A. Agrawal and D. G. Schatz, RAG1 and RAG2 Form a Stable Postcleavage Synaptic Complex with DNA Containing Signal Ends in V(D)J Recombination, Cell, vol.89, issue.1, pp.43-53, 1997.
DOI : 10.1016/S0092-8674(00)80181-6

S. Akira, K. Okazaki, and H. Sakano, Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining, Science, vol.238, issue.4830, pp.1134-1138, 1987.
DOI : 10.1126/science.3120312

F. W. Alt and D. Baltimore, Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions., Proc. Natl. Acad. Sci. USA 79, pp.4118-4122, 1982.
DOI : 10.1073/pnas.79.13.4118

L. Bentolila, G. Wu, F. Nourrit, M. Fanton-d-'andon, F. Rougeon et al., Constitutive expression of terminal deoxynucleotidyl transferase in transgenic mice is sufficient for N region diversity to occur at any Ig locus throughout B cell differentiation, J. Immunol, vol.158, pp.715-723, 1997.

M. Bogue, S. Candeías, C. Benoist, and D. Mathis, A special repertoire of alpha:beta T cells in neonatal mice, EMBO J, vol.10, pp.3647-3654, 1991.

S. Candeías, C. Waltzinger, C. Benoist, and D. Mathis, The V beta 17+ T cell repertoire: skewed J beta usage after thymic selection; dissimilar CDR3s in CD4+ versus CD8+ cells, Journal of Experimental Medicine, vol.174, issue.5, pp.989-1000, 1991.
DOI : 10.1084/jem.174.5.989

S. Candeías, K. Muegge, and S. K. Durum, Junctional diversity in signal joints from T cell receptor beta and delta loci via terminal deoxynucleotidyl transferase and exonucleolytic activity, Journal of Experimental Medicine, vol.184, issue.5, pp.1919-1926, 1996.
DOI : 10.1084/jem.184.5.1919

Y. H. Chien, M. Iwashima, D. A. Wettstein, K. B. Kaplan, J. F. Elliott et al., T-cell receptor delta gene rearrangements in early thymocytes, Nature, vol.330, pp.722-727, 1987.

Y. Dai, B. Kysela, L. A. Hanakahi, K. Manolis, E. Riballo et al., Nonhomologous end joining and V(D)J recombination require an additional factor, Proc. Natl. Acad. Sci. USA, pp.2462-2467, 2003.
DOI : 10.1146/annurev.genet.31.1.635

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151363

J. P. De-villartay, R. D. Hockett, D. Coran, S. J. Korsmeyer, and D. I. Cohen, Deletion of the human T-cell receptor ??-gene by a site-specific recombination, Nature, vol.335, issue.6186, pp.170-174, 1988.
DOI : 10.1038/335170a0

M. Gallagher, P. Obeid, P. N. Marche, and E. Jouvin-marche, Both TCR?? and TCR?? Chain Diversity Are Regulated During Thymic Ontogeny, The Journal of Immunology, vol.167, issue.3, pp.1447-1453, 2001.
DOI : 10.4049/jimmunol.167.3.1447

G. H. Gauss and M. R. Lieber, Mechanistic constraints on diversity in human V(D)J recombination., Molecular and Cellular Biology, vol.16, issue.1, pp.258-269, 1996.
DOI : 10.1128/MCB.16.1.258

S. Gilfillan, A. Dierich, M. Lemeur, C. Benoist, and D. Mathis, Mice lacking TdT: mature animals with an immature lymphocyte repertoire, Science, vol.261, issue.5125, pp.1175-1178, 1993.
DOI : 10.1126/science.8356452

M. D. Hazenberg, S. A. Otto, C. Stuart, J. W. Verschuren, M. C. Borleffs et al., Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection, Nat. Med, vol.6, pp.1036-1042, 2000.

M. D. Hazenberg, M. C. Verschuren, D. Hamann, F. Miedema, and J. J. Van-dongen, T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation, Journal of Molecular Medicine, vol.79, issue.11, pp.631-640, 2001.
DOI : 10.1007/s001090100271

J. E. Hesse, M. R. Lieber, K. Mizuuchi, and M. Gellert, V(D)J recombination: a functional definition of the joining signals., Genes & Development, vol.3, issue.7, pp.1053-1061, 1989.
DOI : 10.1101/gad.3.7.1053

E. P. Hochberg, A. C. Chillemi, C. J. Wu, D. Neuberg, C. Canning et al., Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults, Blood, vol.98, issue.4, pp.1116-1121, 2001.
DOI : 10.1182/blood.V98.4.1116

T. Iwasato and H. Yamagishi, Novel excision products of T cell receptor ?? gene rearrangements and developmental stage specificity implied by the frequency of nucleotide insertions at signal joints, European Journal of Immunology, vol.5, issue.1, pp.101-106, 1992.
DOI : 10.1002/eji.1830220116

E. Jouvin-marche, C. Aude-garcia, S. Candeías, E. Borel, S. Hachemi-rachedi et al., Differential chronology of TCRADV2 gene use by ?? and ?? chains of the mouse TCR, European Journal of Immunology, vol.39, issue.3, pp.818-827, 1998.
DOI : 10.1002/(SICI)1521-4141(199803)28:03<818::AID-IMMU818>3.0.CO;2-0

D. Jung and F. W. Alt, Unraveling V(D)J Recombination, Cell, vol.116, issue.2, pp.299-311, 2004.
DOI : 10.1016/S0092-8674(04)00039-X

URL : http://doi.org/10.1016/s0092-8674(04)00039-x

Y. Kanari, R. Nakagawa, H. Arakawa, and H. Yamagishi, Variable gene segment-specific N-insertions at the signal joint of T-cell receptor V??-D?? recombinations, Immunology Letters, vol.61, issue.2-3, pp.151-155, 1998.
DOI : 10.1016/S0165-2478(98)00012-1

M. S. Krangel, C. Hernandez-munain, P. Lauzurica, M. Mcmurry, J. L. Roberts et al., Developmental regulation of V(D)J recombination at the TCR a/5 locus, Immunological Reviews, vol.14, issue.1, pp.131-147, 1998.
DOI : 10.1016/0092-8674(95)90008-X

S. Lewis, A. Gifford, and D. Baltimore, DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes, Science, vol.228, issue.4700, pp.677-685, 1985.
DOI : 10.1126/science.3158075

Y. Li, K. Hayakawa, and R. Hardy, The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver, Journal of Experimental Medicine, vol.178, issue.3, pp.951-960, 1993.
DOI : 10.1084/jem.178.3.951

Z. Li, D. I. Dordai, J. Lee, and S. Desiderio, A Conserved Degradation Signal Regulates RAG-2 Accumulation during Cell Division and Links V(D)J Recombination to the Cell Cycle, Immunity, vol.5, issue.6, pp.575-589, 1996.
DOI : 10.1016/S1074-7613(00)80272-1

Y. Ma, U. Pannicke, K. Schwarz, and M. R. Lieber, Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination, Cell, vol.108, issue.6, pp.781-794, 2002.
DOI : 10.1016/S0092-8674(02)00671-2

K. N. Mahajan, L. Gangi-peterson, D. H. Sorscher, J. Wang, K. N. Gathy et al., Association of terminal deoxynucleotidyl transferase with Ku, Proc. Natl. Acad. Sci. USA 96, pp.13926-13931, 1999.
DOI : 10.1093/emboj/17.6.1819

S. J. Mancini, S. M. Candeias, D. Santo, J. P. Ferrier, P. Marche et al., TCRA Gene Rearrangement in Immature Thymocytes in Absence of CD3, Pre-TCR, and TCR Signaling, The Journal of Immunology, vol.167, issue.8, pp.4485-4493, 2001.
DOI : 10.4049/jimmunol.167.8.4485

J. F. Mcblane, D. C. Van-gent, D. A. Ramsden, C. Romeo, C. A. Cuomo et al., Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps, Cell, vol.83, issue.3, pp.387-395, 1995.
DOI : 10.1016/0092-8674(95)90116-7

D. Moshous, I. Callebaut, R. De-chasseval, B. Corneo, M. Cavazzana-calvo et al., Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency, Cell, vol.105, issue.2, pp.177-186, 2001.
DOI : 10.1016/S0092-8674(01)00309-9

B. Nadel, S. Tehranchi, and A. J. Feeney, Coding end processing is similar throughout ontogeny, J. Immunol, vol.154, pp.6430-6436, 1995.

E. J. Perkins, A. Nair, D. O. Cowley, T. Van-dyke, Y. Chang et al., Sensing of intermediates in V(D)J recombination by ATM, Genes & Development, vol.16, issue.2, pp.159-164, 2002.
DOI : 10.1101/gad.956902

J. Pido-lopez, N. Imami, D. Andrew, and R. Aspinall, Molecular quantitation of thymic output in mice and the effect of IL-7, European Journal of Immunology, vol.32, issue.10, pp.2827-2836, 2002.
DOI : 10.1002/1521-4141(2002010)32:10<2827::AID-IMMU2827>3.0.CO;2-X

M. M. Purugganan, S. Shah, J. F. Kearney, and D. B. Roth, Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase, Nucleic Acids Research, vol.29, issue.7, pp.1638-1646, 2001.
DOI : 10.1093/nar/29.7.1638

S. Rooney, J. Sekiguchi, C. Zhu, H. L. Cheng, J. Manis et al., Leaky Scid Phenotype Associated with Defective V(D)J Coding End Processing in Artemis-Deficient Mice, Molecular Cell, vol.10, issue.6, pp.1379-1390, 2002.
DOI : 10.1016/S1097-2765(02)00755-4

S. Rooney, J. Chaudhuri, and F. W. Alt, The role of the non-homologous end-joining pathway in lymphocyte development, Immunological Reviews, vol.14, issue.1, pp.115-131, 2004.
DOI : 10.1016/S0960-9822(01)00048-3

D. B. Roth, C. Zhu, and M. Gellert, Characterization of broken DNA molecules associated with V(D)J recombination., Proc. Natl. Acad. Sci. USA 90, pp.10788-10792, 1993.
DOI : 10.1073/pnas.90.22.10788

M. Schlissel, A. Constantinescu, T. Morrow, M. Baxter, and A. Peng, Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated., Genes & Development, vol.7, issue.12b, pp.2520-2532, 1993.
DOI : 10.1101/gad.7.12b.2520

S. O. Schonland, J. K. Zimmer, C. M. Lopez-benitez, T. Widmann, K. D. Ramin et al., Homeostatic control of T-cell generation in neonates, Blood, vol.102, issue.4, pp.1428-1434, 2003.
DOI : 10.1182/blood-2002-11-3591

E. Selsing, J. Voss, and U. Storb, Immunoglobulin gene ???remnant??? DNA - implications for antibody gene recombination, Nucleic Acids Research, vol.12, issue.10, pp.4229-4246, 1984.
DOI : 10.1093/nar/12.10.4229

T. Shimizu and H. Yamagishi, Biased reading frames of pre-existing DH?JH coding joints and preferential nucleotide insertions at VH?DJH signal joints of excision products of immunoglobulin heavy chain gene rearrangements, EMBO J, vol.11, pp.4869-4875, 1992.

M. Steinmetz, W. Altenburger, and H. G. Zachau, A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments, Nucleic Acids Research, vol.8, issue.8, pp.1709-1720, 1980.
DOI : 10.1093/nar/8.8.1709

S. R. Talukder, D. D. Dudley, F. W. Alt, Y. Takahama, and Y. Akamatsu, Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice, Nucleic Acids Research, vol.32, issue.15, pp.4539-4549, 2004.
DOI : 10.1093/nar/gkh778

T. H. Thai, M. M. Purugganan, D. B. Roth, and J. F. Kearney, Distinct and opposite diversifying activities of terminal transferase splice variants, Nature Immunology, vol.3, pp.457-462, 2002.
DOI : 10.1038/ni788

S. Tonegawa, Somatic generation of antibody diversity, Nature, vol.26, issue.5909, pp.575-581, 1983.
DOI : 10.1038/302575a0