S. Burma, B. Chen, M. Murphy, A. Kurimasa, and D. Chen, ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks, Journal of Biological Chemistry, vol.276, issue.45, pp.42462-42467, 2001.
DOI : 10.1074/jbc.C100466200

Y. Andegeko, L. Moyal, L. Mittelman, I. Tsarfaty, Y. Shiloh et al., Nuclear retention of ATM at sites of DNA double strand breaks, J Biol Chem, vol.276, pp.38224-38230, 2001.

G. Taccioli, T. Gottlieb, T. Blunt, A. Priestley, J. Demengeot et al., Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination, Science, vol.265, issue.5177, pp.1442-1445, 1994.
DOI : 10.1126/science.8073286

X. Wu and M. Lieber, Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86., Molecular and Cellular Biology, vol.16, issue.9, pp.5186-5193, 1996.
DOI : 10.1128/MCB.16.9.5186

P. Jeggo, G. Taccioli, and J. Sp, Ménage à trois: doublestrand break repair, V(D)J recombination and DNA-PK Bioessays, pp.949-957, 1995.

M. Fernet, V. Ponette, E. Deniaud-alexandre, J. Ménissier-de-murcia, G. De-murcia et al., Mégnin-Chanet F and Favaudon V: Poly(ADPribose ) polymerase, a major determinant of early cell response to ionising radiation, Int J Radiat Biol, vol.76, pp.1621-1629, 2000.

F. Dantzer, H. Nasheuer, J. Vonesch, G. De-murcia, M. Murcia et al., Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication, Nucleic Acids Research, vol.26, issue.8, pp.1891-1898, 1998.
DOI : 10.1093/nar/26.8.1891

M. Masson, C. Niedergang, V. Schreiber, S. Müller, J. Ménissier-de-murcia et al., XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage, Molecular and Cellular Biology, vol.18, issue.6, pp.3563-3571, 1998.
DOI : 10.1128/MCB.18.6.3563

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC108937

G. De-murcia and S. Shall, From DNA damage and stress signalling to cell death. Poly ADP-ribosylation reactions, 2000.

G. De-murcia, M. Murcia, and J. , Poly(ADP-ribose) polymerase: a molecular nick-sensor Trends Biochem Sci, pp.172-176, 1994.

J. Wesierska-gadek, A. Bugajska-schretter, and C. Cerni, ADP-ribosylation of p53 tumor suppressor protein: Mutant but not wild-type p53 is modified, Journal of Cellular Biochemistry, vol.13, issue.1, pp.90-101, 1996.
DOI : 10.1002/(SICI)1097-4644(199607)62:1<90::AID-JCB10>3.0.CO;2-J

J. Pleschke, H. Kleczkowska, M. Strohm, and A. Fr, Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins, Journal of Biological Chemistry, vol.275, issue.52, pp.40974-40980, 2000.
DOI : 10.1074/jbc.M006520200

C. Morrison, G. Smith, L. Stingl, S. Jackson, E. Wagner et al., Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis, Nature Genetics, vol.83, issue.4, pp.479-482, 1997.
DOI : 10.1038/ng1297-479

T. Ruscetti, B. Lehnert, J. Halbrook, L. Trong, H. Hoekstra et al., Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase, Journal of Biological Chemistry, vol.273, issue.23, pp.14461-14467, 1998.
DOI : 10.1074/jbc.273.23.14461

S. Galande and T. Kohwi-shigematsu, Poly(ADP-ribose) Polymerase and Ku Autoantigen Form a Complex and Synergistically Bind to Matrix Attachment Sequences, Journal of Biological Chemistry, vol.274, issue.29, pp.20521-20528, 1999.
DOI : 10.1074/jbc.274.29.20521

Y. Ariumi, M. Masutani, T. Copeland, T. Mimori, T. Sugimura et al., Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro Oncogene, pp.4616-4625, 1999.

Y. Ariumi, K. Ueda, M. Masutani, T. Copeland, M. Noda et al., In vivo phosphorylation of poly(ADPribose ) polymerase is independent of its activation FEBS Lett, pp.288-292, 1998.

M. Brown, D. Franco, A. Burkle, and Y. Chang, Role of poly(ADP-ribosyl)ation in DNA-PKcs- independent V(D)J recombination, Proceedings of the National Academy of Sciences, vol.105, issue.2, pp.4532-4537, 2002.
DOI : 10.1016/S0092-8674(01)00309-9

V. Favaudon, On the mechanism of reductive activation in the mode of action of some anticancer drugs, Biochimie, vol.64, issue.7, pp.457-475, 1982.
DOI : 10.1016/S0300-9084(82)80162-4

P. Dedon and I. Goldberg, Free-radical mechanisms involved in the formation of sequence-dependent bistranded DNA lesions by the antitumor antibiotics bleomycin, neocarzinostatin, and calicheamicin, Chemical Research in Toxicology, vol.5, issue.3, pp.311-332, 1992.
DOI : 10.1021/tx00027a001

L. Kappen and I. Goldberg, Deoxyribonucleic acid damage by neocarzinostatin chromophore: strand breaks generated by

M. Banasik, H. Komura, M. Shimoyama, and K. Ueda, Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl) transferase, J Biol Chem, vol.267, pp.1569-1575, 1992.

F. Bernges and W. Zeller, Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines ?with special reference to cisplatin, Journal of Cancer Research and Clinical Oncology, vol.72, issue.11, pp.665-670, 1996.
DOI : 10.1007/BF01209029

A. Schlicker, P. Peschke, A. Bürkle, E. Hahn, and J. Kim, 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer, International Journal of Radiation Biology, vol.75, issue.1, pp.91-100, 1999.
DOI : 10.1080/095530099140843

D. Blöcher, M. Einspenner, and J. Zajackowski, CHEF Electrophoresis, a Sensitive Technique for the Determination of DNA Double-strand Breaks, International Journal of Radiation Biology, vol.5, issue.4, pp.437-448, 1989.
DOI : 10.1080/07391102.1985.10508418

E. Woudstra, J. Roesink, M. Rosemann, J. Brunsting, C. Driessen et al., Chromatin structure and cellular radiosensitivity: a comparison of two human tumour cell lines, International Journal of Radiation Biology, vol.336, issue.141, pp.693-703, 1996.
DOI : 10.1080/095530096144581

M. Cornforth and J. Bedford, A Quantitative Comparison of Potentially Lethal Damage Repair and the Rejoining of Interphase Chromosome Breaks in Low Passage Normal Human Fibroblasts, Radiation Research, vol.111, issue.3, pp.385-405, 1987.
DOI : 10.2307/3576926