I. Alsobrook, J. Leckman, W. Goodman, S. Rasmussen, and D. Pauls, Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores, American Journal of Medical Genetics, vol.24, issue.6, pp.669-75, 1999.
DOI : 10.1002/(SICI)1096-8628(19991215)88:6<669::AID-AJMG17>3.0.CO;2-N

J. Alvarez, N. Gluck, I. Arnulf, P. Quintin, M. Leboyer et al., Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: Effects of clomipramine and fluoxetine, Clinical Pharmacology & Therapeutics, vol.66, issue.6, pp.617-641, 1999.
DOI : 10.1053/cp.1999.v66.103402001

V. Arolt, R. Lencer, A. Nolte, B. Muller-myhsok, S. Purmann et al., Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease, American Journal of Medical Genetics, vol.44, issue.6, pp.564-79, 1996.
DOI : 10.1002/(SICI)1096-8628(19961122)67:6<564::AID-AJMG10>3.0.CO;2-R

L. Barr, W. Goodman, L. Price, C. Mcdougle, and D. Charney, The serotonin hypothesis of obsessive compulsive disorder: implications of pharmacologic challenge studies, J Clin Psychiatry, vol.53, pp.17-28, 1992.

B. Bastani, R. Arora, and H. Meltzer, Serotonin uptake and imipramine binding in the blood platelets of obsessive-compulsive disorder patients, Biological Psychiatry, vol.30, issue.2, pp.131-140, 1991.
DOI : 10.1016/0006-3223(91)90166-J

C. Betancur, M. Corbex, C. Spielewoy, P. A. Laplanche, J. Launay et al., Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder, Molecular Psychiatry, vol.7, issue.1, pp.67-71, 2002.
DOI : 10.1038/sj.mp.4000923

URL : https://hal.archives-ouvertes.fr/inserm-00124375

D. Black, M. Kelly, C. Myers, R. Noyes, and . Jr, Tritiated imipramine binding in obsessive-compulsive volunteers and psychiatrically normal controls, Biological Psychiatry, vol.27, issue.3, pp.319-346, 1990.
DOI : 10.1016/0006-3223(90)90006-N

P. Blier and C. De-montigny, Serotonin and Drug-Induced Therapeutic Responses in Major Depression, Obsessive???Compulsive and Panic Disorders, Neuropsychopharmacology, vol.21, issue.2, pp.91-98, 1999.
DOI : 10.1016/S0893-133X(99)00036-6

T. Brewerton, M. Flament, J. Rapoport, and D. Murphy, Seasonal effects on platelet 5-HT content in patients with OCD and controls, Arch Gen Psychiatry, vol.50, p.409, 1993.

D. Cath, P. Spinhoven, A. Landman, and G. Van-kempen, Psychopathology and personality characteristics in relation to blood serotonin in Tourette's syndrome and obsessive-compulsive disorder, Journal of Psychopharmacology, vol.15, issue.2, pp.111-120, 2001.
DOI : 10.1177/026988110101500208

D. Prada, M. Cesura, A. Launay, J. Richards, and J. , Platelets as a model for neurones?, Experientia, vol.4, issue.Suppl., pp.115-141, 1988.
DOI : 10.1007/BF01952193

R. Delorme, N. Chabane, J. Callebert, B. Falissard, M. Mouren-simeoni et al., Platelet Serotonergic Predictors of Clinical Improvement in Obsessive Compulsive Disorder, Journal of Clinical Psychopharmacology, vol.24, issue.1, pp.1-6, 2004.
DOI : 10.1097/01.jcp.0000104905.75206.50

M. Flament, J. Rapoport, D. Murphy, C. Berg, and C. Lake, Biochemical Changes During Clomipramine Treatment of Childhood Obsessive-Compulsive Disorder, Archives of General Psychiatry, vol.44, issue.3, pp.219-244, 1987.
DOI : 10.1001/archpsyc.1987.01800150025004

R. Freedman, H. Coon, M. Myles-worsley, A. Orr-urtreger, A. Olincy et al., Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus, Proceedings of the National Academy of Sciences, vol.67, issue.2, pp.587-92, 1997.
DOI : 10.1002/(SICI)1096-8628(19960409)67:2<154::AID-AJMG5>3.0.CO;2-S

W. Goodman, L. Price, S. Rasmussen, C. Mazure, R. Fleischmann et al., The Yale-Brown Obsessive Compulsive Scale, Archives of General Psychiatry, vol.46, issue.11, pp.1006-1011, 1989.
DOI : 10.1001/archpsyc.1989.01810110048007

I. Gottesman and T. Gould, The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions, American Journal of Psychiatry, vol.160, issue.4, pp.636-681, 2003.
DOI : 10.1176/appi.ajp.160.4.636

B. Greenberg, F. Mcmahon, and D. Murphy, Serotonin transporter candidate gene studies in affective disorders and personality: promises and potential pitfalls, Molecular Psychiatry, vol.3, issue.3, pp.186-195, 1998.
DOI : 10.1038/sj.mp.4000415

G. Hanna, A. Yuwiler, and D. Cantwell, Whole blood serotonin in juvenile obsessive-compulsive disorder, Biological Psychiatry, vol.29, issue.8, pp.738-782, 1991.
DOI : 10.1016/0006-3223(91)90193-P

G. Hanna, A. Yuwiler, and D. Cantwell, Whole-Blood Serotonin during Clomipramine Treatment of Juvenile Obsessive???Compulsive Disorder, Journal of Child and Adolescent Psychopharmacology, vol.3, issue.4, pp.223-229, 1993.
DOI : 10.1089/cap.1993.3.223

G. Hanna, A. Yuwiler, and J. Coates, Whole Blood Serotonin and Disruptive Behaviors in Juvenile Obsessive-Compulsive Disorder, Journal of the American Academy of Child & Adolescent Psychiatry, vol.34, issue.1, pp.28-35, 1995.
DOI : 10.1097/00004583-199501000-00010

G. Hanna, J. Veenstra-vanderweele, N. Cox, M. Boehnke, J. Himle et al., Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands, American Journal of Medical Genetics, vol.31, issue.5, pp.541-52, 2002.
DOI : 10.1002/ajmg.10519

T. Insel and J. Winslow, Neurobiology of obsessive compulsive disorder, International Clinical Psychopharmacology, vol.7, pp.813-837, 1992.
DOI : 10.1097/00004850-199206001-00008

A. Jonnal, C. Gardner, C. Prescott, and K. Kendler, Obsessive and compulsive symptoms in a general population sample of female twins, American Journal of Medical Genetics, vol.1, issue.6, pp.791-797, 2000.
DOI : 10.1002/1096-8628(20001204)96:6<791::AID-AJMG19>3.0.CO;2-C

M. Keating and M. Sanguinetti, Molecular and Cellular Mechanisms of Cardiac Arrhythmias, Cell, vol.104, issue.4, pp.569-80, 2001.
DOI : 10.1016/S0092-8674(01)00243-4

F. Kilic, D. Murphy, and G. Rudnick, A Human Serotonin Transporter Mutation Causes Constitutive Activation of Transport Activity, Molecular Pharmacology, vol.64, issue.2, pp.440-446, 2003.
DOI : 10.1124/mol.64.2.440

M. Leboyer, F. Bellivier, M. Nosten-bertrand, R. Jouvent, D. Pauls et al., Psychiatric genetics: search for phenotypes, Trends in Neurosciences, vol.21, issue.3, pp.102-107, 1998.
DOI : 10.1016/S0166-2236(97)01187-9

M. Leboyer, P. Quintin, P. Manivet, O. Varoquaux, J. Allilaire et al., Decreased serotonin transporter binding in unaffected relatives of manic depressive patients, Biological Psychiatry, vol.46, issue.12, pp.1703-1709, 1999.
DOI : 10.1016/S0006-3223(99)00178-X

M. Leboyer, Searching for Alternative Phenotypes in Psychiatric Genetics, Methods Mol Med, vol.77, pp.145-61, 2003.
DOI : 10.1385/1-59259-348-8:145

K. Lesch, D. Bengel, A. Heils, S. Sabol, B. Greenberg et al., Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region, Science, vol.274, issue.5292, pp.1527-1558, 1996.
DOI : 10.1126/science.274.5292.1527

D. Marazziti, E. Hollander, P. Lensi, S. Ravagli, and G. Cassano, Peripheral markers of serotonin and dopamine function in obsessive-compulsive disorder, Psychiatry Research, vol.42, issue.1, pp.41-51, 1992.
DOI : 10.1016/0165-1781(92)90037-4

D. Marazziti, C. Pfanner, L. Palego, A. Gemignani, A. Milanfranchi et al., Changes in Platelet Markers of Obsessive-Compulsive Patients During a Double-Blind Trial of Fluvoxamine versus Clomipramine, Pharmacopsychiatry, vol.30, issue.06, pp.245-254, 1997.
DOI : 10.1055/s-2007-979501

D. Marazziti, H. Akiskal, A. Rossi, and G. Cassano, Alteration of the platelet serotonin transporter in romantic love, Psychological Medicine, vol.29, issue.3, pp.741-746, 1999.
DOI : 10.1017/S0033291798007946

D. Marazziti, I. Masala, A. Rossi, E. Hollander, S. Presta et al., Increased Inhibitory Activity of Protein Kinase C on the Serotonin Transporter in OCD, Neuropsychobiology, vol.41, issue.4, pp.171-178, 2000.
DOI : 10.1159/000026656

G. Marek, L. Carpenter, C. Mcdougle, and L. Price, Synergistic Action of 5-HT2A Antagonists and Selective Serotonin Reuptake Inhibitors in Neuropsychiatric Disorders, Neuropsychopharmacology, vol.28, issue.2, pp.402-414, 2003.
DOI : 10.1038/sj.npp.1300057

C. Matuchansky and J. Launay, Serotonin, catecholamines, and spontaneous midgut carcinoid flush: Plasma studies from flushing and nonflushing sites, Gastroenterology, vol.108, issue.3, pp.743-51, 1995.
DOI : 10.1016/0016-5085(95)90447-6

C. Mcdougle, C. Epperson, G. Pelton, S. Wasylink, and L. Price, A Double-blind, Placebo-Controlled Study of Risperidone Addition in Serotonin Reuptake Inhibitor???Refractory Obsessive-compulsive Disorder, Archives of General Psychiatry, vol.57, issue.8, pp.794-801, 2000.
DOI : 10.1001/archpsyc.57.8.794

A. Mckenzie and J. Quinn, A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo, Proceedings of the National Academy of Sciences, vol.2, issue.4, pp.15251-15256, 1999.
DOI : 10.1038/sj.mp.4000290

G. Nestadt, T. Lan, J. Samuels, M. Riddle, O. Bienvenu et al., Complex Segregation Analysis Provides Compelling Evidence for a Major Gene Underlying Obsessive-Compulsive Disorder and for Heterogeneity by Sex, The American Journal of Human Genetics, vol.67, issue.6, pp.1611-1617, 2000.
DOI : 10.1086/316898

G. Nestadt, J. Samuels, M. Riddle, O. Bienvenu, K. Liang et al., A Family Study of Obsessive-compulsive Disorder, Archives of General Psychiatry, vol.57, issue.4, pp.358-63, 2000.
DOI : 10.1001/archpsyc.57.4.358

G. Nestadt, A. Addington, J. Samuels, K. Liang, O. Bienvenu et al., The identification of OCD-related subgroups based on comorbidity, Biological Psychiatry, vol.53, issue.10, pp.914-934, 2003.
DOI : 10.1016/S0006-3223(02)01677-3

J. Nurnberger, . Jr, M. Blehar, C. Kaufmann, C. York-cooler et al., Diagnostic Interview for Genetic Studies, Archives of General Psychiatry, vol.51, issue.11, pp.849-59, 1994.
DOI : 10.1001/archpsyc.1994.03950110009002

C. Ober, M. Abney, and M. Mcpeek, The Genetic Dissection of Complex Traits in a Founder Population, The American Journal of Human Genetics, vol.69, issue.5, pp.1068-79, 2001.
DOI : 10.1086/324025

H. Orvaschel, J. Puig-antich, W. Chambers, M. Tabrizi, and R. Johnson, Retrospective Assessment of Prepubertal Major Depression with the Kiddie-SADS-E, Journal of the American Academy of Child Psychiatry, vol.21, issue.4, pp.392-399, 1982.
DOI : 10.1016/S0002-7138(09)60944-4

N. Ozaki, D. Goldman, W. Kaye, K. Plotnicov, B. Greenberg et al., Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype, Molecular Psychiatry, vol.8, issue.11, pp.933-939, 2003.
DOI : 10.1038/sj.mp.4001365

D. Pauls, J. Alsobrook, W. Goodman, S. Rasmussen, and J. Leckman, A family study of obsessive-compulsive disorder, Am J Psychiatry, vol.152, pp.76-84, 1995.

S. Ramamoorthy and R. Blakely, Phosphorylation and Sequestration of Serotonin Transporters Differentially Modulated by Psychostimulants, Science, vol.285, issue.5428, pp.763-769, 1999.
DOI : 10.1126/science.285.5428.763

F. Sallee, H. Richman, K. Beach, G. Sethuraman, and L. Nesbitt, Platelet Serotonin Transporter in Children and Adolescents with Obsessive-Compulsive Disorder or Tourette's Syndrome, Journal of the American Academy of Child & Adolescent Psychiatry, vol.35, issue.12, pp.1647-56, 1996.
DOI : 10.1097/00004583-199612000-00017

S. Stoltenberg, G. Twitchell, G. Hanna, E. Cook, H. Fitzgerald et al., Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism, American Journal of Medical Genetics, vol.8, issue.2, pp.230-234, 2002.
DOI : 10.1002/ajmg.10187

L. Weiss, J. Veenstra-vanderweele, D. Newman, S. Kim, H. Dytch et al., Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin, European Journal of Human Genetics, vol.12, issue.11, pp.949-54, 2004.
DOI : 10.1038/sj.ejhg.5201239

M. Weissman, R. Bland, G. Canino, S. Greenwald, H. Hwu et al., The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group, J Clin Psychiatry, vol.55, pp.5-10, 1994.

A. Weizman, A. Mandel, Y. Barber, R. Weitz, A. Cohen et al., Decreased platelet imipramine binding in tourette syndrome children with obsessive-compulsive disorder, Biological Psychiatry, vol.31, issue.7, pp.705-716, 1992.
DOI : 10.1016/0006-3223(92)90280-D

V. Willour, Y. Shugart, Y. Samuels, J. Grados, M. Cullen et al., Replication Study Supports Evidence for Linkage to 9p24 in Obsessive-Compulsive Disorder, The American Journal of Human Genetics, vol.75, issue.3, pp.508-521, 2004.
DOI : 10.1086/423899

J. Yaryura-tobias, F. Neziroglu, and H. Bhagavan, Obsessive-Compulsive disorders: A serotonergic hypothesis, Neuropsychopharmacology: Proceedings of the 11th Congress of the CNIP, pp.117-125, 1979.

A. Yuwiler, S. Plotkin, E. Geller, and E. Ritvo, A rapid accurate procedure for the determination of serotonin in whole human blood, Biochemical Medicine, vol.3, issue.5, pp.426-457, 1970.
DOI : 10.1016/0006-2944(70)90010-4