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Journal articles
Lack of association between serological evidence of past Coxiella burnetii infection and incident ischaemic heart disease: nested case-control study.
Abstract : BACKGROUND: Coxiella burnetii causes the common worldwide zoonotic infection, Q fever. It has been previously suggested that patients who had recovered from acute Q fever (whether symptomatic or otherwise) may be at increased risk of ischaemic heart disease. We undertook this study to determine if past infection with Coxiella burnetii, the aetiological agent of Q fever, is a risk factor for the subsequent development of ischaemic heart disease. METHODS: A nested case-control study within the Prospective Epidemiological Study of Myocardial Infarction (PRIME). The PRIME study is a cohort study of 10,593 middle-aged men undertaken in France and Northern Ireland in the 1990s. A total of 335 incident cases of ischaemic heart disease (IHD) were identified and each case was matched to 2 IHD free controls. Q fever seropositivity was determined using a commercial IgG ELISA method. RESULTS: Seroprevalence of Q fever in the controls from Northern Ireland and France were 7.8% and 9.0% respectively. No association was seen between seropositivity and age, smoking, lipid levels, or inflammatory markers. The unadjusted odds ratio (95% CI) for Q fever seropositivity in cases compared to controls was 0.95 (0.59, 1.57). The relationship was substantially unaltered following adjustment for cardiovascular risk factors and potential confounders. CONCLUSION: Serological evidence of past infection with C. burnetii was not found to be associated with an increased risk of IHD.
Cited literature [12 references]
https://www.hal.inserm.fr/inserm-00090261
Contributor : Françoise Maylin <>
Submitted on : Tuesday, August 29, 2006 - 3:13:44 PM
Last modification on : Sunday, October 25, 2020 - 7:06:58 AM
Long-term archiving on: : Tuesday, September 18, 2012 - 4:51:58 PM
Contributor : Françoise Maylin <>
Submitted on : Tuesday, August 29, 2006 - 3:13:44 PM
Last modification on : Sunday, October 25, 2020 - 7:06:58 AM
Long-term archiving on: : Tuesday, September 18, 2012 - 4:51:58 PM