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Expression mechanisms of long-term potentiation in the hippocampus.

Abstract : We have taken a number of different experimental approaches to address whether long-term potentiation (LTP) in hippocampal CA1 pyramidal cells is due primarily to presynaptic or postsynaptic modifications. Examination of miniature EPSCs or EPSCs evoked using minimal stimulation indicate that quantal size increasing during LTP. The conversion of silent to functional synapses may contribute to the LTP-induced changes in mEPSC frequency and failure rate that previously have been attributed to an increase in the probability if transmitter release.
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https://www.hal.inserm.fr/inserm-00000086
Contributor : Stéphane Oliet <>
Submitted on : Wednesday, March 29, 2006 - 12:36:13 PM
Last modification on : Tuesday, November 5, 2019 - 10:00:07 AM

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  • HAL Id : inserm-00000086, version 1
  • PUBMED : 9089495

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John Isaac, Stéphane Oliet, Gregory Hjelmstad, Roger Nicoll, Robert Malenka. Expression mechanisms of long-term potentiation in the hippocampus.. Journal of Physiology - Paris, Elsevier, 1996, 90, pp.299-303. ⟨inserm-00000086⟩

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