T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity, Science, vol.265, issue.5174, pp.946-949, 1994. ,
DOI : 10.1126/science.8052850
Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness., Proceedings of the National Academy of Sciences, vol.91, issue.26, pp.12862-12866, 1994. ,
DOI : 10.1073/pnas.91.26.12862
???? T cell receptor interactions with syngeneic and allogeneic ligands: Affinity measurements and crystallization, Proceedings of the National Academy of Sciences, vol.90, issue.23, pp.13838-13843, 1997. ,
DOI : 10.1073/pnas.90.23.11272
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC28394
Selection of Antigen-specific T Cells by a Single IEk Peptide Combination, Journal of Experimental Medicine, vol.355, issue.6357, pp.1441-1450, 1997. ,
DOI : 10.1038/355224a0
Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2, J Immunol, vol.157, pp.5403-5410, 1996. ,
Phenotypic Analysis of Antigen-Specific T Lymphocytes, Science, vol.336, issue.6198, pp.94-96, 1996. ,
DOI : 10.1084/jem.183.4.1367
Oligomeric MHC molecules and their homologues: state of the art, Journal of Immunological Methods, vol.268, issue.1, pp.3-7, 2002. ,
DOI : 10.1016/S0022-1759(02)00194-1
The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular staining, Journal of Immunological Methods, vol.268, issue.1, pp.9-19, 2002. ,
DOI : 10.1016/S0022-1759(02)00195-3
T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo, The Journal of Experimental Medicine, vol.150, issue.9, pp.1395-1402, 1998. ,
DOI : 10.1084/jem.186.9.1407
Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8+ T Lymphocytes in Healthy Seropositive Donors, Journal of Virology, vol.74, issue.17, pp.8140-8150, 2000. ,
DOI : 10.1128/JVI.74.17.8140-8150.2000
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors, Proceedings of the National Academy of Sciences, vol.375, issue.6532, pp.2709-2714, 2000. ,
DOI : 10.1038/375606a0
A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers, J Immunol, vol.162, pp.1827-1835, 1999. ,
Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes, The Journal of Experimental Medicine, vol.57, issue.9, pp.1641-1650, 1998. ,
DOI : 10.1126/science.274.5291.1363
HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides., Proceedings of the National Academy of Sciences, vol.89, issue.8, pp.3429-3433, 1992. ,
DOI : 10.1073/pnas.89.8.3429
Frontiers in peptide???MHC class II multimer technology, Nature Immunology, vol.3, issue.10, pp.887-889, 2002. ,
DOI : 10.1038/ni1002-887
Hindering auxiliary anchors are potent modulators of peptide binding and selection by I-Ak class II molecules, Proceedings of the National Academy of Sciences, vol.257, issue.5072, pp.11460-11465, 2000. ,
DOI : 10.1126/science.1323877
Labeling antigen-specific CD4+ T cells with class II MHC oligomers, Journal of Immunological Methods, vol.268, issue.1, pp.51-69, 2002. ,
DOI : 10.1016/S0022-1759(02)00200-4
A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response, Immunity, vol.10, issue.4, pp.485-492, 1999. ,
DOI : 10.1016/S1074-7613(00)80048-5
Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen, Immunity, vol.8, issue.6, pp.667-673, 1998. ,
DOI : 10.1016/S1074-7613(00)80571-3
Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes, Immunity, vol.8, issue.6, pp.675-682, 1998. ,
DOI : 10.1016/S1074-7613(00)80572-5
Selective Activation and Expansion of High-Affinity CD4+ T Cells in Resistant Mice upon Infection with Leishmania major, Immunity, vol.13, issue.6, pp.771-782, 2000. ,
DOI : 10.1016/S1074-7613(00)00075-3
Kinetics of T-cell Receptor Binding by Bivalent HLA-DR{middle dot}Peptide Complexes That Activate Antigen-specific Human T-cells, Journal of Biological Chemistry, vol.275, issue.1, pp.312-321, 2000. ,
DOI : 10.1074/jbc.275.1.312
HLA class II tetramers: Tools for direct analysis of antigen-specific CD4+ T cells, Arthritis & Rheumatism, vol.46, issue.1, pp.5-12, 2002. ,
DOI : 10.1002/1529-0131(200201)46:1<5::AID-ART10063>3.0.CO;2-S
MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen, Journal of Clinical Investigation, vol.104, issue.12, pp.63-70, 1999. ,
DOI : 10.1172/JCI8476
Distinct T Cell Interactions with HLA Class II Tetramers Characterize a Spectrum of TCR Affinities in the Human Antigen-Specific T Cell Response, The Journal of Immunology, vol.165, issue.12, pp.6994-6998, 2000. ,
DOI : 10.4049/jimmunol.165.12.6994
HLA Class II-Restricted CD4+ T Cell Responses Directed Against Influenza Viral Antigens Postinfluenza Vaccination, The Journal of Immunology, vol.171, issue.6, pp.3163-3169, 2003. ,
DOI : 10.4049/jimmunol.171.6.3163
Soluble, High-Affinity Dimers of T-Cell Receptors and Class II Major Histocompatibility Complexes: Biochemical Probes for Analysis and Modulation of Immune Responses, Cellular Immunology, vol.192, issue.2, pp.175-184, 1999. ,
DOI : 10.1006/cimm.1999.1441
Reliable generation and use of MHC class II:??2aFc multimers for the identification of antigen-specific CD4+ T cells, Journal of Immunological Methods, vol.271, issue.1-2, pp.137-151, 2002. ,
DOI : 10.1016/S0022-1759(02)00343-5
Use of Peptide Libraries to Map the Substrate Specificity of a Peptide-Modifying Enzyme: A 13 Residue Consensus Peptide Specifies Biotinylation in Escherichia coli, Bio/Technology, vol.74, issue.10, pp.1138-1143, 1993. ,
DOI : 10.1038/nbt1093-1138
Refolding of human class II major histocompatibility complex molecules isolated from Escherichia coli. Assembly of peptide-free heterodimers and increased refolding-yield in the presence of antigenic peptide, J Biol Chem, vol.269, pp.29571-29578, 1994. ,
Refolding and Reconstitution of Functionally Active Complexes of Human Leukocyte Antigen DR2 and Myelin Basic Protein Peptide from Recombinant and Polypeptide Chains, Journal of Biological Chemistry, vol.270, issue.2, pp.971-977, 1995. ,
DOI : 10.1074/jbc.270.2.971
Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells, European Journal of Immunology, vol.3, issue.12, pp.2237-2242, 1989. ,
DOI : 10.1002/eji.1830191209
A role for peptide in determining MHC class II structure, Nature, vol.353, issue.6340, pp.167-170, 1991. ,
DOI : 10.1038/353167a0
Cutting Edge: Detection of Antigen-Specific CD4+ T Cells by HLA-DR1 Oligomers Is Dependent on the T Cell Activation State, The Journal of Immunology, vol.166, issue.2, pp.741-745, 2001. ,
DOI : 10.4049/jimmunol.166.2.741
Human helper T-cell clones that recognize different influenza hemagglutinin determinants are restricted by different HLA-D region epitopes, Immunogenetics, vol.271, issue.2, pp.409-423, 1984. ,
DOI : 10.1007/BF00364644
Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells, Journal of Virology, vol.78, issue.13, pp.7284-7287, 2004. ,
DOI : 10.1128/JVI.78.13.7284-7287.2004
Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen MAGE-3, Blood, vol.101, issue.3, pp.1038-1044, 2003. ,
DOI : 10.1182/blood-2002-03-0933
Longitudinal mapping of protective CD4+ T cell responses against HCV: analysis of fluctuating dominant and subdominant HLA-DR11 restricted epitopes, Journal of Viral Hepatitis, vol.170, issue.4, pp.324-331, 2004. ,
DOI : 10.1084/jem.188.10.1785
Use of synthetic peptides to establish anti-human acetylcholine receptor CD4+ cell lines from myasthenia gravis patients, J Immunol, vol.144, pp.1711-1720, 1990. ,