INTRODUCTION: It has been suggested that the elastic network plays an important role in the tissue response to mechanical stress. The components of the elastic network have been poorly studied in liver diseases. Therefore, in this work, the expression and distribution of fibrillin-1 and elastin were studied in hepatic focal nodular hyperplasia and compared with surrounding liver and hepatocellular adenoma. METHODS: Immunohistochemical studies for fibrillin-1 and elastin were performed on unfixed cryostat sections of focal nodular hyperplasia (22 cases), hepatocellular adenoma (15 cases) and surrounding liver (34 cases). RESULTS: Surrounding normal liver showed only a continuous, thin and regular immunostaining of fibrillin-1 in the space of Disse, whereas elastin was nearly absent. In focal nodular hyperplasia, fibrillin-1 was more strongly expressed in the perisinusoidal space, compared with surrounding liver; in contrast, in adenomas fibrillin-1 immunostaining was irregular and very low in perisinusoidal space, more intense in peliotic areas. CONCLUSIONS: In focal nodular hyperplasia, the increased microfibrillar network containing fibrillin-1 in the space of Disse could reflect an adaptation of the sinusoidal wall to an increased arterial blood flow in sinusoids. In hepatocellular adenoma, the different patterns of fibrillin-1 could be related to the heterogeneity of the arterial vascularization and to the frequent necrotico-hemorrhagic changes. This study comparing the elastic network in two types of lesions with vascularization abnormalities and in the surrounding liver provides interesting new data for understanding the structural role of fibrillin-1 in the space of Disse.