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Study of the impact of perilipin polymorphisms in a French population.

Abstract : BACKGROUND: Perilipins are proteins localized at the surface of the lipid droplet in adipocytes, steroid-producing cells and ruptured atherosclerotic plaques playing a role in the regulation of triglyceride deposition and mobilization. We investigated whether perilipin gene polymorphisms were associated with obesity, type 2 diabetes, and their related variables (anthropometric variables, plasma leptin, lipids, glucose and insulin concentrations) in a cross-sectional random sample of 1120 French men and women aged 35 to 65 years old, including 227 obese (BMI >or= 30 kg/m2) and 275 type 2 diabetes subjects. RESULTS: Among 7 perilipin polymorphisms tested, only 2 (rs4578621 and rs894160) of them were frequent enough to be fully investigated and we genotyped the sample using the PCR-RFLP method. No significant associations could be found between any of these polymorphisms and the studied phenotypes. CONCLUSION: The rs4578621 and rs894160 polymorphisms of the perilipin gene are not major genetic determinants of obesity and type 2 diabetes-related phenotypes in a random sample of French men and women.
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Submitted on : Tuesday, August 22, 2006 - 3:27:40 PM
Last modification on : Friday, March 27, 2020 - 1:01:55 AM
Long-term archiving on: : Tuesday, September 18, 2012 - 4:48:05 PM

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Aline Meirhaeghe, Séverine Thomas, Frédéric Ancot, Dominique Cottel, Dominique Arveiler, et al.. Study of the impact of perilipin polymorphisms in a French population.. Journal of Negative Results in BioMedicine, BioMed Central, 2006, 5, pp.10. ⟨10.1186/1477-5751-5-10⟩. ⟨inserm-00089591⟩

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