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Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development.

Abstract : BACKGROUND: Poly (ADP-ribosyl)ation is a covalent modification of many nuclear proteins. It has a strong chromatin modifying potential involved in DNA repair, transcription and replication. Its role during preimplantation development is unknown. RESULTS: We have observed strong but transient synthesis of poly ADP-ribose polymers on decondensing chromosomes of fertilized and parthenogenetically activated mouse oocytes. Inhibition of this transient upregulation with a specific enzyme inhibitor, 3-aminobenzamide, has long-term effects on the postimplantation development of the embryos. In addition, inhibition of poly (ADP-ribosyl)ation at the 4-8 cell stage selectively blocks morula compaction. CONCLUSION: These observations suggest that poly (ADP-ribosyl)ation is involved in the epigenetic chromatin remodeling in the zygote.
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Takuya Imamura, Thi My Anh Neildez, Catherine Thenevin, Andras Paldi. Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development.. BMC Molecular Biology, BioMed Central, 2004, 5, pp.4. ⟨10.1186/1471-2199-5-4⟩. ⟨inserm-00112018⟩



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