Skip to Main content Skip to Navigation
Journal articles

Lack of association between serological evidence of past Coxiella burnetii infection and incident ischaemic heart disease: nested case-control study.

Abstract : BACKGROUND: Coxiella burnetii causes the common worldwide zoonotic infection, Q fever. It has been previously suggested that patients who had recovered from acute Q fever (whether symptomatic or otherwise) may be at increased risk of ischaemic heart disease. We undertook this study to determine if past infection with Coxiella burnetii, the aetiological agent of Q fever, is a risk factor for the subsequent development of ischaemic heart disease. METHODS: A nested case-control study within the Prospective Epidemiological Study of Myocardial Infarction (PRIME). The PRIME study is a cohort study of 10,593 middle-aged men undertaken in France and Northern Ireland in the 1990s. A total of 335 incident cases of ischaemic heart disease (IHD) were identified and each case was matched to 2 IHD free controls. Q fever seropositivity was determined using a commercial IgG ELISA method. RESULTS: Seroprevalence of Q fever in the controls from Northern Ireland and France were 7.8% and 9.0% respectively. No association was seen between seropositivity and age, smoking, lipid levels, or inflammatory markers. The unadjusted odds ratio (95% CI) for Q fever seropositivity in cases compared to controls was 0.95 (0.59, 1.57). The relationship was substantially unaltered following adjustment for cardiovascular risk factors and potential confounders. CONCLUSION: Serological evidence of past infection with C. burnetii was not found to be associated with an increased risk of IHD.
Document type :
Journal articles
Complete list of metadatas

Cited literature [12 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00090261
Contributor : Françoise Maylin <>
Submitted on : Tuesday, August 29, 2006 - 3:13:44 PM
Last modification on : Wednesday, September 16, 2020 - 4:57:35 PM
Long-term archiving on: : Tuesday, September 18, 2012 - 4:51:58 PM

Identifiers

Collections

Citation

Conall Mccaughey, Liam Murray, James Mckenna, Peter Coyle, Hugh O'Neill, et al.. Lack of association between serological evidence of past Coxiella burnetii infection and incident ischaemic heart disease: nested case-control study.. BMC Infectious Diseases, BioMed Central, 2005, 5, pp.61. ⟨10.1186/1471-2334-5-61⟩. ⟨inserm-00090261⟩

Share

Metrics

Record views

458

Files downloads

992