Skip to Main content Skip to Navigation
Journal articles

Synthesis and structural studies of a novel scaffold for drug discovery: a 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

Abstract : We describe the three-step synthesis of a novel 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] scaffold from ortho-hydroxyacetophenone and N-benzylpiperidone. The structure of one disubstituted derivative, studied by NOESY NMR in an aqueous medium and X-ray diffraction, demonstrates that this scaffold presents side chains in a well-defined orientation. The Boc protected derivative represents a key intermediate for the combinatorial synthesis of drug-like molecules.
Document type :
Journal articles
Complete list of metadata

Cited literature [4 references]  Display  Hide  Download
Contributor : Nicolas Willand <>
Submitted on : Monday, October 30, 2006 - 8:29:55 AM
Last modification on : Thursday, January 7, 2021 - 4:46:02 PM
Long-term archiving on: : Friday, November 25, 2016 - 1:20:58 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Nicolas Willand, Terence Beghyn, Guy Nowogrocki, Jean-Claude Gesquiere, Benoit Deprez. Synthesis and structural studies of a novel scaffold for drug discovery: a 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]. Tetrahedron Letters, Elsevier, 2004, 45, pp.1051-1054. ⟨10.1016/j.tetlet.2003.11.079⟩. ⟨inserm-00110444⟩



Record views