Z. Weihua, S. Andersson, G. Cheng, E. Simpson, M. Warner et al., Update on estrogen signaling, FEBS Letters, vol.62, issue.1, pp.17-24, 2003.
DOI : 10.1016/S0014-5793(03)00436-8

P. Webb, P. Nguyen, C. Valentine, G. Lopez, G. Kwok et al., The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions, Molecular Endocrinology, vol.13, issue.10, pp.1672-1685, 1999.
DOI : 10.1210/mend.13.10.0357

S. Cowley, S. Hoare, S. Mosselman, and M. Parker, Estrogen Receptors ?? and ?? Form Heterodimers on DNA, Journal of Biological Chemistry, vol.272, issue.32, pp.19858-19862, 1997.
DOI : 10.1074/jbc.272.32.19858

S. Ogawa, S. Inoue, T. Watanabe, H. Hiroi, A. Orimo et al., The Complete Primary Structure of Human Estrogen Receptor ?? (hER??) and Its Heterodimerization with ER ??in Vivoandin Vitro, Biochemical and Biophysical Research Communications, vol.243, issue.1, pp.122-126, 1998.
DOI : 10.1006/bbrc.1997.7893

K. Pettersson, K. Grandien, G. Kuiper, and J. Gustafsson, Mouse estrogen receptor beta forms estrogen response elementbinding heterodimers with estrogen receptor alpha, Mol Endocrinol, vol.11, pp.1486-1496, 1997.

R. Reiter, A. Oh, A. Wellstein, and A. Riegel, Impact of the nuclear receptor coactivator AIB1 isoform AIB1-??3 on estrogenic ligands with different intrinsic activity, Oncogene, vol.23, issue.2, pp.403-409, 2004.
DOI : 10.1038/sj.onc.1207202

Y. Shang and M. Brown, Molecular Determinants for the Tissue Specificity of SERMs, Science, vol.295, issue.5564, pp.2465-2468, 2002.
DOI : 10.1126/science.1068537

C. Osborne, V. Bardou, T. Hopp, G. Chamness, S. Hilsenbeck et al., Role of the Estrogen Receptor Coactivator AIB1 (SRC-3) and HER-2/neu in Tamoxifen Resistance in Breast Cancer, JNCI Journal of the National Cancer Institute, vol.95, issue.5, pp.353-361, 2003.
DOI : 10.1093/jnci/95.5.353

G. Castoria, M. Barone, D. Domenico, M. Bilancio, A. Ametrano et al., Non-transcriptional action of oestradiol and progestin triggers DNA synthesis, The EMBO Journal, vol.18, issue.9, pp.2500-2510, 1999.
DOI : 10.1093/emboj/18.9.2500

E. Lobenhofer, G. Huper, J. Iglehart, and J. Marks, Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3- kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis, Cell Growth Differ, vol.11, pp.99-110, 2000.

C. Wong, C. Mcnally, E. Nickbarg, B. Komm, and B. Cheskis, Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade, Proceedings of the National Academy of Sciences, vol.8, issue.2, pp.14783-14788, 2002.
DOI : 10.1016/S1097-2765(01)00304-5

M. Razandi, A. G. Pedram, A. Ghonshani, S. Webb, P. Levin et al., Identification of a Structural Determinant Necessary for the Localization and Function of Estrogen Receptor ?? at the Plasma Membrane, Molecular and Cellular Biology, vol.23, issue.5, pp.1633-1646, 2003.
DOI : 10.1128/MCB.23.5.1633-1646.2003

F. Barletta, C. Wong, C. Mcnally, B. Komm, B. Katzenellenbogen et al., Characterization of the Interactions of Estrogen Receptor and MNAR in the Activation of cSrc, Molecular Endocrinology, vol.18, issue.5, pp.1096-1108, 2004.
DOI : 10.1210/me.2003-0335

A. Migliaccio, M. Domenico, G. Castoria, D. Falco, A. Bontempo et al., Tyrosine kinase/p21ras/MAP kinase pathway activation by estradiol-receptor complex in MCF-7 cells, EMBO J, vol.15, pp.1292-1300, 1996.

A. Migliaccio, G. Castoria, D. Domenico, M. De-falco, A. Bilancio et al., Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation, The EMBO Journal, vol.19, issue.20, pp.5406-5417, 2000.
DOI : 10.1093/emboj/19.20.5406

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC314017

F. Zhang and P. Casey, Protein Prenylation: Molecular Mechanisms and Functional Consequences, Annual Review of Biochemistry, vol.65, issue.1, pp.241-269, 1996.
DOI : 10.1146/annurev.bi.65.070196.001325

S. Doisneau-sixou, P. Cestac, S. Chouini, J. Carroll, A. Hamilton et al., Contrasting Effects of Prenyltransferase Inhibitors on Estrogen-Dependent Cell Cycle Progression and Estrogen Receptor-Mediated Transcriptional Activity in MCF-7 Cells, Endocrinology, vol.144, issue.3, pp.989-998, 2003.
DOI : 10.1210/en.2002-220726

URL : https://hal.archives-ouvertes.fr/inserm-00090777

D. Robyr, A. Wolffe, and W. Wahli, Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared Tasks, Molecular Endocrinology, vol.14, issue.3, pp.329-347, 2000.
DOI : 10.1210/mend.14.3.0411

P. Balaguer, A. Boussioux, E. Demirpence, and J. Nicolas, Reporter cell lines are useful tools for monitoring biological activity of nuclear receptor ligands, Luminescence, vol.14, issue.2, pp.153-158, 2001.
DOI : 10.1002/bio.630

V. Kumar, S. Green, A. Staub, and P. Chambon, Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor, EMBO J, vol.5, pp.2231-2236, 1986.

S. Dillon and L. Feig, [20] Purification and assay of recombinant C3 transferase, Methods Enzymol, vol.256, pp.174-184, 1995.
DOI : 10.1016/0076-6879(95)56022-X

D. Gagne, P. Balaguer, E. Demirpence, C. Chabret, F. Trousse et al., Stable luciferase transfected cells for studying steroid receptor biological activity, Journal of Bioluminescence and Chemiluminescence, vol.5, issue.3, pp.201-209, 1994.
DOI : 10.1002/bio.1170090314

S. Doisneau-sixou, P. Cestac, J. Faye, G. Favre, and R. Sutherland, Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression, International Journal of Cancer, vol.10, issue.5, pp.789-798, 2003.
DOI : 10.1002/ijc.11263

L. Su, R. Knoblauch, and M. Garabedian, Rho GTPases as Modulators of the Estrogen Receptor Transcriptional Response, Journal of Biological Chemistry, vol.276, issue.5, pp.3231-3237, 2001.
DOI : 10.1074/jbc.M005547200

L. Su, Z. Wang, and M. Garabedian, Regulation of GRIP1 and CBP Coactivator Activity by Rho GDI Modulates Estrogen Receptor Transcriptional Enhancement, Journal of Biological Chemistry, vol.277, issue.40, pp.37037-37044, 2002.
DOI : 10.1074/jbc.M111607200

M. Gaub, M. Bellard, I. Scheuer, P. Chambon, and P. Sassone-corsi, Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex, Cell, vol.63, issue.6, pp.1267-1276, 1990.
DOI : 10.1016/0092-8674(90)90422-B

Y. Umayahara, R. Kawamori, H. Watada, E. Imano, N. Iwama et al., Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer, J Biol Chem, vol.269, pp.16433-16442, 1994.

K. Paech, P. Webb, G. Kuiper, S. Nilsson, J. Gustafsson et al., Differential Ligand Activation of Estrogen Receptors ER and ER at AP1 Sites, Science, vol.277, issue.5331, pp.1508-1510, 1997.
DOI : 10.1126/science.277.5331.1508

M. Liu, C. Albanese, C. Anderson, K. Hilty, P. Webb et al., Opposing Action of Estrogen Receptors ?? and ?? on Cyclin D1 Gene Expression, Journal of Biological Chemistry, vol.277, issue.27, pp.24353-24360, 2002.
DOI : 10.1074/jbc.M201829200

J. Adnane, E. Seijo, Z. Chen, F. Bizouarn, M. Leal et al., RhoB, Not RhoA, Represses the Transcription of the Transforming Growth Factor ?? Type II Receptor by a Mechanism Involving Activator Protein 1, Journal of Biological Chemistry, vol.277, issue.10, pp.8500-8507, 2002.
DOI : 10.1074/jbc.M104367200

C. Hill, J. Wynne, and R. Treisman, The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF, Cell, vol.81, issue.7, pp.1159-1170, 1995.
DOI : 10.1016/S0092-8674(05)80020-0

P. Lebowitz, W. Du, and G. Prendergast, Prenylation of RhoB Is Required for Its Cell Transforming Function but Not Its Ability to Activate Serum Response Element-dependent Transcription, Journal of Biological Chemistry, vol.272, issue.26, pp.16093-16095, 1997.
DOI : 10.1074/jbc.272.26.16093

C. Allal, G. Favre, B. Couderc, S. Salicio, S. Sixou et al., RhoA Prenylation Is Required for Promotion of Cell Growth and Transformation and Cytoskeleton Organization but Not for Induction of Serum Response Element Transcription, Journal of Biological Chemistry, vol.275, issue.40, pp.31001-31008, 2000.
DOI : 10.1074/jbc.M005264200

G. Fritz and B. Kaina, Ras-related GTPase RhoB Represses NF-??B Signaling, Journal of Biological Chemistry, vol.276, issue.5, pp.3115-3122, 2001.
DOI : 10.1074/jbc.M005058200

M. Razandi, P. Oh, A. Pedram, J. Schnitzer, and E. Levin, ERs Associate with and Regulate the Production of Caveolin: Implications for Signaling and Cellular Actions, Molecular Endocrinology, vol.16, issue.1, pp.100-115, 2002.
DOI : 10.1210/mend.16.1.0757

P. Michaely, C. Mineo, Y. Ying, and R. Anderson, Polarized Distribution of Endogenous Rac1 and RhoA at the Cell Surface, Journal of Biological Chemistry, vol.274, issue.30, pp.21430-21436, 1999.
DOI : 10.1074/jbc.274.30.21430

M. Yamaga, M. Sekimata, M. Fujii, K. Kawai, H. Kamata et al., A PLCdelta1-binding protein, p122/RhoGAP, is localized in caveolin-enriched membrane domains and regulates caveolin internalization, Genes to Cells, vol.58, issue.1, pp.25-37, 2004.
DOI : 10.1038/sj.onc.1206064

C. Giamarchi, C. Chailleux, M. Callige, P. Rochaix, D. Trouche et al., Two antiestrogens affect differently chromatin remodeling of trefoil factor 1 (pS2) gene and the fate of estrogen receptor in MCF7 cells, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol.1578, issue.1-3, pp.12-20, 2002.
DOI : 10.1016/S0167-4781(02)00480-3

P. Maruvada, C. Baumann, G. Hager, and P. Yen, Dynamic Shuttling and Intranuclear Mobility of Nuclear Hormone Receptors, Journal of Biological Chemistry, vol.278, issue.14, pp.12425-12432, 2003.
DOI : 10.1074/jbc.M202752200

Z. Nawaz, D. Lonard, A. Dennis, C. Smith, O. Malley et al., Proteasome-dependent degradation of the human estrogen receptor, Proceedings of the National Academy of Sciences, vol.349, issue.6305, pp.1858-1862, 1999.
DOI : 10.1038/349132a0

M. Engel, P. Datta, and H. Moses, RhoB Is Stabilized by Transforming Growth Factor beta and Antagonizes Transcriptional Activation, Journal of Biological Chemistry, vol.273, issue.16, pp.9921-9926, 1998.
DOI : 10.1074/jbc.273.16.9921

M. Wherlock, A. Gampel, C. Futter, and H. Mellor, Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase, Journal of Cell Science, vol.117, issue.15, pp.3221-3231, 2004.
DOI : 10.1242/jcs.01193

D. Cremoux, P. Gauville, C. Closson, V. Linares, G. Calvo et al., EGF modulation of theras-relatedrhoB gene expression in human breast-cancer cell lines, International Journal of Cancer, vol.12, issue.3, pp.408-415, 1994.
DOI : 10.1002/ijc.2910590320

W. Du, P. Lebowitz, and G. Prendergast, Cell Growth Inhibition by Farnesyltransferase Inhibitors Is Mediated by Gain of Geranylgeranylated RhoB, Molecular and Cellular Biology, vol.19, issue.3, pp.1831-1840, 1999.
DOI : 10.1128/MCB.19.3.1831

D. Rubino, P. Driggers, D. Arbit, L. Kemp, B. Miller et al., Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action, Oncogene, vol.16, issue.19, pp.2513-2526, 1998.
DOI : 10.1038/sj.onc.1201783

A. Avots, M. Buttmann, S. Chuvpilo, C. Escher, U. Smola et al., CBP/p300 Integrates Raf/Rac-Signaling Pathways in the Transcriptional Induction of NF-ATc during T Cell Activation, Immunity, vol.10, issue.5, pp.515-524, 1999.
DOI : 10.1016/S1074-7613(00)80051-5

A. Alberts, O. Geneste, and R. Treisman, Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation, Cell, vol.92, issue.4, pp.475-487, 1998.
DOI : 10.1016/S0092-8674(00)80941-1

S. Johnston, J. Head, S. Pancholi, S. Detre, L. Martin et al., Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer, Clin Cancer Res, vol.9, pp.524-532, 2003.

S. Johnston, T. Hickish, P. Ellis, S. Houston, L. Kelland et al., Phase II Study of the Efficacy and Tolerability of Two Dosing Regimens of the Farnesyl Transferase Inhibitor, R115777, in Advanced Breast Cancer, Journal of Clinical Oncology, vol.21, issue.13, pp.2492-2499, 2003.
DOI : 10.1200/JCO.2003.10.064

S. Sebti and A. Adjei, Farnesyltransferase inhibitors, Seminars in Oncology, vol.31, pp.28-39, 2004.
DOI : 10.1053/j.seminoncol.2003.12.012