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Comparing strategies for association mapping in samples with related individuals.

Abstract : In this paper, different strategies to test for association in samples with related individuals designed for linkage studies are compared. Because no independent controls are available, a family-based association test and case-control tests corrected for the presence of related individuals in which unaffected relatives are used as controls were tested. When unrelated controls are available, additional strategies including selection of a single case per family considering either all families or a subset of linked families, are also considered. Analyses are performed on the simulated dataset, blind to the answers. The case-control test corrected for the presence of related individuals is the most powerful strategy to detect three loci associated with the disease under study. Using a correction factor for the case-control test performed conditional on the marker information rather than unconditional does not impact the power significantly.
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https://www.hal.inserm.fr/inserm-00089271
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Submitted on : Wednesday, August 16, 2006 - 4:35:24 PM
Last modification on : Wednesday, September 16, 2020 - 4:57:34 PM
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Catherine Bourgain. Comparing strategies for association mapping in samples with related individuals.. BMC Genetics, BioMed Central, 2005, 6 Suppl 1, pp.S98. ⟨10.1186/1471-2156-6-S1-S98⟩. ⟨inserm-00089271⟩

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