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Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli.

Abstract : We tested the hypotheses that catalase activity is modified by CAT single nucleotide polymorphisms (SNPs) (-262;-844), and by their interactions with oxidant exposures (coal dusts, smoking), lymphotoxin alpha (LTA, NcoI) and tumor necrosis factor (TNF, -308) in 196 miners. Erythrocyte catalase, superoxide dismutase, and glutathione peroxidase activities were measured. The CAT -262 SNP was related to lower catalase activity (104, 87 and 72 k/g hemoglobin for CC, CT and TT, respectively, p < 0.0001). Regardless of CAT SNPs, the LTA NcoI but not the TNF-308 SNP was associated with catalase activity (p = 0.04 and p = 0.8). CAT -262 T carriers were less frequent in highly exposed miners (OR = 0.39 [0.20-0.78], p = 0.007). In CAT -262 T carriers only, catalase activity decreased with high dust exposure (p = 0.01). Haplotype analyses (combined CAT SNPs) confirm these results. Results show that CAT -262 and LTA NcoI SNPs, and interaction with coal dust exposure, influenced catalase activity.
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https://www.hal.inserm.fr/inserm-00085360
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Submitted on : Monday, January 29, 2007 - 5:57:31 PM
Last modification on : Friday, February 22, 2019 - 11:44:17 AM
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Rachel Nadif, Margaret Mintz, Anne Jedlicka, Jean-Pierre Bertrand, Steven Kleeberger, et al.. Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli.. Free Radic Res, 2005, 39, pp.1345-50. ⟨10.1080/10715760500306711⟩. ⟨inserm-00085360⟩

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