A. Roberts and M. Sporn, Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta) Growth Factors, pp.1-9, 1993.

A. Roberts and M. Sporn, Differential expression of the TGF-? isoforms in embryogenesis suggests specific roles in developing and adult tissues, Molecular Reproduction and Development, vol.108, issue.7, pp.91-98, 1992.
DOI : 10.1002/mrd.1080320203

B. Hogan, Bone morphogenetic proteins: multifunctional regulators of vertebrate development., Genes & Development, vol.10, issue.13, pp.1580-1594, 1996.
DOI : 10.1101/gad.10.13.1580

. Whitman, Smads and early developmental signaling by the TGFbeta superfamily, Genes & Development, vol.12, issue.16, pp.2445-2462, 1998.
DOI : 10.1101/gad.12.16.2445

J. Massague, TGF-?? SIGNAL TRANSDUCTION, Annual Review of Biochemistry, vol.67, issue.1, pp.753-791, 1998.
DOI : 10.1146/annurev.biochem.67.1.753

J. Wrana, L. Attisano, J. Carcamo, A. Zentella, J. Doody et al., TGF?? signals through a heteromeric protein kinase receptor complex, Cell, vol.71, issue.6, pp.1003-1014, 1992.
DOI : 10.1016/0092-8674(92)90395-S

J. Massague, J. Andres, L. Attisano, S. Cheifetz, F. Lopez-casillas et al., TGF-?? receptors, Molecular Reproduction and Development, vol.11, issue.2, pp.99-104, 1992.
DOI : 10.1002/mrd.1080320204

L. Attisano, J. Wrana, E. Montalvo, and J. Massague, Activation of signalling by the activin receptor complex., Molecular and Cellular Biology, vol.16, issue.3, pp.1066-1073, 1996.
DOI : 10.1128/MCB.16.3.1066

R. Wieser, J. Wrana, and J. Massague, GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex, EMBO J, vol.14, pp.2199-2208, 1995.

T. Wang, B. Li, P. Danielson, P. Shah, S. Rockwell et al., The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGF?? Family Type I Receptors, Cell, vol.86, issue.3, pp.435-444, 1996.
DOI : 10.1016/S0092-8674(00)80116-6

M. Huse, T. Muir, L. Xu, Y. Chen, J. Kuriyan et al., The TGF?? Receptor Activation Process, Molecular Cell, vol.8, issue.3, pp.671-682, 2001.
DOI : 10.1016/S1097-2765(01)00332-X

M. Huse, Y. Chen, J. Massague, and J. Kuriyan, Crystal Structure of the Cytoplasmic Domain of the Type I TGF ?? Receptor in Complex with FKBP12, Cell, vol.96, issue.3, pp.425-436, 1999.
DOI : 10.1016/S0092-8674(00)80555-3

L. Attisano and J. Wrana, Signal Transduction by the TGF-beta Superfamily, Science, vol.296, issue.5573, pp.1646-1647, 2002.
DOI : 10.1126/science.1071809

Y. Zhang and R. Derynck, Regulation of Smad signalling by protein associations and signalling crosstalk, Trends in Cell Biology, vol.9, issue.7, pp.274-279, 1999.
DOI : 10.1016/S0962-8924(99)01579-2

K. Miyazono, P. Ten-dijke, and C. Heldin, TGF-?? signaling by Smad proteins, Adv Immunol, vol.75, pp.115-157, 2000.
DOI : 10.1016/S0065-2776(00)75003-6

C. Heldin, K. Miyazono, and P. Ten-dijke, TGF-beta signalling from cell membrane to nucleus through SMAD proteins, Nature, vol.390, issue.6659, pp.465-471, 1997.
DOI : 10.1038/37284

X. Liu, A. Elia, S. Law, E. Golemis, J. Farley et al., A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1, The EMBO Journal, vol.19, issue.24, pp.6759-6769, 2000.
DOI : 10.1093/emboj/19.24.6759

S. Stroschein, S. Bonni, J. Wrana, and K. Luo, Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN, Genes Dev, vol.15, pp.2822-2836, 2001.

Y. Wan, X. Liu, and M. Kirschner, The Anaphase-Promoting Complex Mediates TGF-?? Signaling by Targeting SnoN for Destruction, Molecular Cell, vol.8, issue.5, pp.1027-1039, 2001.
DOI : 10.1016/S1097-2765(01)00382-3

S. Law, J. Estojak, B. Wang, T. Mysliwiec, G. Kruh et al., Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae., Molecular and Cellular Biology, vol.16, issue.7, pp.3327-3337, 1996.
DOI : 10.1128/MCB.16.7.3327

S. Law, O. Neill, G. Fashena, S. Einarson, M. Golemis et al., The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion Sites, Molecular and Cellular Biology, vol.20, issue.14, pp.5184-5195, 2000.
DOI : 10.1128/MCB.20.14.5184-5195.2000

S. Law, Y. Zhang, A. Klein-szanto, and E. Golemis, Cell Cycle-Regulated Processing of HEF1 to Multiple Protein Forms Differentially Targeted to Multiple Subcellular Compartments, Molecular and Cellular Biology, vol.18, issue.6, pp.3540-3551, 1998.
DOI : 10.1128/MCB.18.6.3540

M. Minegishi, K. Tachibana, T. Sato, S. Iwata, Y. Nojima et al., Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes, Journal of Experimental Medicine, vol.184, issue.4, pp.1365-1375, 1996.
DOI : 10.1084/jem.184.4.1365

S. Manie, A. Beck, A. Astier, S. Law, T. Canty et al., Involvement of p130Cas and p105HEF1, a Novel Cas-like Docking Protein, in a Cytoskeleton-dependent Signaling Pathway Initiated by Ligation of Integrin or Antigen Receptor on Human B Cells, Journal of Biological Chemistry, vol.272, issue.7, pp.4230-4236, 1997.
DOI : 10.1074/jbc.272.7.4230

Y. Ohashi, K. Tachibana, K. Kamiguchi, H. Fujita, and C. Morimoto, T Cell Receptor-mediated Tyrosine Phosphorylation of Cas-L, a 105-kDa Crk-associated Substrate-related Protein, and Its Association of Crk and C3G, Journal of Biological Chemistry, vol.273, issue.11, pp.6446-6451, 1998.
DOI : 10.1074/jbc.273.11.6446

Z. Zhang, L. Hernandez-lagunas, W. Horne, and R. Baron, Cytoskeleton-dependent Tyrosine Phosphorylation of the p130Cas Family Member HEF1 Downstream of the G Protein-coupled Calcitonin Receptor: CALCITONIN INDUCES THE ASSOCIATION OF HEF1, PAXILLIN, AND FOCAL ADHESION KINASE, Journal of Biological Chemistry, vol.274, issue.35, pp.25093-25098, 1999.
DOI : 10.1074/jbc.274.35.25093

A. Hershko and A. Ciechanover, THE UBIQUITIN SYSTEM, Annual Review of Biochemistry, vol.67, issue.1, pp.425-479, 1998.
DOI : 10.1146/annurev.biochem.67.1.425

M. Glickman and A. Ciechanover, The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction, Physiological Reviews, vol.82, issue.2, pp.373-428, 2002.
DOI : 10.1152/physrev.00027.2001

G. Fang, H. Yu, and M. Kirschner, Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1, Molecular Cell, vol.2, issue.2, pp.163-171, 1998.
DOI : 10.1016/S1097-2765(00)80126-4

C. Pfleger and M. Kirschner, The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1, Genes Dev, vol.14, pp.655-665, 2000.

R. Grossberger, C. Gieffers, W. Zachariae, A. Podtelejnikov, A. Schleiffer et al., Characterization of the DOC1/APC10 Subunit of the Yeast and the Human Anaphase-promoting Complex, Journal of Biological Chemistry, vol.274, issue.20, pp.14500-14507, 1999.
DOI : 10.1074/jbc.274.20.14500

K. Wendt, H. Vodermaier, U. Jacob, C. Gieffers, M. Gmachl et al., Crystal structure of the APC10/ DOC1 subunit of the human anaphase-promoting complex, Nature Structural Biology, vol.8, issue.9, pp.784-788, 2001.
DOI : 10.1038/nsb0901-784

D. Pravtcheva and T. Wise, Disruption of Apc10/Doc1 in Three Alleles of Oligosyndactylism, Genomics, vol.72, issue.1, pp.78-87, 2001.
DOI : 10.1006/geno.2001.6474

S. Au, X. Leng, J. Harper, and D. Barford, Implications for the Ubiquitination Reaction of the Anaphase-promoting Complex from the Crystal Structure of the Doc1/Apc10 Subunit, Journal of Molecular Biology, vol.316, issue.4, pp.955-968, 2002.
DOI : 10.1006/jmbi.2002.5399

M. Schwab, A. Lutum, and W. Seufert, Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis, Cell, vol.90, issue.4, pp.683-693, 1997.
DOI : 10.1016/S0092-8674(00)80529-2

R. Visintin, S. Prinz, and A. Amon, CDC20 and CDH1: A Family of Substrate-Specific Activators of APC-Dependent Proteolysis, Science, vol.278, issue.5337, pp.460-463, 1997.
DOI : 10.1126/science.278.5337.460

C. Pfleger, E. Lee, and M. Kirschner, Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex, Genes & Development, vol.15, issue.18, pp.2396-2407, 2001.
DOI : 10.1101/gad.918201

T. Tsukazaki, T. Chiang, A. Davison, L. Attisano, and J. Wrana, SARA, a FYVE Domain Protein that Recruits Smad2 to the TGF?? Receptor, Cell, vol.95, issue.6, pp.779-791, 1998.
DOI : 10.1016/S0092-8674(00)81701-8

B. Qin, S. Lam, J. Correia, and K. Lin, Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control, Genes & Development, vol.16, issue.15, pp.1950-1963, 2002.
DOI : 10.1101/gad.1002002

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC186427

A. Moustakas and C. Heldin, From mono- to oligo-Smads: The heart of the matter in TGF-beta signal transduction, Genes & Development, vol.16, issue.15, pp.1867-1871, 2002.
DOI : 10.1101/gad.1016802

X. Liu, Y. Sun, R. Weinberg, and H. Lodish, Ski/Sno and TGF-?? signaling, Cytokine & Growth Factor Reviews, vol.12, issue.1, pp.1-8, 2001.
DOI : 10.1016/S1359-6101(00)00031-9