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LPA as a paracrine mediator of adipocyte growth and function.

Abstract : Adipogenesis corresponds to the recruitment of new adipocytes in adipose tissue, and results from the proliferation/differentiation of preadipocytes. Production of paracrine and autocrine factors by adipocytes plays an important role in adipogenesis. We recently demonstrated the existence of adipocyte production of lysophosphatidic acid (LPA) both in vitro and in situ. This production is modulated by catecholamines via alpha 2-adrenergic receptors. Adipocyte-LPA present in conditioned media increases the growth of a preadipose cell line in culture. This growth is associated with an activation of mitogen-activated protein kinases, and of the focal adhesion kinase. Because of the close proximity of preadipocytes and adipocytes within adipose tissue, adipocyte-LPA could play an important role in autocrine/paracrine control of adipogenesis.
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Contributor : Jean Sébastien Saulnier-Blache Connect in order to contact the contributor
Submitted on : Monday, January 8, 2007 - 3:34:20 PM
Last modification on : Thursday, August 4, 2022 - 5:25:51 PM
Long-term archiving on: : Tuesday, April 6, 2010 - 6:48:19 PM


  • HAL Id : inserm-00110167, version 1
  • PUBMED : 10818451


Céline Pagès, Alexia Girard, Olivier Jeanneton, Pierre Barbe, Claude Wolf, et al.. LPA as a paracrine mediator of adipocyte growth and function.. Annals of the New York Academy of Sciences, Wiley, 2000, 905, pp.159-64. ⟨inserm-00110167⟩



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