Skip to Main content Skip to Navigation
Journal articles

Efficient, protection-free Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles

Nicolas Cousaert 1, 2 Patrick Toto 1, 2 Nicolas Willand 1, 2, * Benoit Déprez 1, 2
* Corresponding author
1 Biostructures et Decouverte de Medicament
2 SSFB - Synthèse, structure et fonction des biomolécules
Abstract : We describe an efficient protocol for the Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. The optimised conditions were achieved using [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) as catalyst and Na2CO3 as base. A panel of structurally diverse arylboronic acids was used to demonstrate the scope of the coupling procedure. Keywords: ortho-Biphenyltetrazole; Suzuki-Miyaura cross-coupling; Microwave synthesis
Keywords : ortho-Biphenyltetrazole Microwave synthesis Suzuki-Miyaura cross-coupling
Document type :
Journal articles
Complete list of metadatas

Cited literature [17 references]  Display  Hide  Download
https://www.hal.inserm.fr/inserm-00110439
Contributor : Nicolas Willand <>
Submitted on : Monday, October 30, 2006 - 12:21:56 AM
Last modification on : Wednesday, September 11, 2019 - 2:46:02 PM
Long-term archiving on: : Friday, November 25, 2016 - 1:44:01 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

CNRS | RIIP_LILLE | RIIP

Citation

Nicolas Cousaert, Patrick Toto, Nicolas Willand, Benoit Déprez. Efficient, protection-free Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles. Tetrahedron Letters, Elsevier, 2005, 46, pp.6529-6532. ⟨10.1016/j.tetlet.2005.07.082⟩. ⟨inserm-00110439⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

229