A. Fire, S. Xu, M. Montgomery, K. S. Driver, S. Mello et al., Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, Nature, issue.6669, pp.391806-391817, 1998.

A. Hamilton and D. Baulcombe, A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants, Science, vol.286, issue.5441, pp.950-952, 1999.
DOI : 10.1126/science.286.5441.950

E. Bernstein, A. Caudy, S. Hammond, and G. Hannon, Role for a bidentate ribonuclease in the initiation step of RNA interference, Nature, vol.409, issue.6818, pp.363-369, 2001.
DOI : 10.1038/35053110

P. Zamore, T. Tuschl, P. Sharp, and D. Bartel, RNAi, Cell, vol.101, issue.1, pp.25-33, 2000.
DOI : 10.1016/S0092-8674(00)80620-0

A. Nykanen, B. Haley, and P. Zamore, ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway, Cell, vol.107, issue.3, pp.309-330, 2001.
DOI : 10.1016/S0092-8674(01)00547-5

D. Schwarz, G. Hutvagner, B. Haley, and P. Zamore, Evidence that siRNAs Function as Guides, Not Primers, in the Drosophila and Human RNAi Pathways, Molecular Cell, vol.10, issue.3, pp.537-585, 2002.
DOI : 10.1016/S1097-2765(02)00651-2

C. Napoli, C. Lemieux, R. Jorgensen, L. Mur, M. Beld et al., Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans, THE PLANT CELL ONLINE, vol.2, issue.4, pp.279-289291, 1990.
DOI : 10.1105/tpc.2.4.279

C. Cogoni, J. Irelan, M. Schumacher, T. Schmidhauser, E. Selker et al., Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation, EMBO J, issue.12, pp.153153-63, 1996.

F. Ruiz, L. Vayssie, C. Klotz, L. Sperling, and L. Madeddu, Homology-dependent Gene Silencing in Paramecium, Molecular Biology of the Cell, vol.9, issue.4, pp.931-974, 1998.
DOI : 10.1091/mbc.9.4.931

J. Kennerdell and R. Carthew, Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway, Cell, vol.95, issue.7, pp.951017-951043, 1998.
DOI : 10.1016/S0092-8674(00)81725-0

L. Misquitta and B. Paterson, Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation, Proceedings of the National Academy of Sciences, vol.95, issue.7, pp.1451-1457, 1999.
DOI : 10.1016/S0092-8674(00)81725-0

P. Bastin, T. Sherwin, and K. Gull, Paraflagellar rod is vital for trypanosome motility, Nature, vol.391, issue.6667, p.548, 1998.
DOI : 10.1038/35300

H. Ngô, C. Tschudi, K. Gull, and E. Ullu, Double-stranded RNA induces mRNA degradation in Trypanosoma brucei, Proceedings of the National Academy of Sciences, vol.88, issue.22, pp.9514687-92, 1998.
DOI : 10.1073/pnas.88.22.10074

F. Wianny and M. Zernicka-goetz, Specific interference with gene function by double-stranded RNA in early mouse development, Nature Cell Biology, vol.126, issue.2, pp.70-75, 2000.
DOI : 10.1101/GAD.13.22.3015

S. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber et al., Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells, Nature, issue.6836, pp.411494-411502, 2001.

P. Mourrain, C. Beclin, T. Elmayan, F. Feuerbach, C. Godon et al., Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance, Cell, vol.101, issue.5, pp.533-575, 2000.
DOI : 10.1016/S0092-8674(00)80863-6
URL : http://doi.org/10.1016/s0092-8674(00)80863-6

T. Dalmay, A. Hamilton, S. Rudd, S. Angell, and D. Baulcombe, An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus, Cell, vol.101, issue.5, pp.543-53, 2000.
DOI : 10.1016/S0092-8674(00)80864-8

H. Tabara, M. Sarkissian, W. Kelly, J. Fleenor, A. Grishok et al., The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans, Cell, vol.99, issue.2, pp.123-155, 1999.
DOI : 10.1016/S0092-8674(00)81644-X

R. Ketting, T. Haverkamp, H. Van-luenen, and R. Plasterk, mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD, Cell, vol.99, issue.2, pp.133-174, 1999.
DOI : 10.1016/S0092-8674(00)81645-1

T. Sijen and R. Plasterk, Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi, Nature, vol.426, issue.6964, pp.310-314, 2003.
DOI : 10.1038/nature02107

A. Fraser, R. Kamath, P. Zipperlen, M. Martinez-campos, M. Sohrmann et al., Functional genomic analysis of C. elegans chromosome I by systematic RNA interference, Nature, vol.408, issue.6810, pp.325-355, 2000.

P. Gonczy, C. Echeverri, K. Oegema, A. Coulson, S. Jones et al., Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III, Nature, issue.6810, pp.408331-408337, 2000.

J. Morris, Z. Wang, M. Drew, and P. Englund, Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library, The EMBO Journal, vol.21, issue.17, pp.4429-4467, 2002.
DOI : 10.1093/emboj/cdf474
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125414

A. Kiger, B. Baum, S. Jones, M. Jones, A. Coulson et al., A functional genomic analysis of cell morphology using RNA interference, Journal of Biology, vol.2, issue.4, p.27, 2003.
DOI : 10.1186/1475-4924-2-27

R. Kamath, A. Fraser, Y. Dong, G. Poulin, R. Durbin et al., Systematic functional analysis of the Caenorhabditis elegans genome using RNAi, Nature, vol.421, issue.6920, pp.421231-421238, 2003.
DOI : 10.1038/nature01278

P. Paddison, A. Caudy, E. Bernstein, G. Hannon, and D. Conklin, Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells, Genes & Development, vol.16, issue.8, pp.948-58, 2002.
DOI : 10.1101/gad.981002
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152352

P. Svoboda, P. Stein, and R. Schultz, RNAi in Mouse Oocytes and Preimplantation Embryos: Effectiveness of Hairpin dsRNA, Biochemical and Biophysical Research Communications, vol.287, issue.5, pp.1099-104, 2001.
DOI : 10.1006/bbrc.2001.5707

G. Stark, I. Kerr, B. Williams, R. Silverman, and R. Schreiber, HOW CELLS RESPOND TO INTERFERONS, Annual Review of Biochemistry, vol.67, issue.1, pp.227-64, 1998.
DOI : 10.1146/annurev.biochem.67.1.227

J. Yu, S. Deruiter, and D. Turner, RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells, Proceedings of the National Academy of Sciences, vol.171, issue.2, pp.6047-52, 2002.
DOI : 10.1016/0378-1119(96)00075-3

G. Sui, C. Soohoo, B. Affar-el, F. Gay, Y. Shi et al., A DNA vector-based RNAi technology to suppress gene expression in mammalian cells, Proceedings of the National Academy of Sciences, vol.69, issue.6, pp.995515-995535, 2002.
DOI : 10.1016/0092-8674(92)90611-F

M. Mcmanus and P. Sharp, Gene silencing in mammals by small interfering RNAs, Nature Reviews Genetics, vol.16, issue.10, pp.737-784, 2002.
DOI : 10.1038/nrg908

D. Dykxhoorn, C. Novina, and P. Sharp, Killing the messenger: short rnas that silence gene expression, Nature Reviews Molecular Cell Biology, vol.4, issue.6, pp.457-67, 2003.
DOI : 10.1038/nrm1129

J. Chi, H. Chang, N. Wang, D. Chang, N. Dunphy et al., Genomewide view of gene silencing by small interfering RNAs, Proceedings of the National Academy of Sciences, vol.102, issue.1, pp.6343-6349, 2003.
DOI : 10.1016/S0092-8674(00)00015-5

D. Semizarov, L. Frost, A. Sarthy, P. Kroeger, D. Halbert et al., Specificity of short interfering RNA determined through gene expression signatures, Proceedings of the National Academy of Sciences, vol.10, issue.3, pp.6347-52, 2003.
DOI : 10.1016/S1097-2765(02)00651-2

A. Jackson, S. Bartz, J. Schelter, S. Kobayashi, J. Burchard et al., Expression profiling reveals off-target gene regulation by RNAi, Nature Biotechnology, vol.21, issue.6, pp.635-642, 2003.
DOI : 10.1038/nbt831

P. Scacheri, O. Rozenblatt-rosen, N. Caplen, T. Wolfsberg, L. Umayam et al., Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells, Proceedings of the National Academy of Sciences, vol.101, issue.7, pp.1892-1899, 2004.
DOI : 10.1073/pnas.1630797100

C. Clayton, T. Hausler, and J. Blattner, Protein trafficking in kinetoplastid protozoa, Microbiol Rev, vol.59, issue.3, pp.325-369, 1995.

K. Gull, The Cytoskeleton of Trypanosomatid Parasites, Annual Review of Microbiology, vol.53, issue.1, pp.629-55, 1999.
DOI : 10.1146/annurev.micro.53.1.629

L. Vanhamme and E. Pays, Control of gene expression in trypanosomes, Microbiol Rev, vol.59, issue.2, pp.223-263, 1995.

P. Bastin, K. Ellis, L. Kohl, and K. Gull, Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system, J Cell Sci, vol.113, pp.3321-3329, 2000.

D. Lacount, S. Bruse, K. Hill, and J. Donelson, Double-stranded RNA interference in Trypanosoma brucei using head-to-head promoters, Molecular and Biochemical Parasitology, vol.111, issue.1, pp.67-76, 2000.
DOI : 10.1016/S0166-6851(00)00300-5

Z. Wang, J. Morris, M. Drew, and P. Englund, Inhibition of Trypanosoma brucei Gene Expression by RNA Interference Using an Integratable Vector with Opposing T7 Promoters, Journal of Biological Chemistry, vol.275, issue.51, pp.27540174-27540183, 2000.
DOI : 10.1074/jbc.M008405200

L. Kohl, D. Robinson, and P. Bastin, Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes, The EMBO Journal, vol.22, issue.20, pp.5336-5382, 2003.
DOI : 10.1093/emboj/cdg518
URL : https://hal.archives-ouvertes.fr/hal-00108210

P. Bastin, K. Matthews, and K. Gull, The paraflagellar rod of kinetoplastida: Solved and unsolved questions, Parasitology Today, vol.12, issue.8, pp.302-307, 1996.
DOI : 10.1016/0169-4758(96)10031-4

J. Maga and J. Lebowitz, Unravelling the kinetoplastid paraflagellar rod, Trends in Cell Biology, vol.9, issue.10, pp.409-422, 1999.
DOI : 10.1016/S0962-8924(99)01635-9

M. Durand-dubief, L. Kohl, and P. Bastin, Efficiency and specificity of RNA interference generated by intra-and intermolecular