Abstract : We describe an efficient protocol for the Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. The optimised conditions were achieved using [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) as catalyst and Na2CO3 as base. A panel of structurally diverse arylboronic acids was used to demonstrate the scope of the coupling procedure. Keywords: ortho-Biphenyltetrazole; Suzuki-Miyaura cross-coupling; Microwave synthesis
https://www.hal.inserm.fr/inserm-00110439
Contributor : Nicolas Willand <>
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