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Increased power to detect gene-environment interaction using siblings controls.: GxE interaction and siblings controls

Abstract : PURPOSE: Interest is increasing in studying gene-environment (G x E) interaction in disease etiology. Study designs using related controls as a more appropriate control group for evaluating G x E interactions have been proposed but often assume unrealistic numbers of available relative controls. To evaluate a more realistic design, we studied the relative efficiency of a 1:0.5 case-sibling-control design compared with a classical 1:1 case-unrelated-control design and examined the effect of the analysis strategy. METHODS: Simulations were performed to assess the efficiency of a 1:0.5 case-sibling-control design relative to a classical 1:1 case-unrelated-control design under a variety of assumptions for estimating G x E interaction. Both matched and unmatched analysis strategies were examined. RESULTS: When using a matched analysis, the 1:1 case-unrelated-control design was almost always more powerful than the 1:0.5 case-sibling-control design. In contrast, when using an unmatched analysis, the 1:0.5 case-sibling-control design was almost always more powerful than the 1:1 case-unrelated-control design. The unconditional analysis of the case-sibling-control design to estimate G x E interaction, however, requires no correlation in E between siblings. CONCLUSIONS: In most settings, a matched analysis may be required and a 1:1 case-unrelated-control design will be more powerful than a 1:0.5 case-sibling-control design.
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https://www.hal.inserm.fr/inserm-00117223
Contributor : Marie-Gabrielle Dondon <>
Submitted on : Monday, July 2, 2007 - 9:59:45 AM
Last modification on : Tuesday, July 21, 2020 - 3:58:35 AM
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Nadine Andrieu, Marie-Gabrielle Dondon, Alisa Goldstein. Increased power to detect gene-environment interaction using siblings controls.: GxE interaction and siblings controls. Annals of Epidemiology, Elsevier Masson, 2005, 15 (9), pp.705-11. ⟨10.1016/j.annepidem.2005.01.002⟩. ⟨inserm-00117223⟩

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