Skip to Main content Skip to Navigation
Journal articles

VNTR polymorphism of the insulin gene and childhood overweight in a general population.

Abstract : OBJECTIVE: The VNTR polymorphism 5' of the insulin gene has been related to obesity in a previous study on children with early onset of severe obesity. Our purpose was to analyze the association between this polymorphism and adiposity variability in an unselected population of children and adolescents in northern France. RESEARCH METHODS AND PROCEDURES: In 293 nuclear families from the Fleurbaix Laventie Ville Sant?tudy, we genotyped the INS VNTR polymorphism in 431 children and adolescents (8 to 18 years of age) and their parents. Overweight was defined according to the international definition in both children and adults. A transmission disequilibrium test in families with an overweight offspring was performed. The prevalence of overweight was compared according to genotype. The effect of the genotype on BMI and waist circumference was tested with a linear regression model, adjusting for age, gender, and Tanner stage. RESULTS: There was an undertransmission of class III alleles from heterozygous parents to their overweight offspring (p < 0.002). Overweight was associated with class I alleles in children and adolescents (12% I/I, I/III vs. 3% III/III; p < 0.08). Those with a class III/III genotype had a 1 kg/m(2) lower mean BMI (p = 0.04) and 3 cm lower waist circumference (p = 0.02) than those bearing one or two class I alleles. No association of adiposity or obesity with class I alleles was found in parents. DISCUSSION: INS VNTR polymorphism seems to contribute to differences in adiposity level in the general population of children and adolescents.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00086410
Contributor : Nadine Kaniewski <>
Submitted on : Tuesday, July 18, 2006 - 4:04:52 PM
Last modification on : Wednesday, September 16, 2020 - 4:57:34 PM

Identifiers

  • HAL Id : inserm-00086410, version 1
  • PUBMED : 15044667

Collections

Citation

Barbara Heude, Séverine Dubois, Marie-Aline Charles, Marianne Deweirder, Christian Dina, et al.. VNTR polymorphism of the insulin gene and childhood overweight in a general population.. Obesity Research, The North American Association for the Study of, 2004, 12, pp.499-504. ⟨inserm-00086410⟩

Share

Metrics

Record views

177