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A simple reaction to produce small structurally complex and diverse molecules

Abstract : In order to mimic the complexity of natural products, we designed and obtained with simple synthetic methods, building blocks with 'quaternary chiral centers'. These tricyclic lactams resulted from the reaction of a functional [gamma]-keto-acid and various commercially available bi-nucleophiles. We describe the stereoselective synthesis of tricyclic lactams containing a chiral quaternary center and suitable for the synthesis of chemical libraries in order to mimic the complexity of natural compounds.
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Submitted on : Monday, October 30, 2006 - 8:25:15 AM
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Rebecca Deprez-Poulain, Nicolas Willand, Christophe Boutillon, Guy Nowogrocki, Nathalie Azaroual, et al.. A simple reaction to produce small structurally complex and diverse molecules. Tetrahedron Letters, Elsevier, 2004, 45 (27), pp.5287-5290. ⟨10.1016/j.tetlet.2004.05.008⟩. ⟨inserm-00110443⟩

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