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Misspecified regression model for the subdistribution hazard of a competing risk.

Abstract : We consider a competing risks setting, when evaluating the prognostic influence of an exposure on a specific cause of failure. Two main regression models are used in such analyses, the Cox cause-specific proportional hazards model and the subdistribution proportional hazards model. They are exemplified in a real data example focusing on relapse-free interval in acute leukaemia patients. We examine the properties of the estimator based on the latter model when the true model is the former. An explicit relationship between subdistribution hazards ratio and cause-specific hazards ratio is derived, assuming a flexible parametric distribution for latent failure times. Copyright (c) 2006 John Wiley & Sons, Ltd.
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https://www.hal.inserm.fr/inserm-00107416
Contributor : Aurelien Latouche <>
Submitted on : Wednesday, October 18, 2006 - 3:56:17 PM
Last modification on : Friday, March 27, 2020 - 3:00:32 AM
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Aurélien Latouche, Véronique Boisson, Sylvie Chevret, Raphaël Porcher. Misspecified regression model for the subdistribution hazard of a competing risk.. Stat Med, 2007, 28 (5), pp.965-974. ⟨10.1002/sim.2600⟩. ⟨inserm-00107416⟩

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