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Lysophosphatidic acid synthesis and release.

Abstract : Lysophosphatidic acid (LPA) is a bioactive phospholipid controlling numerous cellular responses through the activation of specific G-protein coupled transmembrane receptors. LPA is present in several biological fluids (serum, plasma, aqueous humor) and can be secreted by several cell types (platelets, fibroblasts, adipocytes, cancer cells). Whereas, multiple pathways of synthesis and degradation of LPA have been described, their relative contribution in extracellular secretion and biodisponibility is still a matter of debate. The first part of the present review is devoted to the description of the different enzymes involved in LPA synthesis (acyltransferases, phospholipases, kinases) and degradation (lysophospholipases, lipid-phosphatases), as well as to the molecules involved in LPA transport (albumin, fatty acid binding proteins, gelsolin, lipoproteins). In a second part, the different physio-pathological situations (aggregation, cancer, injuries) associated with LPA production, as well as the potential role played by LPA in genesis of certain diseases (cancer, obesity, arteriosclerosis) are listed and analyzed.
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Contributor : Jean Sébastien Saulnier-Blache Connect in order to contact the contributor
Submitted on : Friday, October 27, 2006 - 8:29:01 AM
Last modification on : Monday, July 4, 2022 - 8:45:34 AM
Long-term archiving on: : Tuesday, April 6, 2010 - 9:06:23 PM


  • HAL Id : inserm-00110157, version 1
  • PUBMED : 11324699



Céline Pagès, Marie-Françoise Simon, Philippe Valet, Jean Sébastien Saulnier-Blache. Lysophosphatidic acid synthesis and release.. Prostaglandins & other lipid mediators, 2001, 64 (1-4), pp.1-10. ⟨inserm-00110157⟩



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