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Efficient, protection-free Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles

Abstract : We describe an efficient protocol for the Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. The optimised conditions were achieved using [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) as catalyst and Na2CO3 as base. A panel of structurally diverse arylboronic acids was used to demonstrate the scope of the coupling procedure. Keywords: ortho-Biphenyltetrazole; Suzuki-Miyaura cross-coupling; Microwave synthesis
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Submitted on : Monday, October 30, 2006 - 12:21:56 AM
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Nicolas Cousaert, Patrick Toto, Nicolas Willand, Benoit Déprez. Efficient, protection-free Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles. Tetrahedron Letters, Elsevier, 2005, 46, pp.6529-6532. ⟨10.1016/j.tetlet.2005.07.082⟩. ⟨inserm-00110439⟩



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