P. Pintavorn and B. Ballermann, TGF-?? and the endothelium during immune injury, Kidney International, vol.51, issue.5, pp.1401-1412, 1997.
DOI : 10.1038/ki.1997.192

S. Wahl, J. Allen, G. Costa, H. Wong, and J. Dasch, Reversal of acute and chronic synovial inflammation by anti- transforming growth factor beta, Journal of Experimental Medicine, vol.177, issue.1, pp.225-230, 1993.
DOI : 10.1084/jem.177.1.225

T. Wyss-coray, L. Feng, E. Masliah, M. Ruppe, H. Lee et al., Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1, Am J Pathol, vol.147, pp.53-67, 1995.

T. Wyss-coray, C. Lin, D. Sanan, L. Mucke, and E. Masliah, Chronic Overproduction of Transforming Growth Factor-??1 by Astrocytes Promotes Alzheimer's Disease-Like Microvascular Degeneration in Transgenic Mice, The American Journal of Pathology, vol.156, issue.1, pp.139-50, 2000.
DOI : 10.1016/S0002-9440(10)64713-X

T. Wyss-coray, C. Lin, D. Von-euw, E. Masliah, L. Mucke et al., Alzheimer's Disease-like Cerebrovascular Pathology in Transforming Growth Factor-beta1 Transgenic Mice and Functional Metabolic Correlates, Annals of the New York Academy of Sciences, vol.156, issue.1 VASCULAR FACT, pp.317-323, 2000.
DOI : 10.1002/(SICI)1098-1136(199805)23:1<1::AID-GLIA1>3.3.CO;2-Q

T. Wyss-coray, E. Masliah, M. Mallory, L. Mcconlogue, K. Johnson-wood et al., Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease, Nature, vol.389, issue.6651, pp.603-606, 1997.
DOI : 10.1038/39321

T. Wyss-coray, C. Lin, F. Yan, G. Yu, M. Rohde et al., TGF-beta1 promotes microglial amyloidbeta clearance and reduces plaque burden in transgenic mice, Nature Medicine, vol.7, issue.5, pp.612-618, 2001.
DOI : 10.1038/87945

A. Snow, R. Sekiguchi, D. Nochlin, P. Fraser, K. Kimata et al., An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar a??-amyloid in rat brain, Neuron, vol.12, issue.1, pp.219-234, 1994.
DOI : 10.1016/0896-6273(94)90165-1

H. Vinters, Z. Wang, and D. Secor, Brain Parenchymal and Microvascular Amyloid in Alzheimer's Disease, Brain Pathology, vol.49, issue.2, pp.179-195, 1996.
DOI : 10.1002/ana.410370303

R. Kalaria, Cerebrovascular Degeneration Is Related to Amyloid-? Protein Deposition in Alzheimer's Disease, Annals of the New York Academy of Sciences, vol.18, issue.1 Cerebrovascul, pp.263-271, 1997.
DOI : 10.1038/380168a0

S. Greenberg, Cerebral Amyloid Angiopathy and Vessel Dysfunction, Cerebrovascular Diseases, vol.13, issue.2, pp.42-47, 2002.
DOI : 10.1159/000049149

L. Pfeifer, L. White, G. Ross, H. Petrovitch, and L. Launer, Cerebral amyloid angiopathy and cognitive function: The HAAS autopsy study, Neurology, vol.58, issue.11, pp.1629-1634, 2002.
DOI : 10.1212/WNL.58.11.1629

P. Mcgeer and E. Mcgeer, Local Neuroinflammation and the Progression of Alzheimer's Disease, Journal of Neurovirology, vol.8, issue.6, pp.529-538, 2002.
DOI : 10.1080/13550280290100969

B. Veld, A. Ruitenberg, A. Hofman, L. Launer, C. Van-duijn et al., Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease, New England Journal of Medicine, vol.345, issue.21, pp.1515-1521, 2001.
DOI : 10.1056/NEJMoa010178

G. Lim, F. Yang, T. Chu, P. Chen, W. Beech et al., Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease, J Neurosci, vol.20, pp.5709-5714, 2000.

G. Lim, F. Yang, T. Chu, E. Gahtan, O. Ubeda et al., Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice, Neurobiology of Aging, vol.22, issue.6, pp.983-991, 2001.
DOI : 10.1016/S0197-4580(01)00299-8

M. Ricote, J. Huang, J. Welch, and C. Glass, The peroxisome proliferator-activated receptor (PPARgamma) as a regulator of monocyte/macrophage function, J Leukoc Biol, vol.66, pp.733-739, 1999.

M. Heneka, T. Klockgether, and D. Feinstein, Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo, J Neurosci, vol.20, pp.6862-6867, 2000.

C. Combs, D. Johnson, J. Karlo, S. Cannady, and G. Landreth, Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists, J Neurosci, vol.20, pp.558-567, 2000.

D. Feinstein, E. Galea, V. Gavrilyuk, C. Brosnan, C. Whitacre et al., Peroxisome proliferator-activated receptor-? agonists prevent experimental autoimmune encephalomyelitis, Annals of Neurology, vol.168, issue.6, pp.694-702, 2002.
DOI : 10.1002/ana.10206

T. Breidert, J. Callebert, M. Heneka, G. Landreth, J. Launay et al., Protective action of the peroxisome proliferator-activated receptor-?? agonist pioglitazone in a mouse model of Parkinson's disease, Journal of Neurochemistry, vol.178, issue.18, pp.615-624, 2002.
DOI : 10.1046/j.1471-4159.2002.00990.x

E. Galea and D. Feinstein, Probing PPARg agonists: could diabetes drugs treat Alzheimer's disease? Alzheimer Research Forum, 2002.

D. Games, D. Adams, R. Alessandrini, R. Barbour, P. Berthelette et al., Alzheimer-type neuropathology in transgenic mice overexpressing V717F ??-amyloid precursor protein, Nature, vol.373, issue.6514, pp.523-527, 1995.
DOI : 10.1038/373523a0

P. Mathews, Y. Jiang, S. Schmidt, O. Grbovic, M. Mercken et al., Calpain Activity Regulates the Cell Surface Distribution of Amyloid Precursor Protein: INHIBITION OF CALPAINS ENHANCES ENDOSOMAL GENERATION OF ??-CLEAVED C-TERMINAL APP FRAGMENTS, Journal of Biological Chemistry, vol.277, issue.39, pp.36415-36439, 2002.
DOI : 10.1074/jbc.M205208200

R. Rozmahel, J. Huang, F. Chen, Y. Liang, V. Nguyen et al., Normal brain development in PS1 hypomorphic mice with markedly reduced ??-secretase cleavage of ??APP, Neurobiology of Aging, vol.23, issue.2, pp.187-94, 2002.
DOI : 10.1016/S0197-4580(01)00267-6

R. Rozmahel, H. Mount, F. Chen, V. Nguyen, J. Huang et al., Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype, Proceedings of the National Academy of Sciences, vol.70, issue.6, pp.14452-14459, 2002.
DOI : 10.1086/340732

H. Xu, G. Gouras, J. Greenfield, B. Vincent, J. Naslund et al., Estrogen reduces neuronal generation of Alzheimer ??-amyloid peptides, Nature Medicine, vol.240, issue.4, pp.447-51, 1998.
DOI : 10.1016/0092-8674(89)90177-3

M. Armogida, A. Petit, B. Vincent, S. Scarzello, C. Da-costa et al., Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts, Nature Cell Biology, vol.3, issue.11, pp.1030-1033, 2001.
DOI : 10.1038/ncb1101-1030

K. Kim, Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide, Neuroscience Research Communications, vol.2, pp.121-130, 1988.

M. Pepys, Pathogenesis, diagnosis and treatment of systemic amyloidosis, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.356, issue.1406, pp.203-211, 2001.
DOI : 10.1098/rstb.2000.0766

T. Wyss-coray, P. Borrow, M. Brooker, and L. Mucke, Astroglial overproduction of TGF-??1 enhances inflammatory central nervous system disease in transgenic mice, Journal of Neuroimmunology, vol.77, issue.1, pp.45-50, 1997.
DOI : 10.1016/S0165-5728(97)00049-0

G. Munch, J. Gasic-milenkovic, S. Dukic-stefanovic, B. Kuhla, K. Heinrich et al., Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction of differentiated neuroblastoma cells, Experimental Brain Research, vol.920, issue.1, pp.1-8, 2003.
DOI : 10.1016/S0006-8993(01)02872-4

F. Sabri, K. Titanji, D. Milito, A. Chiodi, and F. , Astrocyte Activation and Apoptosis: Their Roles in the Neuropathology of HIV Infection, Brain Pathology, vol.98, issue.1, pp.84-94, 2003.
DOI : 10.1111/j.1750-3639.2003.tb00009.x

J. Nitta and T. Tada, Ultramicroscopic Structures of the Leptomeninx of Mice with Communicating Hydrocephalus Induced by Human Recombinant Transforming Growth Factor-??1, Neurologia medico-chirurgica, vol.38, issue.12, pp.819-824, 1998.
DOI : 10.2176/nmc.38.819

S. Moinuddin and T. Tada, Study of cerebrospinal fluid flow dynamics in TGF-??1 induced chronic hydrocephalic mice, Neurological Research, vol.22, issue.2, pp.215-222, 2000.
DOI : 10.1080/01616412.2000.11741064

C. Johanson, J. Szmydynger-chodobska, A. Chodobski, A. Baird, P. Mcmillan et al., Altered formation and bulk absorption of cerebrospinal fluid in FGF-2-induced hydrocephalus, Am J Physiol, vol.277, pp.263-271, 1999.

M. Pawlik, E. Fuchs, L. Walker, and E. Levy, Primate-like amyloid-?? sequence but no cerebral amyloidosis in aged tree shrews, Neurobiology of Aging, vol.20, issue.1, pp.47-51, 1999.
DOI : 10.1016/S0197-4580(99)00017-2

S. Lesne, F. Docagne, C. Gabriel, G. Liot, D. Lahiri et al., Transforming Growth Factor-??1 Potentiates Amyloid-?? Generation in Astrocytes and in Transgenic Mice, Journal of Biological Chemistry, vol.278, issue.20, pp.18408-18426, 2003.
DOI : 10.1074/jbc.M300819200

T. Burton, B. Liang, A. Dibrov, and F. Amara, Transcriptional activation and increase in expression of Alzheimer's ??-amyloid precursor protein gene is mediated by TGF-?? in normal human astrocytes, Biochemical and Biophysical Research Communications, vol.295, issue.3, pp.702-712, 2002.
DOI : 10.1016/S0006-291X(02)00724-6

J. Sipe and A. Cohen, Review: History of the Amyloid Fibril, Journal of Structural Biology, vol.130, issue.2-3, pp.88-98, 2000.
DOI : 10.1006/jsbi.2000.4221

T. Revesz, J. Holton, T. Lashley, G. Plant, A. Rostagno et al., Sporadic and Familial Cerebral Amyloid Angiopathies, Brain Pathology, vol.93, issue.Suppl 43, pp.343-57, 2002.
DOI : 10.1111/j.1750-3639.2002.tb00449.x

S. Preston, P. Steart, A. Wilkinson, J. Nicoll, and R. Weller, Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid????? from the human brain, Neuropathology and Applied Neurobiology, vol.83, issue.2, pp.106-117, 2003.
DOI : 10.1046/j.1365-2990.2003.00424.x

R. Weller and J. Nicoll, Cerebral amyloid angiopathy: Pathogenesis and effects on the ageing and Alzheimer brain, Neurological Research, vol.9, issue.1619, pp.611-616, 2003.
DOI : 10.1126/science.1078259

T. Wyss-coray, C. Lin, D. Sanan, L. Mucke, and E. Masliah, Chronic Overproduction of Transforming Growth Factor-??1 by Astrocytes Promotes Alzheimer's Disease-Like Microvascular Degeneration in Transgenic Mice, The American Journal of Pathology, vol.156, issue.1, pp.139-150, 2000.
DOI : 10.1016/S0002-9440(10)64713-X

S. Kumar-singh, P. Cras, R. Wang, J. Kros, J. Van-swieten et al., Dense-Core Senile Plaques in the Flemish Variant of Alzheimer's Disease Are Vasocentric, The American Journal of Pathology, vol.161, issue.2, pp.507-527, 2002.
DOI : 10.1016/S0002-9440(10)64207-1

M. Botto, P. Hawkins, M. Bickerstaff, J. Herbert, A. Bygrave et al., Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene, Nature Medicine, vol.37, issue.8, pp.855-864, 1997.
DOI : 10.1038/378779a0

R. Veerhuis, M. Van-breemen, J. Hoozemans, M. Morbin, J. Ouladhadj et al., Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta1-42 peptideinduced cytokine secretion by adult human microglia in vitro, Acta Neuropathol, vol.105, pp.135-179, 2003.

J. Shi, G. Perry, G. Aliev, M. Smith, K. Ashe et al., Serum amyloid P is not present in amyloid ?? deposits of a transgenic animal modela, NeuroReport, vol.10, issue.15, pp.3229-3261, 1999.
DOI : 10.1097/00001756-199910190-00019

N. Abbot, Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology, Neurochemistry International, vol.45, issue.4, pp.2010-2031, 1992.
DOI : 10.1016/j.neuint.2003.11.006

C. Mclean, R. Cherny, F. Fraser, S. Fuller, M. Smith et al., Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease, Annals of Neurology, vol.155, issue.6, pp.860-866, 1999.
DOI : 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M

J. Van-dorpe, L. Smeijers, I. Dewachter, D. Nuyens, K. Spittaels et al., Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons, The American Journal of Pathology, vol.157, issue.4, pp.1283-1298, 2000.
DOI : 10.1016/S0002-9440(10)64644-5