Emerging potentials for an antioxidant therapy as a new approach to the treatment of systemic sclerosis, Toxicology, vol.155, pp.1-15, 2000. ,
Increased urinary F2-isoprostanes in systemic sclerosis, but not in primary Raynaud's phenomenon: Effect of cold exposure, Arthritis & Rheumatism, vol.95, issue.5, pp.1319-1323, 2002. ,
DOI : 10.1002/art.10261
Sequential dermal microvascular and perivascular changes in the development of scleroderma, The Journal of Pathology, vol.178, issue.3, pp.255-263, 1992. ,
DOI : 10.1002/path.1711660307
Lymphocytes in the skin of patients with progressive systemic sclerosis, Arthritis & Rheumatism, vol.2, issue.6, pp.645-653, 1984. ,
DOI : 10.1002/art.1780270607
Lymphocyte interactions with the vascular endothelium in systemic sclerosis, Clinics in Dermatology, vol.12, issue.3, pp.361-367, 1994. ,
DOI : 10.1016/0738-081X(94)90288-7
Inflammation and Atherosclerosis, Circulation, vol.105, issue.9, pp.1135-1143, 2002. ,
DOI : 10.1161/hc0902.104353
Monocytes of Patients with Systemic Sclerosis (Scleroderma) Spontaneously Release In Vitro Increased Amounts of Superoxide Anion, Journal of Investigative Dermatology, vol.112, issue.1, pp.78-84, 1999. ,
DOI : 10.1046/j.1523-1747.1999.00476.x
Antioxidant effects of calcium channel blockers against free radical injury in endothelial cells. Correlation of protection with preservation of glutathione levels, Circulation Research, vol.70, issue.6, pp.1099-1103, 1992. ,
DOI : 10.1161/01.RES.70.6.1099
Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide, Pharmacol Res, vol.45, pp.27-33, 2002. ,
Acute and sustained effects of dihydropyridine-type calcium channel antagonists on oxidative stress in systemic sclerosis, The American Journal of Medicine, vol.116, issue.9, pp.595-600, 2004. ,
DOI : 10.1016/j.amjmed.2003.11.022
Nifedipine decreases s-VCAM-1 concentrations and oxidative stress in systemic sclerosis, but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1, Arthritis Research & Therapy, vol.6, issue.4, pp.309-314, 2004. ,
DOI : 10.1186/ar1183
Scleroderma (systemic sclerosis): classification, subsets and pathogenesis, J Rheumatol, vol.15, pp.202-205, 1988. ,
Conclusion and identification of the core set of variables to be used in clinical investigations, Clin Exp Rheumatol, vol.21, issue.3, pp.47-48, 2003. ,
Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system., Journal of Clinical Investigation, vol.61, issue.4, pp.1081-1087, 1978. ,
DOI : 10.1172/JCI109007
Substance P primes human neutrophil activation: A mechanism for neurological regulation of inflammation, Biochemical and Biophysical Research Communications, vol.161, issue.2, pp.520-524, 1989. ,
DOI : 10.1016/0006-291X(89)92630-2
Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine, Blood, vol.82, pp.2890-2898, 1993. ,
A radical proposal for the pathogenesis of scleroderma, Journal of the American Academy of Dermatology, vol.28, issue.1, pp.78-85, 1993. ,
DOI : 10.1016/0190-9622(93)70014-K
Oxidative stress in scleroderma: Maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway, Arthritis & Rheumatism, vol.92, issue.11, pp.2653-2664, 2001. ,
DOI : 10.1002/1529-0131(200111)44:11<2653::AID-ART445>3.0.CO;2-1
Assembly and regulation of NADPH oxidase and nitric oxide synthase, Current Opinion in Immunology, vol.6, issue.1, pp.131-139, 1994. ,
DOI : 10.1016/0952-7915(94)90044-2
Calcium-channel blockers for Raynaud's phenomenon in systemic sclerosis, Arthritis & Rheumatism, vol.242, issue.8, pp.1841-1847, 2001. ,
DOI : 10.1002/1529-0131(200108)44:8<1841::AID-ART322>3.0.CO;2-8
The effect of nifedipine on myocardial perfusion and metabolism in systemic sclerosis. A positron emission tomographic study, Arthritis & Rheumatism, vol.5, issue.2, pp.198-203, 1991. ,
DOI : 10.1002/art.1780340211
1,4-Dihydropyridine Calcium Channel Blockers Inhibit Plasma and LDL Oxidation and Formation of Oxidation-Specific Epitopes in the Arterial Wall and Prolong Survival in Stroke-Prone Spontaneously Hypertensive Rats ?? Editorial Comment, Stroke, vol.30, issue.9, pp.1907-1915, 1999. ,
DOI : 10.1161/01.STR.30.9.1907
Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients, Journal of Hypertension, vol.19, issue.8, pp.1379-1386, 2001. ,
DOI : 10.1097/00004872-200108000-00005
Calcium Antagonists Ameliorate Ischemia-Induced Endothelial Cell Permeability by Inhibiting Protein Kinase C, Circulation, vol.99, issue.19, pp.2523-2529, 1999. ,
DOI : 10.1161/01.CIR.99.19.2523
Antioxidant effects and anti-elastase activity of the calcium antagonist nicardipine on activated human and rabbit neutrophils ? a potential antiatherosclerotic property of calcium antagonists? Cardiovasc Drugs Ther, pp.515-520, 2002. ,
Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells., Proceedings of the National Academy of Sciences, vol.86, issue.7, pp.2388-2392, 1989. ,
DOI : 10.1073/pnas.86.7.2388
Syntheses and calcium channel antagonist activity of nifedipine analogues with methylsulfonylimidazolyl substituent, Pharmaceutica Acta Helvetiae, vol.73, issue.2, pp.75-79, 1998. ,
DOI : 10.1016/S0031-6865(98)00004-1
Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids, Cardiovascular Research, vol.42, issue.3, pp.752-760, 1999. ,
DOI : 10.1016/S0008-6363(98)00341-1
Interaction of 1,4 dihydropyridine calcium channel antagonists with biological membranes: Lipid bilayer partitioning could occur before drug binding to receptors, Journal of Molecular and Cellular Cardiology, vol.21, issue.2, pp.187-201, 1989. ,
DOI : 10.1016/0022-2828(89)90861-4
EFFECTS OF CALCIUM ANTAGONIST DILTIAZEM ON LEUKOCYTE ELASTASE AND ON REACTIVE OXYGEN SPECIES PRODUCTION IN HUMAN NEUTROPHILS, Pharmacological Research, vol.33, issue.2, pp.117-122, 1996. ,
DOI : 10.1006/phrs.1996.0017
Intracellular calcium, currents, and stimulus-response coupling in endothelial cells, Hypertension, vol.21, issue.1, pp.112-127, 1993. ,
DOI : 10.1161/01.HYP.21.1.112