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Donepezil restores GH secretion in old rats without affecting the sleep/wake cycle.

Abstract : A chronic treatment with a cholinesterase inhibitor, donepezil (0.085 mg/kg/h for 30 days) increases significantly the number and amplitude of growth hormone (GH) pulses in 3- and 24-month-old rats without modifying nadir GH values. This treatment does not reduce age-related alterations in sleep/wake cycle but it increases immobility-related high-voltage spindles (HVS) in old animals. These data suggest that cholinergic mechanisms involved in age-related alterations in GH and sleep regulation are different.
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https://www.hal.inserm.fr/inserm-00117240
Contributor : Philippe Zizzari <>
Submitted on : Thursday, November 30, 2006 - 4:07:06 PM
Last modification on : Friday, March 27, 2020 - 2:21:42 AM
Long-term archiving on: : Friday, November 25, 2016 - 1:23:52 PM

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Philippe Zizzari, Marie-Hélène Bassant, Frédérique Poindessous-Jazat, Jacques Epelbaum, Marie-Thérèse Bluet-Pajot. Donepezil restores GH secretion in old rats without affecting the sleep/wake cycle.. Neurobiol Aging, 2006, 27 (5), pp.784.e1-784.e5. ⟨10.1016/j.neurobiolaging.2005.07.011⟩. ⟨inserm-00117240⟩

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