A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined Immunodeficiency, New England Journal of Medicine, vol.348, issue.3, pp.255-256, 2003. ,
DOI : 10.1056/NEJM200301163480314
LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1, Science, vol.302, issue.5644, pp.415-419, 2003. ,
DOI : 10.1126/science.1088547
[2-hydroxy-1- (hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication The CD20/ alphaCD20 'suicide' system: novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells, Proc Natl Acad Sci Gene Ther, vol.80, issue.13, pp.9-4139, 1983. ,
Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice, Oncogene, vol.21, issue.7, pp.1028-1037, 2002. ,
DOI : 10.1038/sj.onc.1205050
In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma, Cancer Res, vol.57, pp.4279-4284, 1997. ,
Artificial mammalian gene regulation networks???novel approaches for gene therapy and bioengineering, Journal of Biotechnology, vol.98, issue.2-3, pp.161-187, 2002. ,
DOI : 10.1016/S0168-1656(02)00130-X
Changing colors in mice: an inducible system that delivers, Genes & Development, vol.15, issue.12, pp.1461-1467, 2001. ,
DOI : 10.1101/gad.909301
Perspectives on farnesyl transferase inhibitors in cancer therapy, Cancer Letters, vol.206, issue.2, pp.159-167, 2004. ,
DOI : 10.1016/j.canlet.2003.08.033
Crystallographic Analysis of CaaX Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity, Journal of Molecular Biology, vol.343, issue.2, pp.417-433, 2004. ,
DOI : 10.1016/j.jmb.2004.08.056
Protein prenylation: a pivotal posttranslational process, Biochemical and Biophysical Research Communications, vol.303, issue.1, pp.1-7, 2003. ,
DOI : 10.1016/S0006-291X(03)00323-1
Enzymology and biology of CaaX protein prenylation, Recent Prog Horm Res, vol.54, pp.315-357, 1999. ,
RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: Evidenced in vivo by an anti-farnesyl cysteine antibody, Proceedings of the National Academy of Sciences, vol.255, issue.2, pp.11626-11631, 2000. ,
DOI : 10.1006/abbi.1993.1135
Ras signalling on the endoplasmic reticulum and the Golgi, Nature Cell Biology, vol.4, pp.343-350, 2002. ,
DOI : 10.1038/ncb783
Ras Family Signaling: Therapeutic Targeting, Cancer Biology & Therapy, vol.1, issue.6, pp.599-606, 2002. ,
DOI : 10.4161/cbt.306
Pharmacological-based translational induction of transgene expression in mammalian cells, EMBO reports, vol.5, issue.7, pp.721-727, 2004. ,
DOI : 10.1146/ANNUREV.BIOCHEM.65.1.241
Targeting gene expression to tumor cells with loss of wild-type p53 function, Cancer Gene Therapy, vol.7, issue.1, pp.4-12, 2000. ,
DOI : 10.1038/sj.cgt.7700091
A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced Phosphorylation, Science, vol.292, issue.5523, pp.1910-1915, 2001. ,
DOI : 10.1126/science.1058637
Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells, Cell, vol.71, issue.4, pp.543-546, 1992. ,
DOI : 10.1016/0092-8674(92)90586-2
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6, Nature, vol.352, issue.6333, pp.345-347, 1991. ,
DOI : 10.1038/352345a0
, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane, The Journal of Cell Biology, vol.20, issue.2, pp.235-246, 2002. ,
DOI : 10.1016/S1097-2765(01)00213-1
Induction of apoptosis and G2/M arrest by infection with replication-deficient adenovirus at high multiplicity of infection, Gene Therapy, vol.6, issue.6, pp.1054-1063, 1999. ,
DOI : 10.1038/sj.gt.3300914
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models, Cancer Res, vol.61, pp.8758-8768, 2001. ,
p53 Has a Direct Apoptogenic Role at the Mitochondria, Molecular Cell, vol.11, issue.3, pp.53577-590, 2003. ,
DOI : 10.1016/S1097-2765(03)00050-9
p53 in signaling checkpoint arrest or apoptosis, Current Opinion in Genetics & Development, vol.6, issue.1, pp.5312-5330, 1996. ,
DOI : 10.1016/S0959-437X(96)90004-0
A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function, Oncogene, vol.20, issue.6, pp.659-668, 2001. ,
DOI : 10.1038/sj.onc.1204139
Regulation of Human p53 Activity and Cell Localization by Alternative Splicing, Molecular and Cellular Biology, vol.24, issue.18, pp.7987-7997, 2004. ,
DOI : 10.1128/MCB.24.18.7987-7997.2004
MOLECULAR BIOLOGY: Getting p53 Out of the Nucleus, Science, vol.292, issue.5523, pp.1851-1852, 2001. ,
DOI : 10.1126/science.1062238
Analysis of cell-cycle profiles in transfected cells using a membrane-targeted GFP, Biotechniques, vol.24, issue.352, pp.349-50, 1998. ,
Membrane-targeted green fluorescent protein reliably and uniquely marks cells through apoptotic death, Cytometry, vol.140, issue.4, pp.273-278, 2001. ,
DOI : 10.1002/1097-0320(20010401)43:4<273::AID-CYTO1059>3.0.CO;2-3
New targets for therapy in breast cancer: Farnesyltransferase inhibitors, Breast Cancer Research, vol.23, issue.6, pp.262-268, 2004. ,
DOI : 10.1158/1078-0432.CCR-03-0412
Combination therapy with the farnesyl protein transferase inhibitor SCH66336 and SCH58500 (p53 adenovirus) in preclinical cancer models, Cancer Res, vol.59, pp.5896-5901, 1999. ,
A simplified system for generating recombinant adenoviruses, Proceedings of the National Academy of Sciences, vol.71, issue.3, pp.2509-2514, 1998. ,
DOI : 10.1016/S1097-2765(00)80002-7