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Protocadherin-PC promotes androgen-independent prostate cancer cell growth.

Abstract : BACKGROUND: Protocadherin-PC (PCDH-PC) expression is upregulated in apoptosis-resistant sublines of the LNCaP human prostate cancer (CaP) cell line. Here, we assess the role of PCDH-PC in CaP cells and its mRNA expression in human prostate tissues. METHODS: LNCaP cells transfected with PCDH-PC were tested for their ability to grow in vitro and in vivo in androgen-deprived conditions. PCDH-PC mRNA expression was evaluated by semi-quantitative RT-PCR and by in situ hybridization. RESULTS: PCDH-PC expression induced Wnt signaling in CaP cells and permitted androgen-independent growth of hormone-sensitive CaP cells. Expression of PCDH-PC-homologous transcripts was low and restricted to some epithelial cells in normal tissue and to CaP cells in tumors. However, hormone-resistant CaP cells expressed significantly higher levels of PCDH-PC-related mRNA. CONCLUSIONS: Our findings suggest a novel mechanism for the progression of CaP involving expression of PCDH-PC. This novel protocadherin induces Wnt signaling, promotes malignant behavior and hormone-resistance of CaP cells.
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Contributor : Stéphane Terry <>
Submitted on : Sunday, October 15, 2006 - 2:12:39 PM
Last modification on : Tuesday, April 20, 2021 - 4:54:04 PM

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Stephane Terry, Luis Queires, Sixtina Gil-Diez-De-Medina, Min-Wei Chen, Alexandre de la Taille, et al.. Protocadherin-PC promotes androgen-independent prostate cancer cell growth.. Prostate, Wiley, 2006, 66 (10), pp.1100-13. ⟨10.1002/pros.20446⟩. ⟨inserm-00106397⟩



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