Skip to Main content Skip to Navigation
Journal articles

clc is co-expressed with clf or cntfr in developing mouse muscles.

Abstract : BACKGROUND: The ciliary neurotrophic factor (CNTF) receptor is composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor, associated with a non-signalling CNTF binding receptor alpha component (CNTFR). This tripartite receptor has been shown to play important roles in the development of motor neurons, but the identity of the relevant ligand(s) is still not clearly established. Recently, we have identified two new ligands for the CNTF receptor complex. These are heterodimeric cytokines composed of cardiotrophin-like cytokine (CLC) associated either with the soluble receptor subunit cytokine-like factor-1 (CLF) or the soluble form of the binding receptor itself (sCNTFR). RESULTS: Here we show that, during development, clc is expressed in lung, kidney, vibrissae, tooth, epithelia and muscles during the period of development corresponding to when motoneuron loss is observed in mice lacking a functional CNTF receptor. In addition, we demonstrate that it is co-expressed at the single cell level with clf and cntfr, supporting the idea that CLC might be co-secreted with either CLF or sCNTFR. CONCLUSION: This expression pattern is in favor of CLC, associated either with CLF or sCNTFR, being an important player in the signal triggered by the CNTF receptor being required for motoneuron development.
Complete list of metadata

Cited literature [9 references]  Display  Hide  Download
Contributor : Françoise Maylin <>
Submitted on : Thursday, September 14, 2006 - 1:51:43 PM
Last modification on : Monday, July 20, 2020 - 12:34:51 PM
Long-term archiving on: : Thursday, September 20, 2012 - 10:35:18 AM




Béatrice de Bovis, Damien Derouet, Jean-François Gauchat, Greg Elson, Hugues Gascan, et al.. clc is co-expressed with clf or cntfr in developing mouse muscles.. Cell Commun Signal, 2005, 3, pp.1. ⟨10.1186/1478-811X-3-1⟩. ⟨inserm-00093960⟩



Record views


Files downloads