R. Watson, M. Kanzaki, and J. Pessin, Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes, Endocrine Reviews, vol.25, issue.2, pp.177-204, 2004.
DOI : 10.1210/er.2003-0011

J. Liu, A. Kimura, and C. Baumann, APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes, Molecular and Cellular Biology, vol.22, issue.11, pp.3599-3609
DOI : 10.1128/MCB.22.11.3599-3609.2002

M. Yokouchi, R. Suzuki, M. Masuhara, S. Komiya, A. Inoue et al., Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation, Oncogene, vol.15, issue.1, pp.7-15, 1997.
DOI : 10.1038/sj.onc.1201163

S. Moodie, J. Alleman-sposeto, and T. Gustafson, Identification of the APS Protein as a Novel Insulin Receptor Substrate, Journal of Biological Chemistry, vol.274, issue.16, pp.11186-11193, 1999.
DOI : 10.1074/jbc.274.16.11186

Z. Ahmed, B. Smith, and T. Pillay, The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor, FEBS Letters, vol.95, issue.1, pp.31-34, 2000.
DOI : 10.1016/S0014-5793(00)01621-5

J. Hu, J. Liu, R. Ghirlando, A. Saltiel, and S. Hubbard, Structural Basis for Recruitment of the Adaptor Protein APS to the Activated Insulin Receptor, Molecular Cell, vol.12, issue.6, pp.1379-1389, 2003.
DOI : 10.1016/S1097-2765(03)00487-8

Z. Ahmed, B. Smith, K. Kotani, P. Wilden, and T. Pillay, APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase, Biochemical Journal, vol.341, issue.3, pp.665-668, 1999.
DOI : 10.1042/bj3410665

M. Ahn, K. Katsanakis, F. Bheda, and T. Pillay, Primary and Essential Role of the Adaptor Protein APS for Recruitment of Both c-Cbl and Its Associated Protein CAP in Insulin Signaling, Journal of Biological Chemistry, vol.279, issue.20, pp.21526-21532, 2004.
DOI : 10.1074/jbc.M307740200

A. Minami, M. Iseki, K. Kishi, M. Wang, M. Ogura et al., Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice, Diabetes, vol.52, issue.11, pp.2657-2665, 2003.
DOI : 10.2337/diabetes.52.11.2657

M. Li, D. Ren, M. Iseki, S. Takaki, and L. Rui, Differential Role of SH2-B and APS in Regulating Energy and Glucose Homeostasis, Endocrinology, vol.147, issue.5, pp.2163-2170, 2006.
DOI : 10.1210/en.2005-1313

R. Barres, T. Gonzalez, Y. Marchand-brustel, and J. Tanti, The interaction between the adaptor protein APS and Enigma is involved in actin organisation, Experimental Cell Research, vol.308, issue.2, pp.334-344, 2005.
DOI : 10.1016/j.yexcr.2005.05.008
URL : https://hal.archives-ouvertes.fr/inserm-00081029

T. Khurana, B. Khurana, and A. Noegel, LIM proteins: association with the actin cytoskeleton, Protoplasma, vol.219, issue.1-2, pp.1-12, 2002.
DOI : 10.1007/s007090200000

P. Guy, D. Kenny, and G. Gill, The PDZ Domain of the LIM Protein Enigma Binds to beta -Tropomyosin, Molecular Biology of the Cell, vol.10, issue.6, pp.1973-1984, 1999.
DOI : 10.1091/mbc.10.6.1973

K. Durick, R. Wu, G. Gill, and S. Taylor, Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain, J Biol Chem, vol.271, pp.12691-12694, 1996.

R. Wu and G. Gill, LIM domain recognition of a tyrosine-containing tight turn, J Biol Chem, vol.269, pp.25085-25090, 1994.

R. Wu, K. Durick, Z. Songyang, L. Cantley, S. Taylor et al., Specificity of LIM Domain Interactions with Receptor Tyrosine Kinases, Journal of Biological Chemistry, vol.271, issue.27, pp.15934-15941, 1996.
DOI : 10.1074/jbc.271.27.15934

M. Kanzaki and J. Pessin, Insulin-stimulated GLUT4 Translocation in Adipocytes Is Dependent upon Cortical Actin Remodeling, Journal of Biological Chemistry, vol.276, issue.45, pp.42436-42444, 2001.
DOI : 10.1074/jbc.M108297200

M. Mari, P. Monzo, V. Kaddai, F. Keslair, T. Gonzalez et al., The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes, Journal of Cell Science, vol.119, issue.7, pp.1297-1306, 2006.
DOI : 10.1242/jcs.02850

S. Chiang, C. Baumann, M. Kanzaki, D. Thurmond, R. Watson et al., Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10, Nature, vol.20, issue.6831, pp.944-948, 2001.
DOI : 10.1038/35073608

S. Arber, J. Hunter, J. Ross, J. Hongo, M. Sansig et al., MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure, Cell, vol.88, issue.3, pp.393-403, 1997.
DOI : 10.1016/S0092-8674(00)81878-4

K. Bauer, M. Kratzer, M. Otte, K. De-quintana, J. Hagmann et al., Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells, Blood, vol.96, pp.4236-4245, 2000.

I. Coghill, S. Brown, D. Cottle, M. Mcgrath, P. Robinson et al., FHL3 Is an Actin-binding Protein That Regulates ??-Actinin-mediated Actin Bundling: FHL3 LOCALIZES TO ACTIN STRESS FIBERS AND ENHANCES CELL SPREADING AND STRESS FIBER DISASSEMBLY, Journal of Biological Chemistry, vol.278, issue.26, pp.24139-24152, 2003.
DOI : 10.1074/jbc.M213259200

I. Dawid, J. Breen, and R. Toyama, LIM domains: multiple roles as adapters and functional modifiers in protein interactions, Trends in Genetics, vol.14, issue.4, pp.156-162, 1998.
DOI : 10.1016/S0168-9525(98)01424-3

A. Saltiel and J. Pessin, Insulin signaling pathways in time and space, Trends in Cell Biology, vol.12, issue.2, pp.65-71, 2002.
DOI : 10.1016/S0962-8924(01)02207-3

K. Durick, G. Gill, and S. Taylor, Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2, Molecular and Cellular Biology, vol.18, issue.4, pp.2298-2308, 1998.
DOI : 10.1128/MCB.18.4.2298

T. Vallenius, B. Scharm, A. Vesikansa, K. Luukko, R. Schafer et al., The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of ??-actinin with F-actin, Experimental Cell Research, vol.293, issue.1, pp.117-128, 2004.
DOI : 10.1016/j.yexcr.2003.09.004

T. Tsakiridis, M. Vranic, and A. Klip, of the actin network inhibits insulindependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane, J Biol Chem, vol.269, pp.29934-29942, 1994.

W. Omata, H. Shibata, L. Li, K. Takata, and I. Kojima, Actin filaments play a critical role in insulin-induced exocytotic recruitment but not in endocytosis of GLUT4 in isolated rat adipocytes, Biochem J 346 Pt, vol.2, pp.321-328, 2000.

T. Tsakiridis, P. Tong, B. Matthews, E. Tsiani, P. Bilan et al., Role of the actin cytoskeleton in insulin action, Microscopy Research and Technique, vol.267, issue.2, pp.79-92, 1999.
DOI : 10.1002/(SICI)1097-0029(19991015)47:2<79::AID-JEMT1>3.0.CO;2-S

R. Watson, M. Furukawa, S. Chiang, D. Boeglin, M. Kanzaki et al., The Exocytotic Trafficking of TC10 Occurs through both Classical and Nonclassical Secretory Transport Pathways in 3T3L1 Adipocytes, Molecular and Cellular Biology, vol.23, issue.3, pp.961-974, 2003.
DOI : 10.1128/MCB.23.3.961-974.2003

M. Kanzaki, R. Watson, A. Khan, and J. Pessin, Insulin Stimulates Actin Comet Tails on Intracellular GLUT4-containing Compartments in Differentiated 3T3L1 Adipocytes, Journal of Biological Chemistry, vol.276, issue.52, pp.49331-49336, 2001.
DOI : 10.1074/jbc.M109657200

M. Iseki, C. Kubo, S. Kwon, A. Yamaguchi, Y. Kataoka et al., Increased Numbers of B-1 Cells and Enhanced Responses against TI-2 Antigen in Mice Lacking APS, an Adaptor Molecule Containing PH and SH2 Domains, Molecular and Cellular Biology, vol.24, issue.6, pp.2243-2250, 2004.
DOI : 10.1128/MCB.24.6.2243-2250.2004

C. Kubo-akashi, M. Iseki, S. Kwon, H. Takizawa, K. Takatsu et al., Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly, Biochemical and Biophysical Research Communications, vol.315, issue.2, pp.356-362, 2004.
DOI : 10.1016/j.bbrc.2004.01.060

M. Cormont, M. Bortoluzzi, N. Gautier, M. M. Van-obberghen, E. et al., Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes., Molecular and Cellular Biology, vol.16, issue.12, pp.6879-6886, 1996.
DOI : 10.1128/MCB.16.12.6879

S. Dobson, C. Livingstone, G. Gould, and J. Tavare, Dynamics of insulin-stimulated translocation of GLUT4 in single living cells visualised using green fluorescent protein, FEBS Letters, vol.5, issue.2-3, pp.179-184, 1996.
DOI : 10.1016/0014-5793(96)00879-4