O. Dowd, B. Heiber, M. Chan, and A. , A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11, Gene, vol.136, issue.1-2, pp.355-60, 1993.
DOI : 10.1016/0378-1119(93)90495-O

E. Devic, K. Rizzoti, and S. Bodin, Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ, Mechanisms of Development, vol.84, issue.1-2, pp.199-203, 1999.
DOI : 10.1016/S0925-4773(99)00081-7

O. Carroll, A. Selby, T. Palkovits, and M. , Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol.1492, issue.1, pp.72-80, 2000.
DOI : 10.1016/S0167-4781(00)00072-5

D. Mota, N. Lenkei, Z. Llorens-cortes, and C. , Cloning, Pharmacological Characterization and Brain Distribution of the Rat Apelin Receptor, Neuroendocrinology, vol.72, issue.6, pp.400-407, 2000.
DOI : 10.1159/000054609

K. Tatemoto, M. Hosoya, and Y. Habata, Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor, Biochemical and Biophysical Research Communications, vol.251, issue.2, pp.471-477, 1998.
DOI : 10.1006/bbrc.1998.9489

Y. Habata, R. Fujii, and M. Hosoya, Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1452, issue.1, pp.25-35, 1999.
DOI : 10.1016/S0167-4889(99)00114-7

D. Lee, R. Cheng, and T. Nguyen, Characterization of Apelin, the Ligand for the APJ Receptor, Journal of Neurochemistry, vol.62, issue.1, pp.34-41, 2000.
DOI : 10.1046/j.1471-4159.2000.0740034.x

D. Mota, N. , R. Goazigo, A. Messari, and S. , Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release, Proceedings of the National Academy of Sciences, vol.99, issue.2-3, pp.10464-10473, 2004.
DOI : 10.1016/S0167-0115(01)00236-1

Y. Kawamata, Y. Habata, and S. Fukusumi, Molecular properties of apelin: tissue distribution and receptor binding, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1538, issue.2-3, pp.162-71, 2001.
DOI : 10.1016/S0167-4889(00)00143-9

M. Zou, H. Liu, and Y. Haraguchi, Apelin peptides block the entry of human immunodeficiency virus (HIV), FEBS Letters, vol.274, issue.1, pp.15-23, 2000.
DOI : 10.1016/S0014-5793(00)01487-3

A. Medhurst, C. Jennings, and M. Robbins, Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin, Journal of Neurochemistry, vol.84, issue.5, pp.1162-72, 2003.
DOI : 10.1046/j.1471-4159.2003.01587.x

A. Reaux, D. Mota, N. Skultetyova, and I. , Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain, Journal of Neurochemistry, vol.473, issue.4, pp.1085-96, 2001.
DOI : 10.1046/j.1471-4159.2001.00320.x

E. Messari, S. Iturrioz, X. Fassot, and C. , Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure, Journal of Neurochemistry, vol.90, issue.6, pp.1290-301, 2004.
DOI : 10.1111/j.1471-4159.2004.02591.x
URL : https://hal.archives-ouvertes.fr/inserm-00424423

B. Masri, N. Morin, and M. Cornu, Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells, The FASEB Journal, vol.18, pp.1909-1920, 2004.
DOI : 10.1096/fj.04-1930fje
URL : https://hal.archives-ouvertes.fr/inserm-00481005

A. Reaux, K. Gallatz, M. Palkovits, and C. Llorens-cortes, Distribution of apelin-synthesizing neurons in the adult rat brain, Neuroscience, vol.113, issue.3, pp.653-62, 2002.
DOI : 10.1016/S0306-4522(02)00192-6

G. Brailoiu, S. Dun, and J. Yang, Apelin-immunoreactivity in the rat hypothalamus and pituitary, Neuroscience Letters, vol.327, issue.3, pp.193-200, 2002.
DOI : 10.1016/S0304-3940(02)00411-1

R. Goazigo, A. Morinville, A. Burlet, and A. , Dehydration-Induced Cross-Regulation of Apelin and Vasopressin Immunoreactivity Levels in Magnocellular Hypothalamic Neurons, Endocrinology, vol.145, issue.9, pp.4392-400, 2004.
DOI : 10.1210/en.2004-0384

A. Johnson, J. Cunningham, and R. Thunhorst, INTEGRATIVE ROLE OF THE LAMINA TERMINALIS IN THE REGULATION OF CARDIOVASCULAR AND BODY FLUID HOMEOSTASIS, Clinical and Experimental Pharmacology and Physiology, vol.10, issue.2, pp.183-91, 1996.
DOI : 10.1016/0306-4522(95)00050-S

O. Carroll, A. Lolait, and S. , Regulation of Rat APJ Receptor Messenger Ribonucleic Acid Expression in Magnocellular Neurones of the Paraventricular and Supraopric Nuclei by Osmotic Stimuli, Journal of Neuroendocrinology, vol.13, issue.7, pp.661-667, 2003.
DOI : 10.1046/j.1365-2826.2003.01044.x

A. Hurbin, L. Boissin-agasse, and H. Orcel, , Vasopressin Receptor Genes Are Expressed in the Supraoptic Nucleus of the Rat Hypothalamus, and the Transcripts Are Essentially Colocalized in the Vasopressinergic Magnocellular Neurons, Endocrinology, vol.139, issue.11, pp.4701-4708, 1998.
DOI : 10.1210/endo.139.11.6320

M. Brownstein, J. Russell, and H. Gainer, Synthesis, transport, and release of posterior pituitary hormones, Science, vol.207, issue.4429, pp.373-381, 1980.
DOI : 10.1126/science.6153132

M. Manning, J. Lowbridge, and J. Haldar, Design of neurohypophyseal peptides that exhibit selective agonistic and antagonistic properties, Fed Proc, vol.36, pp.1848-52, 1977.

S. Zini, M. Fournie-zaluski, and E. Chauvel, Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release., Proceedings of the National Academy of Sciences, vol.93, issue.21, pp.11968-73, 1996.
DOI : 10.1073/pnas.93.21.11968

J. Gutkowska, J. Antunes-rodrigues, and S. Mccann, Atrial natriuretic peptide in brain and pituitary gland, Physiol Rev, vol.77, pp.465-515, 1997.

D. Poulain, J. Wakerley, and R. Dyball, Electrophysiological Differentiation of Oxytocin- and Vasopressin-Secreting Neurones, Proceedings of the Royal Society B: Biological Sciences, vol.196, issue.1125, pp.367-84, 1977.
DOI : 10.1098/rspb.1977.0046

L. Gouzenes, M. Desarmenien, and N. Hussy, Vasopressin regularizes the phasic firing pattern of rat hypothalamic magnocellular vasopressin neurons, J Neurosci, vol.18, pp.1879-85, 1998.

M. Ludwig, Dendritic Release of Vasopressin and Oxytocin, Journal of Neuroendocrinology, vol.7, issue.12, pp.881-95, 1998.
DOI : 10.1046/j.1365-2826.1998.00279.x

M. Hosoya, Y. Kawamata, and S. Fukusumi, Molecular and Functional Characteristics of APJ. TISSUE DISTRIBUTION OF mRNA AND INTERACTION WITH THE ENDOGENOUS LIGAND APELIN, Journal of Biological Chemistry, vol.275, issue.28, pp.21061-21068, 2000.
DOI : 10.1074/jbc.M908417199

D. Falco, M. , D. Luca, L. Onori, and N. , Apelin expression in normal human tissues, In Vivo, vol.16, pp.333-339, 2002.

D. Denton, M. Mckinley, and R. Weisinger, Hypothalamic integration of body fluid regulation., Proceedings of the National Academy of Sciences, vol.93, issue.14, pp.7397-404, 1996.
DOI : 10.1073/pnas.93.14.7397

K. Tatemoto, K. Takayama, and M. Zou, The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism, Regulatory Peptides, vol.99, issue.2-3, pp.87-92, 2001.
DOI : 10.1016/S0167-0115(01)00236-1

I. Szokodi, P. Tavi, and G. Foldes, Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility, Circulation Research, vol.91, issue.5, pp.434-474, 2002.
DOI : 10.1161/01.RES.0000033522.37861.69

M. Chen, E. Ashley, and D. Deng, Novel Role for the Potent Endogenous Inotrope Apelin in Human Cardiac Dysfunction, Circulation, vol.108, issue.12, pp.1432-1441, 2003.
DOI : 10.1161/01.CIR.0000091235.94914.75

M. Berry, T. Pirolli, and V. Jayasankar, Apelin Has In Vivo Inotropic Effects on Normal and Failing Hearts, Circulation, vol.110, issue.11_suppl_1, pp.187-93, 2004.
DOI : 10.1161/01.CIR.0000138382.57325.5c

E. Ashley, J. Powers, and M. Chen, The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo, Cardiovascular Research, vol.65, issue.1, pp.73-82, 2005.
DOI : 10.1016/j.cardiores.2004.08.018

G. Földes, F. Horkay, and I. Szokodi, Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure, Biochemical and Biophysical Research Communications, vol.308, issue.3, pp.480-485, 2003.
DOI : 10.1016/S0006-291X(03)01424-4