C. Rabuel and A. Mebazaa, Septic shock: a heart story since the 1960s, Intensive Care Medicine, vol.268, issue.6, pp.799-807, 2006.
DOI : 10.1007/s00134-006-0142-5

S. Besse, P. Assayag, C. Delcayre, F. Carre, S. Cheav et al., Normal and hypertrophied senescent rat heart: mechanical and molecular characteristics, Am J Physiol, vol.265, pp.183-190, 1993.

P. Assayag, D. Charlemagne, D. Leiris, J. Boucher, F. Valere et al., Senescent Heart Compared With Pressure Overload-Induced Hypertrophy, Hypertension, vol.29, issue.1, pp.15-21, 1997.
DOI : 10.1161/01.HYP.29.1.15

E. Lakatta, Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part III: Cellular and Molecular Clues to Heart and Arterial Aging, Circulation, vol.107, issue.3, pp.490-497, 2003.
DOI : 10.1161/01.CIR.0000048894.99865.02

H. Saito and J. Papaconstantinou, Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress, Journal of Biological Chemistry, vol.276, issue.31, pp.29307-29312, 2001.
DOI : 10.1074/jbc.M103740200

B. Tavernier, D. Garrigue, C. Boulle, and B. Vallet, Myofilament calcium sensitivity is decreased in skinned cardiac fibres of endotoxin-treated rabbits, Cardiovascular Research, vol.38, issue.2, pp.472-479, 1998.
DOI : 10.1016/S0008-6363(98)00028-5

B. Tavernier, J. Li, M. El-omar, S. Lanone, Z. Yang et al., Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats, The FASEB Journal, vol.15, pp.294-296, 2001.
DOI : 10.1096/fj.00-0433fje

J. Layland, A. Cave, C. Warren, D. Grieve, E. Sparks et al., Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skelettal troponin I, FASEB J, vol.19, pp.1137-1139, 2005.

B. Tavernier, A. Mebazaa, P. Mateo, S. Sys, R. Ventura-clapier et al., Sensitivity but Normal Mitochondrial Function in Septic Heart, American Journal of Respiratory and Critical Care Medicine, vol.163, issue.2, pp.362-367, 2001.
DOI : 10.1164/ajrccm.163.2.2002128

V. Faivre, H. Kaskos, J. Callebert, M. Losser, P. Milliez et al., Cardiac and Renal Effects of Levosimendan, Arginine Vasopressin, and Norepinephrine in Lipopolysaccharide-treated Rabbits, Anesthesiology, vol.103, issue.3, pp.514-521, 2005.
DOI : 10.1097/00000542-200509000-00014

A. Morelli, D. Castro, S. Teboul, J. Singer, M. et al., Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression, Intensive Care Medicine, vol.223, issue.5, pp.638-644, 2005.
DOI : 10.1007/s00134-005-2619-z

N. Abi-gerges, B. Tavernier, A. Mebazaa, V. Faivre, X. Paqueron et al., Sequential changes in autonomic regulation of cardiac myocytes after in vivo endotoxin injection in rat

P. Best, Cardiac muscle function: results from skinned fiber preparations, Am J Physiol, vol.244, pp.167-177, 1983.

A. Fabiato and F. Fabiato, Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells, J Physiol (Paris), vol.75, pp.463-505, 1979.

A. Lukaszevicz, A. Mebazaa, J. Callebert, M. J. Gatecel, C. Kechiche et al., Lack of alteration of endogenous nitric oxide pathway during prolonged nitric oxide inhalation in intensive care unit patients*, Critical Care Medicine, vol.33, issue.5, pp.1008-1014, 2005.
DOI : 10.1097/01.CCM.0000163233.00458.DD

K. Kikugawa, T. Kujima, S. Yamaki, and H. Kosugi, Interpretation of the thiobarbituric acid reactivity of rat liver and brain homogenates in the presence of ferric ion and ethylenediaminetetraacetic acid, Analytical Biochemistry, vol.202, issue.2, pp.249-255, 1992.
DOI : 10.1016/0003-2697(92)90102-D

H. Aebi, [13] Catalase in vitro, Methods Enzymol, vol.105, pp.121-126, 1984.
DOI : 10.1016/S0076-6879(84)05016-3

D. Paglia and W. Valentine, Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase, J Lab Clin Med, vol.70, pp.158-169, 1967.

X. Meng, L. Ao, D. Meldrum, B. Cain, B. Shames et al., TNF alpha and myocardial depression in endotoxemic rats: temporal discordance of an obligatory relationship, Am J Physiol, vol.275, pp.502-508, 1998.

I. Turnbull, J. Wizorek, D. Osborne, R. Hotchkiss, C. Coopersmith et al., Effects of Age on Mortality and Antibiotic Efficacy in Cecal Ligation and Puncture, Shock, vol.19, issue.4, pp.310-313, 2003.
DOI : 10.1097/00024382-200304000-00003

H. Saito, E. Sherwood, T. Varma, and B. Evers, Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis, Mechanisms of Ageing and Development, vol.124, issue.10-12, pp.1047-1058, 2003.
DOI : 10.1016/j.mad.2003.08.002

B. Chorinchath, L. Kong, L. Mao, and R. Mccallum, Age-associated differences in TNF alpha and nitric oxide production in endotoxic mice, J Immunol, vol.156, pp.1525-1530, 1996.

K. Tateda, T. Matsumoto, S. Miyazaki, and K. Yamaguchi, Lipopolysaccharide-induced lethality and cytokine production in aged mice, Infect Immun, vol.64, pp.769-774, 1996.

P. Marik and G. Zaloga, the Norasept II study investigators: North American sepsis trial II. The effect of aging on circulating levels of proinflammatory cytokines during septic shock

S. Zieman, G. Gerstenblith, E. Lakatta, G. Rosas, K. Vandegaer et al., Upregulation of the Nitric Oxide-cGMP Pathway in Aged Myocardium : Physiological Response to l-Arginine, Circulation Research, vol.88, issue.1, pp.97-102, 2001.
DOI : 10.1161/01.RES.88.1.97

G. Rosas, S. Zieman, M. Donabedian, K. Vandegaer, and J. Hare, Augmented Age-associated Innate Immune Responses Contribute to Negative Inotropic and Lusitropic Effects of Lipopolysaccharide and Interferon ??, Journal of Molecular and Cellular Cardiology, vol.33, issue.10, pp.1849-1859, 2001.
DOI : 10.1006/jmcc.2001.1448

B. Yang, D. Larson, and R. Watson, Modulation of iNOS activity in age-related cardiac dysfunction, Life Sciences, vol.75, issue.6, pp.655-667, 2004.
DOI : 10.1016/j.lfs.2003.09.076

M. Iqbal, R. Cohen, K. Marzouk, and S. Liu, Time course of nitric oxide, peroxynitrite, and antioxidants in the endotoxemic heart, Critical Care Medicine, vol.30, issue.6, pp.1291-1296, 2002.
DOI : 10.1097/00003246-200206000-00021

M. Astiz, E. Rackow, and M. Weil, Schumer W: Early impairment of oxidative metabolism and energy production in severe sepsis, Circ Shock, vol.26, pp.311-320, 1988.

C. Ritter, M. Andrades, M. Frota, F. Bonatto, R. Pinho et al., Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation, Intensive Care Medicine, vol.29, issue.10, pp.1782-1789, 2003.
DOI : 10.1007/s00134-003-1789-9

M. Andrades, C. Ritter, J. Moreira, and F. Dal-pizzol, Oxidative Parameters Differences during Non-Lethal and Lethal Sepsis Development1, Journal of Surgical Research, vol.125, issue.1, pp.68-72, 2005.
DOI : 10.1016/j.jss.2004.11.008

S. Yasuda and W. Lew, Lipopolysaccharide Depresses Cardiac Contractility and ??-Adrenergic Contractile Response by Decreasing Myofilament Response to Ca2+ in Cardiac Myocytes, Circulation Research, vol.81, issue.6, pp.1011-1020, 1997.
DOI : 10.1161/01.RES.81.6.1011

M. Ming, D. Hu, H. Chen, L. Liu, X. Nan et al., EFFECT OF MCI-154, A CALCIUM SENSITIZER, ON CALCIUM SENSITIVITY OF MYOCARDIAL FIBERS IN ENDOTOXIC SHOCK RATS, Shock, vol.14, issue.6, pp.652-656, 2000.
DOI : 10.1097/00024382-200014060-00014

J. Layland, R. Solaro, and A. Shah, Regulation of cardiac contractile function by troponin I phosphorylation, Cardiovascular Research, vol.66, issue.1, pp.12-21, 2005.
DOI : 10.1016/j.cardiores.2004.12.022

S. Yang, C. Hsu, S. Lue, H. Hsu, and M. Liu, PROTEIN KINASE A ACTIVITY IS INCREASED IN RAT HEART DURING LATE HYPODYNAMIC PHASE OF SEPSIS, Shock, vol.8, issue.1, pp.68-72, 1997.
DOI : 10.1097/00024382-199707000-00011

E. Lakatta, Cardiovascular regulatory mechanisms in advanced age, Physiol Rev, vol.73, pp.413-465, 1993.

J. Parrillo, Pathogenetic mechanisms of septic shock, N Engl J Med, vol.328, pp.1471-1477, 1993.

A. Vieillard-baron, J. Schmitt, A. Beauchet, R. Augarde, S. Prin et al., Early Preload Adaptation in Septic Shock?, Anesthesiology, vol.94, issue.3, pp.400-406, 2001.
DOI : 10.1097/00000542-200103000-00007