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Solid and solution phase syntheses of the 2-cyanopyrrolidide DPP-IV inhibitor NVP-DPP728

Abstract : DPP-IV inhibitors have been suggested as potential new treatments for type-II diabetes and 2-cyanopyrrolidides have been reported as potent DPP-IV inhibitors. Alternative synthetic approaches to one such compound, NVP-DPP728, are investigated here. One strategy is based in solution phase and is amenable to scale-up. The other is based on solid phase and is appropriate for the rapid analoging of the structural series.
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https://www.hal.inserm.fr/inserm-00110441
Contributor : Nicolas Willand <>
Submitted on : Monday, October 30, 2006 - 8:19:56 AM
Last modification on : Wednesday, September 18, 2019 - 3:25:02 PM
Long-term archiving on: : Friday, November 25, 2016 - 1:26:27 PM

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Nicolas Willand, Jurgen Joossens, Jean-Claude Gesquière, André Tartar, D. Michael Evans, et al.. Solid and solution phase syntheses of the 2-cyanopyrrolidide DPP-IV inhibitor NVP-DPP728. Tetrahedron, Elsevier, 2002, 58, pp.5741-5746. ⟨10.1016/S0040-4020(02)00536-7⟩. ⟨inserm-00110441⟩

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