Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue FEBS Letters Année : 2006

Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5.

Résumé

Toll-like receptors (TLR) detect pathogen-associated molecular patterns (PAMP) and play a crucial role in triggering immunity. Due to their large surfaces in direct contact with the environment, mucosal tissues are the major sites of PAMP-TLR signalling. How innate and adaptive immunity are triggered through flagellin-TLR5 interaction is the main focus of the review. In view of recent reports on genetic polymorphism, we will summarize the impact of TLR5 on the susceptibility to mucosal infections and on various immuno-pathologies. Finally, the contribution of TLRs in the induction and maintenance of mucosal homeostasis and commensal discrimination is discussed.
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Dates et versions

inserm-00071278 , version 1 (09-10-2007)

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Martin Rumbo, Clément Nempont, Jean-Pierre Kraehenbuhl, Jean-Claude Sirard. Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5.. FEBS Letters, 2006, 580 (12), pp.2976-84. ⟨10.1016/j.febslet.2006.04.036⟩. ⟨inserm-00071278⟩
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