Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta) Growth Factors, pp.1-9, 1993. ,
Differential expression of the TGF-? isoforms in embryogenesis suggests specific roles in developing and adult tissues, Molecular Reproduction and Development, vol.108, issue.7, pp.91-98, 1992. ,
DOI : 10.1002/mrd.1080320203
Bone morphogenetic proteins: multifunctional regulators of vertebrate development., Genes & Development, vol.10, issue.13, pp.1580-1594, 1996. ,
DOI : 10.1101/gad.10.13.1580
Smads and early developmental signaling by the TGFbeta superfamily, Genes & Development, vol.12, issue.16, pp.2445-2462, 1998. ,
DOI : 10.1101/gad.12.16.2445
TGF-?? SIGNAL TRANSDUCTION, Annual Review of Biochemistry, vol.67, issue.1, pp.753-791, 1998. ,
DOI : 10.1146/annurev.biochem.67.1.753
TGF?? signals through a heteromeric protein kinase receptor complex, Cell, vol.71, issue.6, pp.1003-1014, 1992. ,
DOI : 10.1016/0092-8674(92)90395-S
TGF-?? receptors, Molecular Reproduction and Development, vol.11, issue.2, pp.99-104, 1992. ,
DOI : 10.1002/mrd.1080320204
Activation of signalling by the activin receptor complex., Molecular and Cellular Biology, vol.16, issue.3, pp.1066-1073, 1996. ,
DOI : 10.1128/MCB.16.3.1066
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex, EMBO J, vol.14, pp.2199-2208, 1995. ,
The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGF?? Family Type I Receptors, Cell, vol.86, issue.3, pp.435-444, 1996. ,
DOI : 10.1016/S0092-8674(00)80116-6
The TGF?? Receptor Activation Process, Molecular Cell, vol.8, issue.3, pp.671-682, 2001. ,
DOI : 10.1016/S1097-2765(01)00332-X
Crystal Structure of the Cytoplasmic Domain of the Type I TGF ?? Receptor in Complex with FKBP12, Cell, vol.96, issue.3, pp.425-436, 1999. ,
DOI : 10.1016/S0092-8674(00)80555-3
Signal Transduction by the TGF-beta Superfamily, Science, vol.296, issue.5573, pp.1646-1647, 2002. ,
DOI : 10.1126/science.1071809
Regulation of Smad signalling by protein associations and signalling crosstalk, Trends in Cell Biology, vol.9, issue.7, pp.274-279, 1999. ,
DOI : 10.1016/S0962-8924(99)01579-2
TGF-?? signaling by Smad proteins, Adv Immunol, vol.75, pp.115-157, 2000. ,
DOI : 10.1016/S0065-2776(00)75003-6
TGF-beta signalling from cell membrane to nucleus through SMAD proteins, Nature, vol.390, issue.6659, pp.465-471, 1997. ,
DOI : 10.1038/37284
A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1, The EMBO Journal, vol.19, issue.24, pp.6759-6769, 2000. ,
DOI : 10.1093/emboj/19.24.6759
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN, Genes Dev, vol.15, pp.2822-2836, 2001. ,
The Anaphase-Promoting Complex Mediates TGF-?? Signaling by Targeting SnoN for Destruction, Molecular Cell, vol.8, issue.5, pp.1027-1039, 2001. ,
DOI : 10.1016/S1097-2765(01)00382-3
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae., Molecular and Cellular Biology, vol.16, issue.7, pp.3327-3337, 1996. ,
DOI : 10.1128/MCB.16.7.3327
The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion Sites, Molecular and Cellular Biology, vol.20, issue.14, pp.5184-5195, 2000. ,
DOI : 10.1128/MCB.20.14.5184-5195.2000
Cell Cycle-Regulated Processing of HEF1 to Multiple Protein Forms Differentially Targeted to Multiple Subcellular Compartments, Molecular and Cellular Biology, vol.18, issue.6, pp.3540-3551, 1998. ,
DOI : 10.1128/MCB.18.6.3540
Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes, Journal of Experimental Medicine, vol.184, issue.4, pp.1365-1375, 1996. ,
DOI : 10.1084/jem.184.4.1365
Involvement of p130Cas and p105HEF1, a Novel Cas-like Docking Protein, in a Cytoskeleton-dependent Signaling Pathway Initiated by Ligation of Integrin or Antigen Receptor on Human B Cells, Journal of Biological Chemistry, vol.272, issue.7, pp.4230-4236, 1997. ,
DOI : 10.1074/jbc.272.7.4230
T Cell Receptor-mediated Tyrosine Phosphorylation of Cas-L, a 105-kDa Crk-associated Substrate-related Protein, and Its Association of Crk and C3G, Journal of Biological Chemistry, vol.273, issue.11, pp.6446-6451, 1998. ,
DOI : 10.1074/jbc.273.11.6446
Cytoskeleton-dependent Tyrosine Phosphorylation of the p130Cas Family Member HEF1 Downstream of the G Protein-coupled Calcitonin Receptor: CALCITONIN INDUCES THE ASSOCIATION OF HEF1, PAXILLIN, AND FOCAL ADHESION KINASE, Journal of Biological Chemistry, vol.274, issue.35, pp.25093-25098, 1999. ,
DOI : 10.1074/jbc.274.35.25093
THE UBIQUITIN SYSTEM, Annual Review of Biochemistry, vol.67, issue.1, pp.425-479, 1998. ,
DOI : 10.1146/annurev.biochem.67.1.425
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction, Physiological Reviews, vol.82, issue.2, pp.373-428, 2002. ,
DOI : 10.1152/physrev.00027.2001
Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1, Molecular Cell, vol.2, issue.2, pp.163-171, 1998. ,
DOI : 10.1016/S1097-2765(00)80126-4
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1, Genes Dev, vol.14, pp.655-665, 2000. ,
Characterization of the DOC1/APC10 Subunit of the Yeast and the Human Anaphase-promoting Complex, Journal of Biological Chemistry, vol.274, issue.20, pp.14500-14507, 1999. ,
DOI : 10.1074/jbc.274.20.14500
Crystal structure of the APC10/ DOC1 subunit of the human anaphase-promoting complex, Nature Structural Biology, vol.8, issue.9, pp.784-788, 2001. ,
DOI : 10.1038/nsb0901-784
Disruption of Apc10/Doc1 in Three Alleles of Oligosyndactylism, Genomics, vol.72, issue.1, pp.78-87, 2001. ,
DOI : 10.1006/geno.2001.6474
Implications for the Ubiquitination Reaction of the Anaphase-promoting Complex from the Crystal Structure of the Doc1/Apc10 Subunit, Journal of Molecular Biology, vol.316, issue.4, pp.955-968, 2002. ,
DOI : 10.1006/jmbi.2002.5399
Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis, Cell, vol.90, issue.4, pp.683-693, 1997. ,
DOI : 10.1016/S0092-8674(00)80529-2
CDC20 and CDH1: A Family of Substrate-Specific Activators of APC-Dependent Proteolysis, Science, vol.278, issue.5337, pp.460-463, 1997. ,
DOI : 10.1126/science.278.5337.460
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex, Genes & Development, vol.15, issue.18, pp.2396-2407, 2001. ,
DOI : 10.1101/gad.918201
SARA, a FYVE Domain Protein that Recruits Smad2 to the TGF?? Receptor, Cell, vol.95, issue.6, pp.779-791, 1998. ,
DOI : 10.1016/S0092-8674(00)81701-8
Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control, Genes & Development, vol.16, issue.15, pp.1950-1963, 2002. ,
DOI : 10.1101/gad.1002002
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC186427
From mono- to oligo-Smads: The heart of the matter in TGF-beta signal transduction, Genes & Development, vol.16, issue.15, pp.1867-1871, 2002. ,
DOI : 10.1101/gad.1016802
Ski/Sno and TGF-?? signaling, Cytokine & Growth Factor Reviews, vol.12, issue.1, pp.1-8, 2001. ,
DOI : 10.1016/S1359-6101(00)00031-9