P. Cohen, The role of protein phosphorylation in human health and disease.???, European Journal of Biochemistry, vol.377, issue.19, pp.5001-5010, 2001.
DOI : 10.1046/j.0014-2956.2001.02473.x

P. Cohen, Protein kinases ??? the major drug targets of the twenty-first century?, Nature Reviews Drug Discovery, vol.377, issue.4, pp.309-315, 2002.
DOI : 10.1016/S1097-2765(01)00253-2

J. Dancey and E. Sausville, Issues and progress with protein kinase inhibitors for cancer treatment, Nature Reviews Drug Discovery, vol.2, issue.4, pp.296-313, 2003.
DOI : 10.1038/nrd1066

L. Meijer and R. E. , Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials, Accounts of Chemical Research, vol.36, issue.6, pp.417-425, 2003.
DOI : 10.1021/ar0201198

URL : https://hal.archives-ouvertes.fr/hal-00020144

C. Doerig, Protein kinases as targets for anti-parasitic chemotherapy, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1697, issue.1-2, pp.155-168, 2004.
DOI : 10.1016/j.bbapap.2003.11.021

B. Kappes, C. Doerig, and R. Graeser, An Overview of Plasmodium Protein Kinases, Parasitology Today, vol.15, issue.11, pp.449-54, 1999.
DOI : 10.1016/S0169-4758(99)01527-6

C. Doerig, L. Meijer, and J. Mottram, Protein kinases as drug targets in parasitic protozoa, Trends in Parasitology, vol.18, issue.8, pp.366-371, 2002.
DOI : 10.1016/S1471-4922(02)02321-8

J. Kissinger, B. Brunk, J. Crabtree, M. Fraunholz, B. Gajria et al., The Plasmodium genome database, Nature, vol.419, issue.6906, pp.490-492, 2002.
DOI : 10.1038/419490a

S. Hanks and A. Quinn, [2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members, Methods Enzymol, vol.200, pp.38-62, 1991.
DOI : 10.1016/0076-6879(91)00126-H

T. Hunter and G. Plowman, The protein kinases of budding yeast: six score and more, Trends in Biochemical Sciences, vol.22, issue.1, pp.18-22, 1997.
DOI : 10.1016/S0968-0004(96)10068-2

D. Morrison, M. Murakami, and V. Cleghon, Genome, The Journal of Cell Biology, vol.143, issue.2, pp.57-62, 2000.
DOI : 10.1016/S0968-0004(98)01309-7

URL : https://hal.archives-ouvertes.fr/hal-00154418

G. Plowman, S. Sudarsanam, J. Bingham, D. Whyte, and T. Hunter, The protein kinases of Caenorhabditis elegans: A model for signal transduction in multicellular organisms, Proceedings of the National Academy of Sciences, vol.12, issue.10, pp.13603-13610, 1999.
DOI : 10.1101/gad.12.10.1425

M. Kostich, J. English, V. Madison, F. Gheyas, L. Wang et al., Human members of the eukaryotic protein kinase family, Genome Biol, vol.3, p.43, 2002.

G. Manning, D. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam, The Protein Kinase Complement of the Human Genome, Science, vol.298, issue.5600, pp.1912-1934, 2002.
DOI : 10.1126/science.1075762

S. Hanks, Genomic analysis of the eukaryotic protein kinase superfamily: a perspective, Genome Biology, vol.4, issue.5, p.111, 2003.
DOI : 10.1186/gb-2003-4-5-111

A. Champion, M. Kreis, K. Mockaitis, A. Picaud, and Y. Henry, Arabidopsis kinome: after the casting, Functional & Integrative Genomics, vol.4, issue.3, pp.163-187, 2004.
DOI : 10.1007/s10142-003-0096-4

S. Shiu and W. Li, Origins, Lineage-Specific Expansions, and Multiple Losses of Tyrosine Kinases in Eukaryotes, Molecular Biology and Evolution, vol.21, issue.5, pp.828-840, 2004.
DOI : 10.1093/molbev/msh077

S. Baldauf, The Deep Roots of Eukaryotes, Science, vol.300, issue.5626, pp.1703-1706, 2003.
DOI : 10.1126/science.1085544

S. Barik and R. Taylor, Chakrabarti D: Identification, cloning, and mutational analysis of the casein kinase 1 cDNA of the

D. Dorin, L. Roch, K. Sallicandro, P. Alano, P. Parzy et al., Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum, European Journal of Biochemistry, vol.3, issue.9, pp.2600-2608, 2001.
DOI : 10.1046/j.1432-1327.2001.02151.x

D. Dorin, J. Semblat, P. Poullet, P. Alano, D. Goldring et al., PfPK7, an atypical MEK-related protein kinase, reflects the absence of typical three-component MAP kinase pathways in the human malaria parasite Plasmodium falciparum, Mol Microbiol, 2004.

O. Connell, M. Krien, M. Hunter, and T. , Never say never. The NIMA-related protein kinases in mitotic control, Trends in Cell Biology, vol.13, issue.5, pp.221-228, 2003.
DOI : 10.1016/S0962-8924(03)00056-4

V. Bracchi, G. Langsley, J. Thelu, and W. Eling, PfKIN, an SNF1 type protein kinase of Plasmodium falciparum predominantly expressed in gametocytes, Molecular and Biochemical Parasitology, vol.76, issue.1-2, pp.299-303, 1996.
DOI : 10.1016/0166-6851(96)02564-9

J. Mohrle, Y. Zhao, B. Wernli, R. Franklin, and B. Kappes, Molecular cloning, characterization and localization of PfPK4, an eIF- 2alpha kinase-related enzyme from the malarial parasite Plasmodium falciparum, Biochem J, issue.2, pp.328677-687, 1997.

J. Kun, A. Hibbs, A. Saul, D. Mccoll, R. Coppel et al., A putative Plasmodium falciparum exported serine/threonine protein kinase1Note: The sequence reported in this paper has been submitted to the GenBank??? data base with the accession number U40232.1, Molecular and Biochemical Parasitology, vol.85, issue.1, pp.41-51, 1997.
DOI : 10.1016/S0166-6851(96)02805-8

M. Abe, M. Saelzler, R. Espinosa, K. Kahle, M. Hershenson et al., ERK8, a New Member of the Mitogen-activated Protein Kinase Family, Journal of Biological Chemistry, vol.277, issue.19, pp.16733-16743, 2002.
DOI : 10.1074/jbc.M112483200

M. Abe, W. Kuo, M. Hershenson, and M. Rosner, Extracellular Signal-Regulated Kinase 7 (ERK7), a Novel ERK with a C-Terminal Domain That Regulates Its Activity, Its Cellular Localization, and Cell Growth, Molecular and Cellular Biology, vol.19, issue.2, pp.1301-1312, 1999.
DOI : 10.1128/MCB.19.2.1301

M. Abe, K. Kahle, M. Saelzler, K. Orth, J. Dixon et al., ERK7 Is an Autoactivated Member of the MAPK Family, Journal of Biological Chemistry, vol.276, issue.24, pp.21272-21279, 2001.
DOI : 10.1074/jbc.M100026200

P. Ross-macdonald, R. Graeser, B. Kappes, R. Franklin, and D. Williamson, Isolation and expression of a gene specifying a cdc2-like protein kinase from the human malaria parasite Plasmodium falciparum, European Journal of Biochemistry, vol.106, issue.3, pp.693-701, 1994.
DOI : 10.1016/0166-6851(84)90021-5

L. Roch, K. Sestier, C. Dorin, D. Waters, N. Kappes et al., Activation of a Plasmodium falciparum cdc2-related Kinase by Heterologous p25 and Cyclin H. FUNCTIONAL CHARACTERIZATION OF A P. FALCIPARUM CYCLIN HOMOLOGUE, Journal of Biological Chemistry, vol.275, issue.12, pp.8952-8958, 2000.
DOI : 10.1074/jbc.275.12.8952

C. Doerig, P. Horrocks, J. Coyle, J. Carlton, A. Sultan et al., Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.70, issue.1-2, pp.167-174, 1995.
DOI : 10.1016/0166-6851(95)00033-W

J. Li, K. Robson, J. Chen, G. Targett, and D. Baker, Pfmrk, A MO15-Related Protein Kinase from Plasmodium falciparum. Gene Cloning, Sequence, Stage-Specific Expression and Chromosome Localization, European Journal of Biochemistry, vol.55, issue.3, pp.805-813, 1996.
DOI : 10.1016/0092-8674(87)90539-3

N. Waters, C. Woodard, and S. Prigge, Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.107, issue.1, pp.45-55, 2000.
DOI : 10.1016/S0166-6851(99)00229-7

S. Holton, A. Merckx, D. Burgess, C. Doerig, M. Noble et al., Structures of P. falciparum PfPK5 Test the CDK Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition, Structure, vol.11, issue.11, pp.1329-1337, 2003.
DOI : 10.1016/j.str.2003.09.020

A. Merckx, L. Roch, K. Nivez, M. Dorin, D. Alano et al., Identification and Initial Characterization of Three Novel Cyclin-related Proteins of the Human Malaria Parasite Plasmodium falciparum, Journal of Biological Chemistry, vol.278, issue.41, pp.39839-39850, 2003.
DOI : 10.1074/jbc.M301625200

G. Dellaire, E. Makarov, J. Cowger, D. Longman, H. Sutherland et al., Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes, Molecular and Cellular Biology, vol.22, issue.14, pp.5141-5156, 2002.
DOI : 10.1128/MCB.22.14.5141-5156.2002

T. Gross, M. Lutzelberger, H. Weigmann, A. Klingenhoff, S. Shenoy et al., Functional Analysis of the Fission Yeast Prp4 Protein Kinase Involved in Pre-Mrna Splicing and Isolation of a Putative Mammalian Homologue, Nucleic Acids Research, vol.25, issue.5, pp.1028-1035, 1997.
DOI : 10.1093/nar/25.5.1028

C. Siebel, L. Feng, C. Guthrie, and X. Fu, Conservation in budding yeast of a kinase specific for SR splicing factors, Proceedings of the National Academy of Sciences, vol.16, issue.12, pp.5440-5445, 1999.
DOI : 10.1073/pnas.93.14.6975

H. Wang, K. Arden, J. R. Bermingham, . Jr, C. Viars et al., Localization of Serine Kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), Specific for the SR Family of Splicing Factors in Mouse and Human Chromosomes, Genomics, vol.57, issue.2, pp.310-315, 1999.
DOI : 10.1006/geno.1999.5770

R. Padmanabha, S. Gehrung, and M. Snyder, The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family, MGG Molecular & General Genetics, vol.229, issue.1, pp.1-9, 1991.
DOI : 10.1007/BF00264206

J. Prasad and J. Manley, Regulation and Substrate Specificity of the SR Protein Kinase Clk/Sty, Molecular and Cellular Biology, vol.23, issue.12, pp.4139-4149, 2003.
DOI : 10.1128/MCB.23.12.4139-4149.2003

G. Moulton, T. Attwood, D. Parry-smith, and J. Packer, Phylogenomic Analysis and Evolution of the Potassium Channel Gene Family, Receptors and Channels, vol.3, issue.6, pp.363-377, 2003.
DOI : 10.3109/714041017

C. Smith, E. Radzio-andzelm, . Madhusudan, P. Akamine, and S. Taylor, The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication, Progress in Biophysics and Molecular Biology, vol.71, issue.3-4, pp.313-341, 1999.
DOI : 10.1016/S0079-6107(98)00059-5

E. Bischoff, M. Guillotte, O. Mercereau-puijalon, and S. Bonnefoy, A member of the Plasmodium falciparum Pf60 multigene family codes for a nuclear protein expressed by readthrough of an internal stop codon, Molecular Microbiology, vol.19, issue.5, pp.1005-1016, 2000.
DOI : 10.1016/0166-6851(88)90066-7

M. Duffy, J. Reeder, and G. Brown, Regulation of antigenic variation in Plasmodium falciparum: censoring freedom of expression? Trends Parasitol, pp.121-124, 2003.

S. Kyes, J. Rowe, N. Kriek, and C. Newbold, Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum, Proceedings of the National Academy of Sciences, vol.17, issue.18, pp.9333-9338, 1999.
DOI : 10.1093/emboj/17.18.5418

S. Bonnefoy, M. Guillotte, G. Langsley, and O. Mercereau-puijalon, Plasmodium falciparum: Characterization of gene R45 encoding a trophozoite antigen containing a central block of six amino acid repeats, Experimental Parasitology, vol.74, issue.4, pp.441-451, 1992.
DOI : 10.1016/0014-4894(92)90206-P

D. Morrison, KSR: a MAPK scaffold of the Ras pathway?, J Cell Sci, vol.114, pp.1609-1612, 2001.

B. Foth and G. Mcfadden, The apicoplast: A plastid in Plasmodium falciparum and other apicomplexan parasites, Int Rev Cytol, vol.224, pp.57-110, 2003.
DOI : 10.1016/S0074-7696(05)24003-2

W. Martin and R. Herrmann, Gene transfer from organelles to the nucleus: how much, what happens, and Why? Plant Physiol, pp.9-17, 1998.

B. Foth, S. Ralph, C. Tonkin, N. Struck, M. Fraunholz et al., Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum, Science, vol.299, issue.5607, pp.705-708, 2003.
DOI : 10.1126/science.1078599

A. Bender, G. Van-dooren, S. Ralph, G. Mcfadden, and G. Schneider, Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.132, issue.2, pp.59-66, 2003.
DOI : 10.1016/j.molbiopara.2003.07.001

T. Geerlings, A. Faber, M. Bister, J. Vos, and H. Raue, Rio2p, an Evolutionarily Conserved, Low Abundant Protein Kinase Essential for Processing of 20 S Pre-rRNA in Saccharomyces cerevisiae, Journal of Biological Chemistry, vol.278, issue.25, pp.22537-22545, 2003.
DOI : 10.1074/jbc.M300759200

N. Elabbadi, M. Ancelin, and H. Vial, Characterization of phosphatidylinositol synthase and evidence of a polyphosphoinositide cycle in Plasmodium-infected erythrocytes, Molecular and Biochemical Parasitology, vol.63, issue.2, pp.179-192, 1994.
DOI : 10.1016/0166-6851(94)90054-X

R. Bosotti, A. Isacchi, and E. Sonnhammer, FAT: a novel domain in PIK-related kinases, Trends in Biochemical Sciences, vol.25, issue.5, pp.225-227, 2000.
DOI : 10.1016/S0968-0004(00)01563-2

Z. Bozdech, J. Zhu, M. Joachimiak, F. Cohen, B. Pulliam et al., Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray, Genome Biology, vol.4, issue.2, p.9, 2003.
DOI : 10.1186/gb-2003-4-2-r9

L. Roch, K. Zhou, Y. Blair, P. Grainger, M. Moch et al., Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle, Science, vol.301, issue.5639, pp.1503-1508, 2003.
DOI : 10.1126/science.1087025

C. Mungall, J. Venter, D. Carucci, S. Hoffman, C. Newbold et al., Genome sequence of the human malaria parasite Plasmodium falciparum, Nature, vol.419, pp.498-511, 2002.

S. Eddy, Profile hidden Markov models, Bioinformatics, vol.14, issue.9, pp.755-763, 1998.
DOI : 10.1093/bioinformatics/14.9.755

A. Bateman, E. Birney, L. Cerruti, R. Durbin, L. Etwiller et al., The Pfam Protein Families Database, Nucleic Acids Research, vol.30, issue.1, pp.276-280, 2002.
DOI : 10.1093/nar/30.1.276

URL : https://hal.archives-ouvertes.fr/hal-01294685

M. Ashburner, C. Ball, J. Blake, D. Botstein, H. Butler et al., Gene Ontology: tool for the unification of biology, Nature Genetics, vol.9, issue.1, pp.25-29, 2000.
DOI : 10.1038/75556

K. Rutherford, J. Parkhill, J. Crook, T. Horsnell, P. Rice et al., Artemis: sequence visualization and annotation, Bioinformatics, vol.16, issue.10, pp.944-945, 2000.
DOI : 10.1093/bioinformatics/16.10.944

URL : http://bioinformatics.oxfordjournals.org/cgi/content/short/16/10/944

J. Felsenstein, PHYLIP (Phylogeny Inference Package) version 36a3 Distributed by the author Department of Genome Sciences, 2002.