.37, issue.12, pp.1431-1440, 2002.
DOI : 10.1016/S0531-5565(02)00174-2

C. Hsieh, J. Deford, K. Flurkey, D. Harrison, and J. Papaconstantinou, Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm, Mechanisms of Ageing and Development, vol.123, issue.9, pp.1229-1244, 2002.
DOI : 10.1016/S0047-6374(02)00036-2

V. Tolle, M. Bassant, P. Zizzari, F. Poindessous-jazat, C. Tomasetto et al., Ultradian Rhythmicity of Ghrelin Secretion in Relation with GH, Feeding Behavior, and Sleep-Wake Patterns in Rats, Endocrinology, vol.143, issue.4, pp.1353-1361, 2002.
DOI : 10.1210/endo.143.4.8712

F. Newby, M. Digirolamo, G. Cotsonis, and M. Kutner, Model of spontaneous obesity in aging male Wistar rats, Am J Physiol, vol.259, issue.6 2, pp.1117-1125, 1990.

M. Bluet-pajot, D. Durand, S. Drouva, F. Mounier, M. Pressac et al., Further Evidence That Thyrotropin-Releasing Hormone Participates in the Regulation of Growth Hormone Secretion in the Rat, Neuroendocrinology, vol.44, issue.1, pp.70-75, 1986.
DOI : 10.1159/000124624

E. Ezan, E. Laplante, M. Bluet-pajot, F. Mounier, S. Mamas et al., An Enzyme Immunoassay for Rat Growth Hormone: Validation and Application to the Determination of Plasma Levels and in Vitro Release, Journal of Immunoassay, vol.9, issue.4, pp.335-356, 1997.
DOI : 10.3109/00365519009085803

S. Hilsenbeck, W. Friedrichs, R. Schiff, O. Connell, P. Hansen et al., Statistical Analysis of Array Expression Data as Applied to the Problem of Tamoxifen Resistance, JNCI Journal of the National Cancer Institute, vol.91, issue.5, pp.453-459, 1999.
DOI : 10.1093/jnci/91.5.453

R. Miller, A. Galecki, and R. Shmookler-reis, Interpretation, Design, and Analysis of Gene Array Expression Experiments, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.56, issue.2, pp.52-57, 2001.
DOI : 10.1093/gerona/56.2.B52

E. Han and S. Hilsenbeck, Array-based gene expression profiling to study aging, Mechanisms of Ageing and Development, vol.122, issue.10, pp.999-1018, 2001.
DOI : 10.1016/S0047-6374(01)00215-9

D. 30-goidin, L. Kappeler, J. Perrot, J. Epelbaum, and D. Gourdji, Differential Pituitary Gene Expression Profiles Associated- To Aging and Spontaneous Tumors as Revealed by cDNA Expression Array, Endocrinology, vol.141, issue.12, pp.4805-4808, 2000.
DOI : 10.1210/endo.141.12.7950

L. Kappeler, D. Gourdji, P. Zizzari, M. Bluet-pajot, and J. Epelbaum, Age-Associated Changes in Hypothalamic and Pituitary Neuroendocrine Gene Expression in the Rat, Journal of Neuroendocrinology, vol.25, issue.Suppl. 1, pp.592-601, 2003.
DOI : 10.1046/j.1365-2826.2003.01039.x

J. Veldhuis and M. Johnson, Cluster analysis: A simple, versatile, and robust algorithm for endocrine pulse detection, Am J Physiol, vol.250, issue.4, pp.486-493, 1986.

C. Veyrat-durebex, P. Gaudreau, S. Boghossian, and J. Alliot, Effects of peripheral and central administration of GHRH on feeding in aging LOU rats, Peptides, vol.22, issue.12, pp.2119-2126, 2001.
DOI : 10.1016/S0196-9781(01)00560-5

B. Velasco, L. Cacicedo, E. Melian, G. Fernandez-vazquez, and F. Sanchez-franco, Sensitivity to exogenous GH and reversibility of the reduced IGF-I gene expression in aging rats, European Journal of Endocrinology, vol.145, issue.1, pp.73-85, 2001.
DOI : 10.1530/eje.0.1450073

S. Severgnini, D. Lowenthal, W. Millard, F. Simmen, B. Pollock et al., Altered IGF-I and IGFBPs in Senescent Male and Female Rats, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.54, issue.3, pp.111-115, 1999.
DOI : 10.1093/gerona/54.3.B111

P. Scarpace, M. Matheny, and R. Moore, Impaired leptin responsiveness in aged rats, Diabetes, vol.49, issue.3, pp.431-435, 2000.
DOI : 10.2337/diabetes.49.3.431

E. Shek and P. Scarpace, Resistance to the anorexic and thermogenic effects of centrally administrated leptin in obese aged rats, Regulatory Peptides, vol.92, issue.1-3, pp.65-71, 2000.
DOI : 10.1016/S0167-0115(00)00151-8

M. Tschop, C. Weyer, P. Tataranni, V. Devanarayan, E. Ravussin et al., Circulating Ghrelin Levels Are Decreased in Human Obesity, Diabetes, vol.50, issue.4, pp.707-709, 2001.
DOI : 10.2337/diabetes.50.4.707

G. Greeley and E. Englander, Increased stomach ghrelin expression and secretion in aged rats (abstract), 2003.

J. Davis, The advancing age on the oxygen consumption of rats, Am J Physiol, vol.119, pp.28-33, 1937.

R. Mccarter and J. Palmer, Energy metabolism and aging: A lifelong study of Fischer 344 rats, Am J Physiol, vol.263, issue.3, pp.448-452, 1992.

M. Bassant, F. Jazat-poindessous, L. Kappeler, M. Bluet-pajot, J. Alliot et al., Abnormalities in sleep patterns and orexin neurons in Lou C/Jall rats, a strain with long life expectancy (abstract), 2002.