A. Rickinson, E. Kieff, . Bn, D. Knipe, and P. Howley, Epstein???Barr virus, Virus Research, vol.82, issue.1-2, pp.2397-2446, 1996.
DOI : 10.1016/S0168-1702(01)00436-1
URL : https://hal.archives-ouvertes.fr/inserm-00508046

M. Massuci and I. Ernberg, Epstein-Barr virus: adaptation to a life within the immune system, Trends in Microbiology, vol.2, issue.4, pp.125-130, 1994.
DOI : 10.1016/0966-842X(94)90599-1

J. Sixbey, J. Nedrud, N. Raab-traub, R. Hanes, and J. Pagano, Epstein???Barr Virus Replication in Oropharyngeal Epithelial Cells, New England Journal of Medicine, vol.310, issue.19, pp.1225-1230, 1984.
DOI : 10.1056/NEJM198405103101905

R. Tierney, N. Steven, L. Young, and A. Rickinson, Epstein?Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state, J Virol, vol.68, pp.7374-7385, 1994.

R. Murray, M. Kurilla, and J. Brooks, Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies, Journal of Experimental Medicine, vol.176, issue.1, pp.157-168, 1992.
DOI : 10.1084/jem.176.1.157

R. Khanna, S. Burrows, and M. Kurilla, Localization of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: implications for vaccine development, Journal of Experimental Medicine, vol.176, issue.1, pp.169-176, 1992.
DOI : 10.1084/jem.176.1.169

L. Tan, N. Gudgeon, and N. Annels, A re-evaluation of the frequency of CD8 + T cells specific for EBV in healthy virus carriers, J Immunol, vol.162, pp.1827-1835, 1999.

C. Bogedain, H. Wolf, S. Modrow, G. Stuber, and W. Jilg, Specific cytotoxic T lymphocytes recognise the immediate-early transactivator Zta of Epstein?Barr virus, J Virol, vol.69, pp.4872-4879, 1995.

N. Steven, N. Annels, and A. Kumar, Immediate Early and Early Lytic Cycle Proteins Are Frequent Targets of the Epstein-Barr Virus???induced Cytotoxic T Cell Response, The Journal of Experimental Medicine, vol.35, issue.9, pp.1605-1617, 1997.
DOI : 10.1038/383720a0

M. Callan, L. Tan, and N. Annels, T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo, The Journal of Experimental Medicine, vol.150, issue.9, pp.1395-1402, 1998.
DOI : 10.1084/jem.186.9.1407

M. Catalano, D. Carson, S. Slovin, D. Richman, and J. Vaughan, Antibodies to Epstein-Barr virus-determined antigens in normal subjects and in patients with seropositive rheumatoid arthritis., Proceedings of the National Academy of Sciences, vol.76, issue.11, pp.5825-5828, 1979.
DOI : 10.1073/pnas.76.11.5825

Q. Yao, A. Rickinson, J. Gaston, and M. Epstein, Disturbance of the Epstein?Barr virus-host balance in rheumatoid arthritis patients: a quantitative study, Clin Exp Immunol, vol.64, pp.302-310, 1986.

C. Baboonian, P. Venables, D. Williams, R. Williams, and R. Maini, Cross reaction of antibodies to a glycine/alanine repeat sequence of Epstein-Barr virus nuclear antigen-1 with collagen, cytokeratin, and actin., Annals of the Rheumatic Diseases, vol.50, issue.11, pp.772-775, 1991.
DOI : 10.1136/ard.50.11.772

E. Scotet, J. David-ameline, and M. Peyrat, T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis, Journal of Experimental Medicine, vol.184, issue.5, pp.1791-1800, 1996.
DOI : 10.1084/jem.184.5.1791

J. David-ameline, A. Lim, and F. Davodeau, Selection of T cells reactive against autologous B lymphoblastoid cells during chronic rheumatoid arthritis, J Immunol, vol.157, pp.4697-4706, 1996.

E. Scotet, M. Peyrat, and X. Saulquin, Frequent enrichment for CD8 T cells reactive against common herpes viruses in chronic inflammatory lesions: towards a reassessment of the physiopathological significance of T cell clonal expansions found in autoimmune inflammatory processes, European Journal of Immunology, vol.95, issue.3, pp.973-985, 1999.
DOI : 10.1002/(SICI)1521-4141(199903)29:03<973::AID-IMMU973>3.0.CO;2-P

J. Altman, P. Moss, and P. Goulder, Phenotypic Analysis of Antigen-Specific T Lymphocytes, Science, vol.336, issue.6198, pp.94-96, 1996.
DOI : 10.1084/jem.183.4.1367

M. Wills, A. Carmichael, and K. Mynard, The human cytotoxic Tlymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL, J Virol, vol.70, pp.7569-7579, 1996.

J. Morrison, E. J. Latron, and F. , Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA-A2 in its recognition by cytotoxic T lymphocytes, European Journal of Immunology, vol.88, issue.4, pp.903-907, 1992.
DOI : 10.1002/eji.1830220404

M. Bunce, O. Neil, C. Barnardo, and M. , Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP), Tissue Antigens, vol.44, issue.5, pp.355-367, 1995.
DOI : 10.1111/j.1399-0039.1995.tb03127.x

S. Burrows, S. Rodda, A. Suhrbier, H. Geysen, and D. Moss, The specificity of recognition of a cytotoxic T lymphocyte epitope, European Journal of Immunology, vol.1, issue.1, pp.191-195, 1992.
DOI : 10.1002/eji.1830220128

F. Iannone, V. Corrigall, G. Kingsley, and G. Panayi, Evidence for the continuous recruitment and activation of T cells into the joints of patients with rheumatoid arthritis, European Journal of Immunology, vol.149, issue.11, pp.2706-2713, 1994.
DOI : 10.1002/eji.1830241120

O. Spertini, F. Luscinskas, and G. Kansas, Leukocyte adhesion molecule (LAM-1, L selectin) interacts with an inducible endothelial cell ligand to support leucocyte adhesion, J Immunol, vol.147, pp.2565-2573, 1991.

A. Akbar, L. Terry, A. Timms, P. Beverley, and G. Janossy, Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells, J Immunol, vol.140, pp.2171-2178, 1988.

D. Angeac, A. Monier, S. Pilling, and D. , CD57+ T lymphocytes are derived from CD57??? precursors by differentiation occurring in late immune responses, European Journal of Immunology, vol.13, issue.7, pp.1503-1511, 1994.
DOI : 10.1002/eji.1830240707

M. Azuma, J. Phillips, and L. Lanier, Antigenic and functional properties, J Immunol, vol.150, pp.28-1147, 1993.

S. Qin, J. Rottman, and P. Myers, The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions., Journal of Clinical Investigation, vol.101, issue.4, pp.746-754, 1998.
DOI : 10.1172/JCI1422

R. Bonecchi, G. Bianchi, and P. Bordignon, Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s, The Journal of Experimental Medicine, vol.158, issue.1, pp.129-134, 1998.
DOI : 10.1172/JCI119475

T. Issekutz, Lymphocyte homing to sites of inflammation, Current Opinion in Immunology, vol.4, issue.3, pp.287-293, 1992.
DOI : 10.1016/0952-7915(92)90078-S

A. Yokota, N. Murata, and O. Saiki, High avidity state of leukocyte function-associated antigen-1 on rheumatoid synovial fluid T lymphocytes, J Immunol, vol.155, pp.4118-4124, 1995.

M. Dustin and T. Springer, Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells, The Journal of Cell Biology, vol.107, issue.1, pp.321-331, 1988.
DOI : 10.1083/jcb.107.1.321

H. Einsele, M. Steidle, and C. Muller, Demonstration of cytomegalovirus (CMV) DNA and anti-CMV response in the synovial membranes and serum of patients with rheumatoid arthritis, J Rheumatol, vol.19, pp.677-681, 1992.

P. Brousset, M. Caulier, and A. Cantagrel, Absence of Epstein-Barr virus carrying cells in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis., Annals of the Rheumatic Diseases, vol.52, issue.8, pp.608-609, 1993.
DOI : 10.1136/ard.52.8.608

L. Zhang, S. Nikkari, and M. Skurnik, Detection of herpesviruses by polymerase chain reaction in lymphocytes from patients with rheumatoid arthritis, Arthritis & Rheumatism, vol.265, issue.8, pp.1080-1086, 1993.
DOI : 10.1002/art.1780360808

M. Mousavi-jazi, L. Bostrom, and C. Lovmark, Infrequent detection of cytomegalovirus and Epstein-Barr virus DNA in synovial membrance of patients with rheumatoid arthritis, J Rheumatol, vol.25, pp.623-628, 1998.

M. Takei, K. Mitamura, and S. Fujiwara, Detection of Epstein-Barr virus-encoded small RNA 1 and latent membrane protein 1 in synovial lining cells from rheumatoid arthritis patients, International Immunology, vol.9, issue.5, pp.739-743, 1997.
DOI : 10.1093/intimm/9.5.739

J. Koide, K. Takada, and M. Sugiura, Spontaneous establishment of an Epstein?Barr virus-infected fibroblast line from the synovial tissue of a rheumatoid arthritis patient, J Virol, vol.71, pp.2478-2481, 1997.

J. Edinger, M. Bonneville, and E. Scotet, EBV gene expression not altered in rheumatoid synovia despite the presence of EBV antigen-specific T cell clones, J Immunol, vol.162, pp.3694-3701, 1999.

M. Albert, B. Sauter, and N. Bhardwaj, Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs, Nature, vol.392, issue.6671, pp.86-89, 1998.
DOI : 10.1038/32183

I. Misko, S. Cross, and R. Khanna, Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: Implications for molecular mimicry in autoimmune disease, Proceedings of the National Academy of Sciences, vol.240, issue.7, pp.2279-2284, 1999.
DOI : 10.1007/BF00867354

D. Pilling, A. Akbar, and J. Girdlestone, Interferon-?? mediates stromal cell rescue of T cells from apoptosis, European Journal of Immunology, vol.26, issue.3, pp.1041-1050154, 1999.
DOI : 10.1002/(SICI)1521-4141(199903)29:03<1041::AID-IMMU1041>3.0.CO;2-#

P. Klimiuk, H. Yang, J. Goronzy, and C. Weyand, Production of Cytokines and Metalloproteinases in Rheumatoid Synovitis Is T Cell Dependent, Clinical Immunology, vol.90, issue.1, pp.65-78, 1999.
DOI : 10.1006/clim.1998.4618

M. Sebbag, S. Parry, F. Brennan, and M. Feldmann, Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-??, but not interleukin-10: Possible relevance to pathophysiology of rheumatoid arthritis, European Journal of Immunology, vol.30, issue.3, pp.624-632, 1997.
DOI : 10.1002/eji.1830270308

X. Paliard, S. West, and J. Lafferty, Evidence for the effects of a superantigen in rheumatoid arthritis, Science, vol.253, issue.5017, pp.325-329, 1991.
DOI : 10.1126/science.1857971

C. Linda, C. Tan, T. Fazou, R. Rostron, . Dunbar et al., Authors, MRC Human Immunology Unit, Institute of Molecular Medicine John Radcliffe Hospital

M. Peyrat, E. Houssaint, and M. Bonneville, ) and Alan B Rickinson (Cancer Research Campaign Institute for Cancer Studies, INSERM U643 Institute Biologie