No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome. - Archive ouverte HAL Access content directly
Journal Articles Arthritis Research and Therapy Year : 2006

No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome.

(1) , (1) , (1) , (1) , (2) , (3) , (4) , (4) , (5) , (1) , (1)
1
2
3
4
5

Abstract

Polyclonal B cell activation might be related to pathogenic over-expression of B-cell-activating factor (BAFF) in primary Sj?n's syndrome (pSS) and other autoimmune diseases. We therefore investigated whether BAFF over-expression in pSS could be a primary, genetically determined event that leads to the disease. The complete BAFF gene was sequenced in Caucasian pSS patients and control individuals. The only single nucleotide polymorphism frequently observed, namely -871 T/C in the promoter region, was then genotyped in 162 French patients with pSS and 90 French control individuals. No significant differences in allele (T allele frequency: 49.7% in patients with pSS versus 50% in controls; P = 0.94) and genotype frequencies of BAFF polymorphism were detected between pSS patients and control individuals. BAFF gene polymorphism was not associated with a specific pattern of antibody secretion either. T allele carriers had significantly increased BAFF protein serum levels (mean values of 8.6 and 5.7 ng/ml in patients with TT and TC genotypes, respectively, versus 3.3 ng/ml in patients with CC genotype; P = 0.01), although no correlation was observed between BAFF polymorphism and mRNA level. In conclusion, BAFF gene polymorphism is neither involved in genetic predisposition to pSS nor associated with a specific pattern of antibody production.
Fichier principal
Vignette du fichier
ar1884.pdf (154.24 Ko) Télécharger le fichier
Loading...

Dates and versions

inserm-00089238 , version 1 (16-08-2006)

Identifiers

Cite

Jacques-Eric Gottenberg, Jérémie Sellam, Marc Ittah, Frédéric Lavie, Alexis Proust, et al.. No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome.. Arthritis Research and Therapy, 2006, 8, pp.R30. ⟨10.1186/ar1884⟩. ⟨inserm-00089238⟩

Collections

INSERM
392 View
414 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More