E. Diamandis, Mass spectrometry as a diagnostic and a cancer biomarker discovery tool, Mol Cell Proteomics, vol.34, pp.367-378, 2004.

C. Deans and S. Wigmore, Systemic inflammation, cachexia and prognosis in patients with cancer, Current Opinion in Clinical Nutrition and Metabolic Care, vol.8, issue.3, pp.265-269, 2005.
DOI : 10.1097/01.mco.0000165004.93707.88

M. Tisdale, Metabolic abnormalities in cachexia and anorexia, Nutrition, vol.16, issue.10, pp.1013-1014, 2000.
DOI : 10.1016/S0899-9007(00)00409-3

D. Pouliquen, F. Foussard, G. Tanguy, J. Roux, and Y. Malthièry, Total and structured water in cancer: an NMR experimental study of serum and tissues in DMBA-induced OF1 mice, Cell Mol Biol, vol.47, pp.947-957, 2001.

G. Jendrasiak, The hydration of phospholipids and its biological significance, The Journal of Nutritional Biochemistry, vol.7, issue.11, pp.599-609, 1996.
DOI : 10.1016/S0955-2863(96)00118-0

J. Fernandez-checa and N. Kaplowitz, Hepatic mitochondrial glutathione: transport and role in disease and toxicity, Toxicology and Applied Pharmacology, vol.204, issue.3, pp.263-273, 2005.
DOI : 10.1016/j.taap.2004.10.001

D. Pouliquen, G. Bellot, G. Guihard, P. Fichet, K. Meflah et al., Mitochondrial membrane permeabilization produced by PTP, Bax and apoptosis: a 1H-NMR relaxation study, Cell Death and Differentiation, vol.35, issue.2, pp.301-310, 2006.
DOI : 10.1038/sj.cdd.4401731

A. Colell, C. Garcia-ruiz, J. Lluis, O. Coll, M. Mari et al., Cholesterol Impairs the Adenine Nucleotide Translocator-mediated Mitochondrial Permeability Transition through Altered Membrane Fluidity, Journal of Biological Chemistry, vol.278, issue.36, pp.33928-33935, 2003.
DOI : 10.1074/jbc.M210943200

P. Mourad, L. Farrell, L. Stamps, D. Chicoine, and D. Silbergeld, Why are systemic glioblastoma metastases rare? Systemic and cerebral growth of mouse glioblastoma, Surgical Neurology, vol.63, issue.6, pp.511-519, 2005.
DOI : 10.1016/j.surneu.2004.08.062

S. Hortelano, M. Garcia-martin, S. Cerdan, A. Castrillo, A. Alvarez et al., Intracellular water motion decreases in apoptotic macrophages after caspase activation, Cell Death and Differentiation, vol.8, issue.10, pp.1022-1028, 2001.
DOI : 10.1038/sj.cdd.4400913

D. Rickwood, M. Wilson, V. Darley-usmar, V. Darley-usmar, D. Rickwood et al., Isolation and characteristics of intact mitochondria, Mitochondria, pp.1-16

A. Koestner, J. Swenberg, and W. Wechsler, Transplacental production with ethylnitrosourea of neoplasms of the nervous system in Sprague-Dawley rats, Am J Pathol, vol.63, pp.37-56, 1971.

J. Gallier and P. Rivet, 1H- and 2H-NMR study of bovine serum albumin solutions, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.915, issue.1, pp.1-18, 1987.
DOI : 10.1016/0167-4838(87)90119-1

E. Bligh and W. Dyer, A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION, Canadian Journal of Biochemistry and Physiology, vol.37, issue.8, pp.911-917, 1959.
DOI : 10.1139/o59-099

A. Zlatkis and Z. B. , Study of a new cholesterol reagent, Analytical Biochemistry, vol.29, issue.1, pp.143-148, 1969.
DOI : 10.1016/0003-2697(69)90017-7

P. Juin, M. Pelletier, L. Oliver, K. Tremblais, M. Grégoire et al., Induction of a Caspase-3-like Activity by Calcium in Normal Cytosolic Extracts Triggers Nuclear Apoptosis in a Cell-free System, Journal of Biological Chemistry, vol.273, issue.28, pp.17559-17564, 1998.
DOI : 10.1074/jbc.273.28.17559

P. Mentré, An introduction to « water in the cell »: tamed hydra ?, Cell Mol Biol, vol.47, pp.709-715, 2001.

K. Kouda, H. Nakamura, H. Kohno, S. Ha-kawa, R. Tokunaga et al., Dietary restriction: effects of short-term fasting on protein uptake and cell death/proliferation in the rat liver, Mechanisms of Ageing and Development, vol.125, issue.5, pp.375-380, 2004.
DOI : 10.1016/j.mad.2004.02.006

G. Mclntyre, Cell hydration as the primary factor in carcinogenesis: a unifying concept, pp.518-526, 2006.

G. Jendrasiak and J. Hasty, The hydration of phospholipids, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.337, issue.1, pp.79-91, 1974.
DOI : 10.1016/0005-2760(74)90042-3

S. Simon, T. Mcintosh, and R. Latorre, Influence of cholesterol on water penetration into bilayers, Science, vol.216, issue.4541, pp.65-67, 1982.
DOI : 10.1126/science.7063872

A. Campbell, A. Capuano, and S. Chan, A cholesterol-binding and transporting protein from rat liver mitochondria, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1567, pp.123-132, 2002.
DOI : 10.1016/S0005-2736(02)00607-7

O. Rourke and B. , Pathophysiological and protective roles of mitochondrial ion channels, J Physiol, vol.5291, pp.23-36, 2000.

P. Brookes, Mitochondrial nitric oxide synthase, Mitochondrion, vol.3, issue.4, pp.187-204, 2004.
DOI : 10.1016/j.mito.2003.10.001

P. Chakravarty, A. Ghosh, and J. Chowdhury, Plasma and erythrocyte copper level as an indicator of disease activity during malignancy, Cancer Letters, vol.84, issue.2, pp.177-182, 1994.
DOI : 10.1016/0304-3835(94)90373-5

M. Ettinger and T. Boyer, Hepatic copper metabolism In Hepatology, a textbook of liver disease, pp.554-563

O. Khalimonchuk and G. Rödel, Biogenesis of cytochrome c oxidase, Mitochondrion, vol.5, issue.6, pp.363-388, 2005.
DOI : 10.1016/j.mito.2005.08.002
URL : https://hal.archives-ouvertes.fr/hal-00375430

H. Frey, R. Knispel, J. Kruuv, A. Sharp, R. Thompson et al., Proton spin-lattice relaxation studies of nonmalignant tissues of tumorous mice, J Natl Canc Inst, vol.49, pp.903-906, 1972.

D. Hollis, L. Saryan, J. Economou, J. Eggleston, J. Czeisler et al., Nuclear Magnetic Resonance Studies of Cancer. V. Appearance and Development of a Tumor Systemic Effect in Serum and Tissues 2, JNCI: Journal of the National Cancer Institute, vol.53, issue.3, pp.807-815, 1974.
DOI : 10.1093/jnci/53.3.807

W. Negendank, T. Corbett, M. Crowley, and C. Kellogg, Evidence for a contribution of paramagnetic ions to water proton spin-lattice relaxation in normal and malignant mouse tissues, Magnetic Resonance in Medicine, vol.10, issue.2, pp.280-293, 1991.
DOI : 10.1002/mrm.1910180204

K. Gawrisch, D. Ruston, J. Zimmerberg, V. Parsegian, R. Rand et al., Membrane dipole potentials, hydration forces, and the ordering of water at membrane surfaces, Biophysical Journal, vol.61, issue.5, pp.1213-1223, 1992.
DOI : 10.1016/S0006-3495(92)81931-8

P. Wiggins and R. Van-ryn, Changes in ionic selectivity with changes in density of water in gels and cells, Biophysical Journal, vol.58, issue.3, pp.585-596, 1987.
DOI : 10.1016/S0006-3495(90)82402-4

B. Herrera, M. Fernandez, A. Alvarez, C. Roncero, M. Benito et al., Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor ?? in rat fetal hepatocytes, Hepatology, vol.34, issue.3, pp.548-556, 2001.
DOI : 10.1053/jhep.2001.27447