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The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses.: The HERV family MSRV retrovirus activates innate immunity

Abstract : Multiple sclerosis-associated retroviral element (MSRV) is a retroviral element, the sequence of which served to define the W family of human endogenous retroviruses. MSRV viral particles display proinflammatory activities both in vitro in human mononuclear cell cultures and in vivo in a humanized SCID mice model. To understand the molecular basis of such properties, we have investigated the inflammatory potential of the surface unit of the MSRV envelope protein (ENV-SU), the fraction that is poised to naturally interact with host cells. We report in this study that MSRV ENV-SU induces, in a specific manner, human monocytes to produce major proinflammatory cytokines through engagement of CD14 and TLR4, which are pattern recognition receptors of primary importance in innate immunity. ENV-SU could also trigger a maturation process in human dendritic cells. Finally, ENV-SU endowed dendritic cells with the capacity to support a Th1-like type of Th cell differentiation. The data are discussed in the context of immune responses and chronic proinflammatory disorders.
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https://www.hal.inserm.fr/inserm-00000108
Contributor : Patrice Marche <>
Submitted on : Tuesday, October 28, 2008 - 10:57:22 AM
Last modification on : Friday, June 5, 2020 - 11:18:01 PM
Long-term archiving on: : Friday, November 25, 2016 - 10:34:37 AM

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  • HAL Id : inserm-00000108, version 1
  • PUBMED : 16751411

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Citation

Alexandre Rolland, Evelyne Jouvin-Marche, Christophe Viret, Mathias Faure, Hervé Perron, et al.. The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses.: The HERV family MSRV retrovirus activates innate immunity. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2006, 176 (12), pp.7636-44. ⟨inserm-00000108⟩

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