Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy.

Jacqueline Clavel; Stéphanie Bellec; Sandra Rebouissou; Florence Menegaux; Jean Feunteun; Catherine Bonaïti-Pellié; André Baruchel; Kamila Kebaili; Anne Lambilliotte; Guy Leverger; Danièle Sommelet; Brigitte Lescoeur; Philippe Beaune; Denis Hémon; Marie-Anne Loriot

Journal articles

Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy.

Jacqueline Clavel ¹ Stéphanie Bellec ¹ Sandra Rebouissou ² Florence Menegaux ¹ Jean Feunteun ³ Catherine Bonaïti-Pellié ⁴ André Baruchel ⁵ Kamila Kebaili ⁶ Anne Lambilliotte ⁷ Guy Leverger ⁸ Danièle Sommelet ⁹ Brigitte Lescoeur ¹⁰ Philippe Beaune ² Denis Hémon ¹ Marie-Anne Loriot ²

1 Recherches épidémiologiques et statistiques sur l'environnement et la santé.

2 U490 - Toxicologie Moleculaire

3 GO - UMR 8125 - Génétique oncologique

4 Inserm U535 - Génétique épidémiologique et structures des populations humaines

5 Service d'hématologie pédiatrique

6 Service d'hématologie : Immuno-Hématologie pédiatrique et transplantation de moelle osseuse

7 Service d'hématologie pédiatrique-oncologie

8 Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau]

9 Service d'Hématologie Pédiatrique [CHRU Nancy]

10 Service d'hématologie et immunologie pédiatrique

Abstract : Metabolic polymorphisms may influence the risk of childhood leukaemia related to maternal tobacco, coffee or alcohol consumption. The data were extracted from a case-control study including 280 cases of acute leukaemia and 288 controls. Blood sampling was obtained for a representative subset of 219 cases and 105 controls. Gene-environment interactions were estimated using both case-control and case-only analyses. The polymorphisms of CYP1A1, GSTM1, GSTP1, GSTT1 and NQO1 were not associated with the risk of leukaemia. The slow EPHX1 allele was negatively associated with childhood leukaemia while an inverse non-significant association was observed with the fast EPHX1 allele. Maternal smoking during pregnancy was not related to leukaemia, but an interaction was observed in the case-only analysis with CYP1A1*2A variant allele (odds ratio (OR) 2.2 [1.0-4.9]) and with GSTM1 deletion (OR 2.3 [1.2-4.4]). Conversely, coffee drinking interacted negatively with NQO1 polymorphism in the case-only analysis (OR 0.6 [0.3-1.2] and 0.4 [0.1-1.0] for light and heavy coffee consumptions, respectively). This study suggests that maternal smoking may be a risk factor for leukaemia in children who carry CYP1A1 or GSTM1 genotypes, which might increase reactive metabolites of polycyclic aromatic hydrocarbons.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Santé publique et épidémiologie

Life Sciences [q-bio] / Cancer

Life Sciences [q-bio] / Human health and pathology / Gynecology and obstetrics

Complete list of metadatas

https://www.hal.inserm.fr/inserm-00085373
Contributor : Nadine Kaniewski <>
Submitted on : Tuesday, July 25, 2006 - 11:49:46 AM
Last modification on : Wednesday, September 16, 2020 - 4:57:34 PM

Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy.

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Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy.

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